Old diabetes pill may ease MS nerve pain – early trial begins

NCT ID NCT07221799

Not yet recruiting Symptom relief Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests whether an extended-release form of glibenclamide (glyburide), a diabetes drug, can safely reduce nerve pain in people with multiple sclerosis. Ten adults with MS and moderate-to-severe nerve pain will receive either the drug or a placebo. The main goal is to check safety and how the drug behaves in the body, not yet to prove it works for pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: glibenclamide (glyburide) oral extended release pill
What this could lead to: If it works, this could point toward a new way to manage nerve pain in multiple sclerosis without strong opioids.
What could go wrong: This is a very early Phase 1 safety study with only 10 people. It is not designed to prove the drug works for pain, and glibenclamide can lower blood sugar, which may cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS NEUROPATHIC PAIN

Contacts and locations

Locations

University of Maryland School of Medicine

Baltimore, Maryland, 21201, United States

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Other studies related to the condition(s) this trial covers.