MULTIPLE SCLEROSIS

This study aims to understand the long-term safety of several medications used to control multiple sclerosis (MS). Researchers will analyze health records from over 10,500 people with MS who are taking drugs like Vumerity or Tecfidera. The main goal is to track and compare the ra…

This study is testing whether an investigational drug called LY3541860 can safely slow the formation of new brain lesions in adults with relapsing forms of multiple sclerosis. About 63 participants will receive either the drug or a placebo for approximately 9 months, followed by …

This study is testing a smartphone app called MS CATCH, which helps people with MS track their mood symptoms. The app shares this information with their neurologist, who can then monitor changes and provide timely support. The goal is to improve how depression is reported, screen…

This study is testing whether a higher dose of the drug ocrelizumab can better slow the worsening of disability in adults with primary progressive multiple sclerosis (PPMS). It compares the new higher dose against the currently approved dose over at least two years. The main goal…

This study is testing whether Truvada, an antiviral medication, can reduce levels of Epstein-Barr virus (EBV) in people with multiple sclerosis (MS). Researchers believe EBV might trigger MS, so lowering the virus could help control the disease. The trial will enroll 50 adults wi…

This study is testing whether N-acetyl cysteine (NAC), an antioxidant supplement, can help protect brain function in people with multiple sclerosis (MS). Researchers will use brain scans to measure changes in brain metabolism and inflammation in 55 MS patients who receive either …

This program provides early access to an experimental oral treatment called CNM-Au8 for up to 25 people with multiple sclerosis. Participants will take the medication daily for 96 weeks while doctors monitor their safety and how well the treatment works. The program is designed f…

This study is testing whether a combination of guided exercise and a fish oil supplement (DHA) can help people with multiple sclerosis. It will involve 100 participants who will be assigned to different groups to see if the exercise, the supplement, or both together are most effe…

This study compares two approaches for people with relapsing multiple sclerosis who have been on anti-CD20 medications. It examines whether switching to a different drug called cladribine might help reduce infection risks while still controlling MS symptoms. The research follows …

This study aims to identify which patients with relapsing multiple sclerosis (RMS) respond best to treatment with cladribine tablets. Researchers will follow 367 adults already taking this medication in real-world settings to see how long they stay on treatment and track their sy…

This study follows 1,300 multiple sclerosis patients who previously received ocrelizumab in earlier trials. Researchers will monitor patients for several years to understand the long-term safety and effectiveness of continued treatment. The study tracks disability progression, wa…

This study is testing whether injecting a patient's own bone marrow stem cells into the spinal fluid can help repair nerve damage and slow the progression of multiple sclerosis (MS). It involves 18 adults with progressive MS, who will receive either the stem cell treatment or a p…

This large, late-stage study is testing whether a higher dose of the approved MS drug ocrelizumab works better than the standard dose at slowing disability progression. It will involve 864 adults with relapsing MS, who will receive intravenous infusions every 24 weeks and be moni…

This program provided special access to the drug siponimod for adults with a specific, active form of progressive multiple sclerosis (SPMS) who had no other satisfactory treatment available. It was not a standard clinical trial but a managed access plan, allowing doctors to reque…

This study tests whether regular multiple sclerosis (MS) care provided through video calls works as well as traditional in-office visits. Researchers are comparing 120 recently diagnosed adults, randomly assigning half to receive check-ups via telehealth and half to continue with…

This study is testing whether multiple infusions of a patient's own stem cells, taken from their fat tissue, can help control multiple sclerosis. It is for up to 10 people with relapsing-remitting MS who were in a previous related study and did not receive the active treatment. T…

This study is testing whether cells taken from a patient's own body fat can help control advanced Multiple Sclerosis (MS). Doctors collect, process, and inject these cells back into the patient's bloodstream, hoping they will reduce brain inflammation and slow disease progression…

This study aims to find out which of two existing multiple sclerosis (MS) medications works better and is safer for children and teenagers aged 10-17. About 240 young patients will take either a daily pill (fingolimod) or a weekly injection (interferon beta-1a) for two years, wit…

This large, late-stage study is testing whether a daily pill called IMU-838 can better control relapsing multiple sclerosis compared to a placebo. It involves over 1,100 adults with active MS and will measure if the drug delays flare-ups, slows disability progression, and reduces…

This study is testing whether a simple smartphone questionnaire can help doctors confirm when someone with multiple sclerosis (MS) is having a true disease relapse. Researchers want to see if this tool, along with better communication with the clinic, can save patients from makin…

This study is looking at what happens when people with relapsing forms of multiple sclerosis (MS) switch from one specific medication (natalizumab) to another (cladribine tablets). It will follow 40 patients for about two years to check the safety of the switch and see how it aff…

This study is testing whether N-acetyl cysteine (NAC), an over-the-counter antioxidant supplement, can slow brain shrinkage in people with progressive multiple sclerosis. 98 participants aged 40-70 with progressive MS will receive either NAC or a placebo for 15 months. Researcher…

This study is testing whether gentle, low-frequency electromagnetic waves can help stabilize the immune system and reduce painful flare-ups in people with autoimmune diseases like lupus, rheumatoid arthritis, and multiple sclerosis. About 120 participants will receive either real…

This study is testing the safety and determining the right dose of the drug ocrelizumab for children and teenagers (ages 10-18) with relapsing-remitting multiple sclerosis (MS). It involves a small group of 23 participants and will last for two years. The main goal is to gather i…

This study observes how well the MS medication Kesimpta (ofatumumab) works for 107 Swiss patients in real-world medical care over 12 months. Researchers will track whether patients show no signs of disease activity, monitor treatment adherence, and measure how the treatment affec…

This study tested whether an investigational antibody drug called SAR441344 can reduce new areas of inflammation (lesions) in the brain for people with relapsing forms of multiple sclerosis (MS). About 129 participants received either the drug or a placebo to compare effectivenes…

This study aims to determine if a new test measuring kappa free light chains (KFLC) in spinal fluid works as well as the current standard test for diagnosing multiple sclerosis (MS) and early MS symptoms. Researchers will compare both tests in 1,142 adults already diagnosed with …

This study is testing whether using artificial intelligence (AI) software to analyze brain MRI scans helps doctors better detect disease activity in people with multiple sclerosis (MS). It will compare 750 patients whose doctors use the AI tool with those who receive standard car…

This study is testing whether smart insoles worn in everyday shoes can help monitor the progression of Multiple Sclerosis (MS) from home. The insoles use sensors and an app to track walking patterns, aiming to detect subtle changes that might signal the disease is getting worse. …

This study is testing if a specific feature seen on MRI scans, called the 'central vein sign,' can help doctors diagnose Multiple Sclerosis (MS) more accurately and quickly. It involves 420 people in North America who have symptoms that are either typical or not typical for MS. T…

This study is testing whether a specific 5-week home exercise program can help prevent falls in people with Multiple Sclerosis (MS). Thirty participants with MS will be randomly assigned to one of two exercise groups to compare their balance, mobility, and fear of falling. The go…

This study is testing whether MitoQ, an antioxidant dietary supplement, can reduce fatigue in people with multiple sclerosis. Forty-five participants with MS and significant fatigue will take either MitoQ or a placebo pill daily for twelve weeks. Researchers will compare fatigue …

This study is testing whether fun virtual reality games in a shared online world (the metaverse) can help people with brain injuries or diseases like stroke, MS, or Parkinson's. The games focus on cooking, puzzles, and social activities to improve memory, attention, and thinking …

This study is testing whether a special education program delivered by nurses can help people with multiple sclerosis (MS) feel better. About 96 participants will receive the education either in-person or by phone/computer. The goal is to see if learning new self-care strategies …

This study is testing whether a home-based, online rehabilitation program is safe and effective for people with multiple sclerosis (MS). Researchers want to see if doing three weekly video sessions improves physical activity, balance, walking, mood, and quality of life compared t…

This study is testing if training to walk backwards can help people with multiple sclerosis (MS) reduce their risk of falling. It will compare backward walking training to standard forward walking training in 90 participants who have MS and walking difficulties. The main goal is …

This study aims to understand how two cannabis components, THC and CBD, affect thinking skills and bladder symptoms in people with Multiple Sclerosis (MS). Thirty participants with MS and bladder issues will be randomly assigned to take either THC or CBD oil daily for 15 weeks. R…

This study is exploring whether a wearable robotic exoskeleton, used as part of a weekly rehab program for a year, can help people with multiple sclerosis maintain their physical strength, walking ability, and overall quality of life. It involves 19 participants who will use the …

This study is testing whether a 16-week remote coaching program can help people newly diagnosed with MS become more physically active. Researchers want to see if increasing activity through online guidance and a Fitbit improves common symptoms like fatigue, depression, and anxiet…

This study is testing a new hybrid exercise program for people with multiple sclerosis (MS). Participants will do 12 weeks of group circuit training with physiotherapists, followed by using a mobile app to track their own physical activities at home. The goal is to see if this co…

This study is testing whether a special training program using a light-up reaction device can help people with Multiple Sclerosis (MS). The goal is to see if this training can improve thinking skills, balance, and walking ability. Researchers will compare a group doing the traini…

This study is testing a smartphone app called MS Falls Insight Track that helps people with multiple sclerosis monitor and prevent falls. The app connects patients' health data with information from wearable devices like Fitbits to track falls in real time. Researchers are checki…

This study is testing if a combination of two treatments can improve muscle strength and nerve signals in people with multiple sclerosis (MS). The treatments are breathing brief, low levels of oxygen and using mild electrical stimulation on the leg. Researchers will measure ankle…

This study is testing whether practicing Qigong, a traditional Chinese mind-body exercise, can help people with multiple sclerosis (MS). Researchers want to see if Qigong improves balance, daily function, depression, and overall well-being compared to standard rehabilitation exer…

This study is testing a 6-month online coaching program designed to help people with multiple sclerosis (MS) become more physically active. Researchers want to see if this program can help participants move more, which may improve their walking, thinking, fatigue, mood, and overa…

This study is testing new rehabilitation exercises that combine physical and mental tasks, like walking while solving a puzzle, to help people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. The goal is to see if these 'dual-task' exercises, often supported b…

This small pilot study is testing whether a home-based coaching program, originally designed for epilepsy, can be adapted to help people with multiple sclerosis (MS). Participants will have nine one-on-one virtual sessions with a coach to learn self-management strategies for memo…

This study is testing a special walking training program that uses visual guides to help people with multiple sclerosis improve their balance and mobility. Researchers want to see if this training can help reduce the risk of falling. The study involves 40 participants who have MS…

This study is testing whether a robotic exoskeleton suit can help improve walking and balance for people with multiple sclerosis (MS). The suit, called HAL, reads signals from the wearer's muscles to assist their movement. Eight participants will use the suit for walking rehabili…

This study is testing whether adding new 'wearable for the bladder' devices to standard pelvic floor physical therapy helps people with multiple sclerosis (MS) manage overactive bladder symptoms. Researchers want to see if using these devices at home for three months is practical…

This study aims to understand how brain inflammation relates to disability progression in multiple sclerosis (MS). Researchers will use specialized PET brain scans on 35 participants with MS, aged 40-50, to measure inflammation and other brain changes. The goal is to find markers…

This study is creating a large collection of blood samples and health information from people with multiple sclerosis and similar conditions. The goal is to give scientists a shared resource to study what causes these diseases and how they progress. Over 3,200 participants have c…

This study aims to understand why many people with multiple sclerosis experience walking fatigue, where their walking worsens over time. Researchers will measure brain activity and walking patterns in 70 people with MS and 30 healthy volunteers during short and prolonged walking …

This study aims to understand how natural hormone changes during the menstrual cycle affect the brain's connection to muscles, the ability to learn new movements, and feelings of fatigue in women with multiple sclerosis (MS). Researchers will measure hormone levels and test brain…

This study aims to understand if and how white blood cells enter the brain in conditions like fibromyalgia, chronic fatigue syndrome, and multiple sclerosis. Researchers will use a special radioactive tracer and PET/MRI scans to track these cells in 120 participants, including he…

This French study aims to understand why multiple sclerosis (MS) progresses differently in different people. Researchers are studying 120 pairs of siblings who both have MS, looking at their genes, immune systems, and brain scans over time. The goal is to find a combination of ma…

This study aims to understand how the stiffness and mechanical properties of muscles in the legs and chest relate to breathing function, fatigue, and feelings of anxiety or depression in people with multiple sclerosis (MS). Researchers will measure these factors in about 58 parti…

This study aims to understand if early signs of brain inflammation in people with Multiple Sclerosis (MS) can predict which brain lesions will grow larger over 10 years. Researchers will follow about 100 MS patients who had a special brain scan years ago, checking their brain hea…

This study aims to validate digital tools for tracking Multiple Sclerosis (MS) progression. Researchers are testing a smartphone app with 300 MS patients to see if it can reliably measure disease activity through daily challenges and monitoring. The goal is to create digital biom…

This study aims to see if a simple walking test can reliably measure how people with Multiple Sclerosis (MS) manage walking while also thinking or carrying something. Researchers will ask 50 participants with MS to perform the test under different conditions, like walking while c…

This study is observing how a mobile app called MSCopilot fits into the daily lives of people with multiple sclerosis (MS) and their doctors. Researchers are tracking 60 patients and their healthcare teams to see how easy the app is to use at home and how well it integrates into …

This study aims to create detailed reference charts of normal brain structure and function for the Chinese population by collecting brain scans from 10,000 healthy people and people with various brain conditions. Researchers will use these charts to help doctors make more accurat…

This study aims to understand how genetics, lifestyle, and other factors influence the progression and severity of many common chronic diseases. Researchers will collect health records, genetic data, and samples from 120,000 participants with conditions like diabetes, arthritis, …

This study aims to use advanced technology to precisely measure balance and walking problems in people with stroke, Parkinson's disease, or multiple sclerosis. Researchers will use a special balance platform and motion-capture sensors to track 60 participants during a rehab progr…

This study aimed to understand how the drug alemtuzumab affects brain inflammation in people with relapsing-remitting multiple sclerosis (MS). Researchers planned to use a special type of brain scan (PET) to measure inflammation before and after treatment. The goal was to learn i…

This study is creating a national registry to track 1,000 people with multiple sclerosis (MS) over time. Researchers will compare how well different approved MS medications work in real-world settings and monitor their safety. The goal is to better understand MS patterns and trea…

This study aims to understand how often patients with relapsing-remitting multiple sclerosis (RRMS) develop antibodies against their treatment, natalizumab, when they switch from receiving it through an IV to a subcutaneous injection. It will observe about 400 patients in Europe,…

This study aims to understand how immune cells differ in the lymphatic system of people with Multiple Sclerosis (MS) compared to healthy people. Researchers will collect lymph fluid from a small group of participants using a minimally invasive tube. They will also check if a stan…

This study aims to better understand specific brain changes, called white matter hyperintensities, seen on MRI scans. Researchers will compare brain images from 50 women with migraines, small vessel ischemic disease, or multiple sclerosis. The goal is to learn more about these co…