Can gabapentin or memantine stop the shakes in MS eyes?

NCT ID NCT01744444

Completed Symptom relief Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested two drugs, gabapentin and memantine, in 10 people with multiple sclerosis who have a constant eye shaking called pendular nystagmus. The goal was to see if either drug could reduce the eye movement and improve vision and quality of life. Each person tried both drugs in a random order, and the researchers measured eye speed, clarity of sight, and how bothersome the shaking felt.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: gabapentin and memantine
What this could lead to: If it works, this could point toward a treatment to calm eye shaking and improve vision in people with multiple sclerosis.
What could go wrong: This is a very small, early-phase trial with only 10 participants, so results may not apply to everyone. The drugs may cause side effects or not improve symptoms significantly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis spontaneous ocular nystagmus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PENDULAR NYSTAGMUS PATIENTS WITH MULTIPLE SCLEROSIS

Contacts and locations

Locations

Hôpital Neurologique Unité de Neuro-Ophtalmologie

Bron, 69677, France

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