MULTIPLE SCLEROSIS

This study tested whether a skin patch could deliver the drug ozanimod as well as the standard oral capsule. Ozanimod is used to treat multiple sclerosis and ulcerative colitis. Researchers compared how the body absorbed the drug from three different patch formulas versus a swall…

This trial tested whether a combination of two existing, safe drugs—metformin (for diabetes) and clemastine (an antihistamine)—could help repair the protective coating around nerves in people with relapsing multiple sclerosis (MS). The goal was to see if this repair process, call…

This study tested whether a personalized approach to walking therapy works better than standard therapy for people with spinal cord injuries or multiple sclerosis. Researchers used 3D motion capture to analyze each person's specific walking problems and then designed a six-week t…

This study looked at how well a drug called cladribine tablets worked for people with relapsing multiple sclerosis (MS) when their previous oral or infusion treatments were not controlling their disease well enough. It followed 291 patients in a real-world setting for two years t…

This study aimed to understand and compare the experiences of people with Multiple Sclerosis (MS) who were starting one of two different injectable treatments. It focused on side effects at the injection site, like pain or redness, and how satisfied patients were with the process…

This study tested whether a daily oral liquid called CNM-Au8 could improve the energy levels of brain cells in people with multiple sclerosis (MS). Thirty-three participants with different types of MS took the treatment for 12 weeks. Researchers used a special brain scan to measu…

This study tested whether personalized advice from a dietitian helps people with multiple sclerosis (MS) get enough calcium from their diet better than just receiving a standard information sheet. It involved 182 adults with MS who could walk and had never had specific calcium ad…

This study compared a monthly self-injected medication called ofatumumab against standard first-line MS therapies in people newly diagnosed with relapsing multiple sclerosis. The goal was to see which treatment was better at keeping the disease quiet—preventing relapses, stopping…

This study tested whether a patient's own banked stem cells could improve quality of life for people with multiple sclerosis (MS). Twenty-four participants received either six infusions of their stem cells or a placebo over a year, while continuing their regular MS medications. T…

This study followed over 1,000 people with multiple sclerosis (MS) who had already been taking ocrelizumab in earlier Roche-sponsored trials. The goal was to gather more information on the long-term effectiveness and safety of the drug. Participants continued receiving ocrelizuma…

This study followed 1,710 people with multiple sclerosis (MS) who were prescribed the medication ocrelizumab as part of their regular care. The goal was to see how well the drug works in real-world settings by tracking changes in symptoms like fatigue, mobility, and cognition, as…

This study tested a small, wearable sensor to see if it could detect early walking and balance problems in people with multiple sclerosis (MS). Researchers compared the sensor's readings to those from a complex, lab-based motion analysis system. The goal was to see if this simple…

This study aimed to find out which of two advanced types of 3 Tesla MRI brain scans is better at detecting active, inflamed lesions in people with multiple sclerosis (MS). Researchers compared two specific scanning techniques in 180 adults with MS who needed a brain scan for thei…

This study tested a new MRI contrast agent called RVP-001, which uses manganese instead of gadolinium, to see if it could safely and effectively detect lesions in the brain and central nervous system. It involved 18 adults with known conditions like brain tumors or multiple scler…

This study tested a new analysis of spinal fluid to see if it can accurately diagnose multiple sclerosis (MS) and distinguish between its different types. It also aimed to find markers that could predict how a person's MS might progress in the future. Researchers analyzed old spi…

This study tested two different types of specialized MRI brain scans to see which one is better at spotting a specific sign of multiple sclerosis (MS). Researchers compared the scans in 60 adults with recently diagnosed MS who were already getting an MRI as part of their regular …

This study tested an online group program designed to help people with multiple sclerosis (MS) prevent falls. 240 participants who had experienced at least one fall in the past year were taught self-management skills over eight virtual sessions. Researchers compared the program g…

This study tested a new online program designed to help people with multiple sclerosis (MS) prevent falls. The program taught self-management strategies during weekly group sessions. Researchers wanted to see if the program was practical and acceptable, and if it helped participa…

This small pilot study tested whether daily bright light therapy could safely help people with multiple sclerosis (MS) sleep better. Researchers wanted to see if this non-drug approach could reduce insomnia and fatigue by potentially resetting the body's internal clock. The study…

This study tested whether a 16-week online exercise coaching program was practical and helpful for people with multiple sclerosis (MS) who use wheelchairs. Researchers enrolled 24 participants to compare the exercise program against a general wellness program. The main goals were…

This study compared two different exercise programs to see which helps people with multiple sclerosis feel better. Twenty MS patients either did gentle yoga or standard physical therapy for eight weeks. Researchers measured their fatigue, balance, walking ability, and overall qua…

This study tested whether a specific pelvic floor muscle exercise program could help women with multiple sclerosis (MS) who experience urinary incontinence. Forty-six women with MS were split into two groups: one group performed the exercises three times daily for three months, w…

This study tested whether a special training method using 3D virtual reality (VR) could help people with multiple sclerosis (MS) improve their arm and hand function. Thirty-two participants with recent MS attacks watched videos of arm movements through VR headsets and then practi…

This study tested whether a combination of gentle, non-invasive brain stimulation (tDCS) and cognitive training exercises could improve memory, attention, and other thinking skills in people with multiple sclerosis (MS). Researchers worked with 45 adults with MS to see if this ap…

This small study tested whether a two-month water exercise program could help people with multiple sclerosis improve their balance and feel less fatigued. Twenty-six participants with a specific type of MS were split into two groups: one did exercises in the sea, and the other di…

This study tested two non-drug approaches to help people with multiple sclerosis manage persistent symptoms like fatigue, pain, and mood issues. 132 participants tried either a comprehensive lifestyle education program, a brain retraining program focused on calming overactive str…

This study tested two different online exercise programs designed to help people with multiple sclerosis manage leg stiffness and muscle tightness (spasticity). The programs were delivered through group video classes to 232 participants. Researchers measured whether these exercis…

This study looked at whether adding cognitive behavioral therapy (a type of talk therapy) to supervised Pilates exercises could help people with multiple sclerosis (MS) improve their walking, balance, and fatigue. It involved 90 adults with MS who could walk independently. One gr…

This study tested whether a 4-month exercise program delivered remotely by coaches could help Hispanic/Latino adults with multiple sclerosis (MS). Researchers wanted to see if the program improved physical function, reduced symptoms like fatigue, and boosted quality of life. They…

This study tested whether a non-invasive electrical brain stimulation treatment could help people with multiple sclerosis (MS) feel better mentally and think more clearly. Fifty-three adults with MS received either the real stimulation or a sham (fake) treatment to see if it impr…

This study tested whether an AI-powered smartphone app could help people with multiple sclerosis (MS) build strength better than traditional paper-based exercise plans. For 20 weeks, 58 participants did strength training three times a week, with one group using the AI app for gui…

This study compared two types of online exercise programs for people with relapsing-remitting multiple sclerosis (MS). Sixteen participants were randomly assigned to either live video sessions with a therapist or pre-recorded exercise videos to follow on their own. Researchers me…

This study looked at whether adding 'motor imagery' (mentally practicing movements) and 'action observation' (watching videos of movements) to standard physical therapy could help people with multiple sclerosis walk better, feel less tired, and improve their balance. It involved …

This study explored whether a single session of stationary bike exercise, especially when combined with virtual reality (VR), could temporarily improve the speed of thinking in people with multiple sclerosis (MS) who have mobility problems. Researchers compared regular cycling to…

This study tested whether a specific type of exercise, called dual-task training, could help people with multiple sclerosis (MS). The training involves doing physical and mental tasks at the same time, like walking while counting backwards. Researchers compared this special train…

This study tested whether laughter yoga could help people with multiple sclerosis (MS) feel better. Forty participants were split into two groups: one did online laughter yoga sessions twice a week for six weeks, while the other did not. Researchers measured changes in fatigue, s…

This study tested whether pelvic floor exercises done at home via video calls could help women with Multiple Sclerosis manage common bladder problems. Researchers compared three types of exercises—strengthening, relaxation, and a combination of both—over 8 weeks. The goal was to …

This study tested whether adding a mild electrical stimulation therapy to standard swallowing exercises helps people with Multiple Sclerosis who have trouble swallowing (dysphagia). 136 participants were randomly assigned to receive either real or fake electrical stimulation alon…

This study tested three different telehealth therapy techniques to help people with multiple sclerosis manage their severe fatigue. Researchers worked with 21 participants to see if relaxation training, activity planning, and thought reframing delivered online were practical and …

This small pilot study tested whether a proven speech therapy program could be delivered effectively through video calls (telerehabilitation) to help people with Multiple Sclerosis (MS) speak louder and more clearly. Twenty participants with MS and voice problems were split into …

This study tested whether a 12-week exercise program called 'movement-to-music' (M2M) could improve fitness and well-being in adults with physical disabilities like spinal cord injury, stroke, or multiple sclerosis. 108 participants were randomly assigned to either start the prog…

This small, completed pilot study tested whether a personalized program combining talk therapy, brain training exercises, and lifestyle advice is practical and helpful for people with thinking problems from conditions like brain injury, multiple sclerosis, or mild memory loss. Th…

This study tested whether an 8-week aerobic exercise program could improve movement and function in people with multiple sclerosis (MS). Thirty adults with MS were randomly assigned to either follow the exercise program or be in a comparison group that did not. The results showed…

This study tested two non-invasive electrical stimulation methods to see if they could ease overactive bladder symptoms in women with Multiple Sclerosis (MS). Forty-two participants were split into groups to receive stimulation on the ankle or lower back, or a sham treatment, twi…

This study tested how easy a new mobile app was to use for people with MS. The app guides users through self-administered acupressure techniques aimed at managing pain and fatigue. Ten adults with MS tried the app for six weeks, and researchers interviewed them about their experi…

This study tested whether following the MIND diet, a plan focused on brain-healthy foods, could help people with multiple sclerosis (MS). For three months, 62 participants either followed the MIND diet or a standard healthy eating plan. Researchers measured if the diet improved t…

This small, completed pilot study tested whether two different types of computerized brain training programs, both paired with light physical activity, could help improve thinking skills like memory and attention in people with multiple sclerosis (MS). Participants used either a …

This study tested whether adding a special core stabilization exercise program to standard pelvic floor muscle training could better improve bladder symptoms and pelvic function in women with multiple sclerosis (MS). Researchers compared the two exercise approaches in 24 women ov…

This study tested whether simple writing exercises focused on gratitude and past successes could help people recently diagnosed with multiple sclerosis (MS) feel more hopeful and improve their emotional well-being. Thirty participants were randomly assigned to either start the ex…

This study aimed to understand how thinking and emotional problems affect walking in people with multiple sclerosis (MS). Researchers measured the walking patterns, eye movements, and muscle activity of 32 MS patients while they performed walking tasks. The goal was to gather kno…

This study looked at how conflict affects healthcare for people with multiple sclerosis in Libya. Researchers examined 369 patients' medical records to understand how long it takes to get diagnosed, who receives effective treatments, and how these delays relate to disability leve…

This early-stage study checked how two common medications (gemfibrozil and rifampicin) affect the way the body processes an experimental drug for multiple sclerosis (SAR442168). It involved 30 healthy male volunteers to measure drug levels and safety. The goal was to understand p…

This study aimed to find a new biological marker (biomarker) in the blood to help monitor multiple sclerosis (MS). Researchers compared blood samples from 100 healthy people and people with stable MS who were on different treatments. They measured the levels of a specific seroton…

This study aimed to understand how the menstrual cycle affects the experience and physical response to exercise in women with multiple sclerosis (MS). Researchers compared 15 women with MS to women without the condition, having them perform high-intensity and strength training se…

This small study aimed to understand how different types of exercise immediately affect the brain and body in people with multiple sclerosis (MS). Researchers compared standard exercises, traditional aerobic exercise, and aerobic exercise using virtual reality (VR) headsets in 12…

This early study aimed to understand how the body processes an experimental drug for multiple sclerosis (SAR442168). Six healthy male volunteers took a single, traceable dose so researchers could measure how much drug was absorbed, how it was broken down, and how it left the body…

This study aimed to understand exactly how the drug cladribine works in people with multiple sclerosis (MS). Researchers tested blood cells from 77 MS patients and healthy donors in the lab to see how the drug affects the immune system and whether it might protect nerve cells. Th…

This study aimed to create personalized mathematical models of how much muscle force people with arm weakness from stroke, multiple sclerosis, or spinal cord injury can still produce. Researchers measured 32 patients' shoulder and elbow strength to understand their remaining abil…

This was a small, completed lab study that tested whether specially engineered versions of a natural immune protein (called IL-2 muteins) could selectively boost a type of calming immune cell (regulatory T cells) taken from patients with various autoimmune and inflammatory diseas…

This study aimed to understand if a specific gene mutation (ABCG2) affects how much of the multiple sclerosis drug teriflunomide stays in a patient's body and its safety. It involved 82 Chinese patients with relapsing multiple sclerosis who took the standard 14 mg dose daily for …

This study aimed to see if a shorter, 6-meter version of a standard walking test works as well as the usual 30-meter version for people with multiple sclerosis (MS). Researchers tested 21 adults with MS to compare the two versions. The goal was to create a test that is easier to …

This study used advanced brain scans to see if the approved MS drug ocrelizumab reduces inflammation in the brain. Researchers scanned 22 patients with multiple sclerosis before and after about a year of standard ocrelizumab treatment. The goal was to understand how the drug work…

This study looked back at medical records to see if people's gender, race, or economic background affected their access to a multiple sclerosis drug called Ocrelizumab and how well the treatment worked for them. Researchers analyzed data from 800 patients at two major hospitals t…

This study aimed to understand why people swing their arms while walking and how this movement is connected to balance and energy use. Researchers observed 25 people, including healthy individuals and those with conditions like stroke, Parkinson's, or multiple sclerosis, while th…

This study looked back to see if the first wave of the COVID-19 pandemic changed how people with multiple sclerosis (MS) reported and received care for their symptom flare-ups (relapses). Researchers compared 51 patients who had a relapse during April-June 2020 with a similar gro…

This study aimed to understand how well the Pfizer COVID-19 vaccine works in adults with weakened immune systems compared to healthy adults. Researchers measured antibody levels in the blood and nose of 196 participants, including people with conditions like cancer, HIV, and orga…

This study tested whether it was practical and acceptable for people with Multiple Sclerosis (MS) to take a daily probiotic drink for 12 weeks. Researchers enrolled 29 UK adults with MS to see if they could stick to the regimen and to explore any early effects on their quality of…

This study was a survey to see if doctors, nurses, and patients with multiple sclerosis (MS) received and understood important safety information about the drug Mayzent. It involved 335 healthcare professionals and patients/caregivers in several European countries and Canada. The…

This study tested whether a combined genetic and environmental risk score could help predict who might develop multiple sclerosis (MS). Researchers studied 181 people with MS and their family members to see if the risk score could identify those at highest risk. The goal was to b…

This study aimed to understand if people with unusual forms of multiple sclerosis (MS) have a different or more severe disease process. Researchers compared blood levels of specific proteins (neurofilament light chain and GFAP) in 15 patients with atypical MS to 30 patients with …

This study looked at how multiple sclerosis (MS) and the medications used to treat it might affect women's fertility. Researchers analyzed blood samples from over 800 women with MS or similar conditions, aged 18-35, to measure a hormone that indicates ovarian reserve. The goal wa…

This study aimed to develop better tools for tracking nerve damage in people showing early signs of multiple sclerosis (MS). Researchers followed 134 patients who had experienced a single neurological episode to see how their condition changed over time. They used eye scans and b…

This study aimed to better understand and measure the severe fatigue experienced by most people with Multiple Sclerosis (MS). Researchers worked with 60 participants who had MS to compare three ways of assessing fatigue: through patient questionnaires (subjective), physical perfo…

This study aimed to understand and describe breathing problems in people with severe multiple sclerosis. Researchers observed 70 patients with advanced MS to measure their breathing function during sleep and while awake. The goal was to gather information about how MS affects bre…

This study tested a new blood test to measure antibodies that some patients develop against the multiple sclerosis drug alemtuzumab. Researchers followed 15 patients for two years to see if these antibodies were linked to side effects, changes in immune cells, or the drug's effec…

This study aimed to learn more about how Multiple Sclerosis (MS) and pregnancy affect each other and a baby's development. Researchers followed 168 women with MS in New England who were pregnant or planning a pregnancy through regular phone interviews. They collected information …

This study aimed to understand if a multiple sclerosis (MS) medication called ocrelizumab passes into breastmilk and affects breastfeeding infants. Researchers measured the drug levels in breastmilk and checked the babies' immune cells and responses to standard childhood vaccines…

This study tested a Turkish version of a questionnaire designed to measure bladder symptoms in people with multiple sclerosis (MS). Researchers worked with 71 Turkish adults diagnosed with MS to see if the survey questions were clear, reliable, and accurately captured their exper…

This study aimed to understand the connection between depression and the ability to recognize facial emotions in people with multiple sclerosis (MS). Researchers compared 38 participants, including MS patients and healthy controls, using emotion recognition tests, brain scans (MR…

This study aimed to understand how the approved MS drug, oral cladribine, changes specific immune cells in the body and spinal fluid over two years. It involved 10 people with relapsing-remitting MS who were already taking the drug. Researchers measured detailed changes in B-cell…

This study looked at how COVID-19 lockdowns in France impacted people with long-term health conditions like heart disease, multiple sclerosis, and cancer. Researchers followed over 1,300 patients to see if lockdowns changed their medication use, lifestyle habits, and access to me…

This study aimed to understand if people with multiple sclerosis (MS) have difficulty recognizing emotions, particularly positive ones. Researchers compared 101 people with a specific form of MS to a group of healthy volunteers. They measured how participants identified emotions …

This study aimed to understand if a multiple sclerosis medication called ocrelizumab passes from a pregnant mother to her baby. Researchers followed 70 infants whose mothers took the drug around the time of pregnancy to check the babies' immune cell levels and see if they respond…

This study tested whether an FDA-approved iron supplement called ferumoxytol could be used as a special dye to make inflammation in the brain show up more clearly on powerful MRI scans. Researchers enrolled 14 adults, some with multiple sclerosis and some healthy, to see if the i…

This study aimed to find better ways to predict if people with early brain scan abnormalities will develop multiple sclerosis (MS). Researchers tested new markers in blood and spinal fluid from 100 people who had these early scan findings. The goal was to see if these markers cou…

This study tested a new walking assessment called the 'L test' in 50 people with Multiple Sclerosis (MS). The goal was to see if this test is a reliable and valid way to measure the common challenge of walking while also thinking or talking, which can increase fall risk. Research…

This study aimed to understand why some people with Multiple Sclerosis (MS) develop liver problems when taking a common drug called beta-interferon. Researchers compared the genes of 300 MS patients who had liver injury with those who did not, using saliva samples. The goal was t…