MULTIPLE SCLEROSIS

This phase 3 study tests whether the drug frexalimab can delay worsening disability in people with a form of multiple sclerosis called nonrelapsing secondary progressive MS (nrSPMS). About 943 adults aged 18 to 60 are receiving either frexalimab or a placebo for up to 36 months. …

This early-stage study tests an experimental cell therapy called P-CD19CD20-ALLO1 in 60 adults with multiple sclerosis. The main goal is to see if it is safe and how the body handles it. Researchers will also measure how long the cells last and how they affect the immune system.

This study tests whether a higher dose of the drug ocrelizumab can better slow disability progression in people with relapsing multiple sclerosis (MS) compared to the standard dose. About 864 adults with MS will receive either the higher or approved dose every 24 weeks. The main …

This study compares a daily pill (fingolimod) to a weekly injection (interferon beta-1a) in 240 children with multiple sclerosis. The goal is to see which drug better reduces relapses and new brain lesions over two years. Participants must have had recent MS relapses or MRI signs…

This study tests an experimental drug called LY3541860 in 63 adults with relapsing multiple sclerosis (MS). The goal is to see if it can safely reduce new areas of inflammation in the brain compared to a placebo. Participants receive either the drug or a placebo, and brain scans …

This study looks at whether switching from anti-CD20 drugs (like ocrelizumab) to cladribine can improve immune function and lower infection risk in people with relapsing multiple sclerosis. About 70 participants will be followed for 2 years. The goal is to see if the switch helps…

This study tests the safety and dosing of ocrelizumab in 23 children and teens (ages 10–18) with relapsing-remitting multiple sclerosis over 2 years. The goal is to find the right dose for a future larger study. Participants must have a diagnosis of RRMS and stable symptoms befor…

This study tests an experimental drug called SAR441344 in 129 adults with relapsing multiple sclerosis. The drug blocks a protein (CD40L) to reduce new active brain lesions seen on MRI. Participants receive either the drug or a placebo for several weeks. The goal is to see if the…

This study tests whether a special mix of cells taken from a patient's own fat can help control multiple sclerosis (MS). The cells are given through a vein and are thought to calm the immune system and reduce nerve damage. The study looks at safety and whether it improves daily l…

This large Phase 3 study compares a new investigational drug, frexalimab, to an approved daily pill (teriflunomide) in about 1655 adults with relapsing forms of multiple sclerosis. The main goal is to see if frexalimab reduces the number of relapses more effectively. Participants…

This early-phase study tests whether a patient's own stem cells, injected into the spinal fluid, can repair nerve damage in people with progressive multiple sclerosis (MS). The trial involves 18 adults aged 18-55 with moderate to severe disability. The main goal is to see if the …

This study tests whether a higher dose of ocrelizumab can better slow disability progression in adults with primary progressive multiple sclerosis (PPMS). About 769 participants receive either the approved dose or a higher dose every 24 weeks. The main goal is to see if the highe…

This study tests whether the drug IMU-838 can reduce relapses and brain damage in people with relapsing multiple sclerosis (MS). About 1,100 adults aged 18-55 with active MS will receive either IMU-838 or a placebo for up to 72 weeks. The main goal is to see if the drug delays th…

This study tests whether Truvada, an antiviral drug used for HIV, can reduce levels of Epstein-Barr virus (EBV) in people with multiple sclerosis (MS). EBV is linked to MS, and lowering it might help control the disease. About 50 adults with MS who have evidence of past EBV infec…

This study follows about 1,300 people with multiple sclerosis who are already taking ocrelizumab to see how safe and effective it is over the long term. Participants continue their treatment and are checked for side effects, disability changes, and brain lesion activity. The goal…

This program offers up to 25 adults with multiple sclerosis access to an experimental drug called CNM-Au8. The goal is to provide treatment for those who have no other options. It is not a cure, but aims to help control the disease.

This program provides access to the drug siponimod for adults with secondary progressive multiple sclerosis (SPMS) whose disease is still active and who have no other good treatment options. The goal is to help control the disease and slow progression. Patients must meet specific…

This study looks at whether people with relapsing-remitting or active secondary progressive multiple sclerosis can safely switch from natalizumab to cladribine tablets. About 40 adults aged 18-60 will be followed for up to 24 months to check immune cell changes, nerve damage mark…

This study looks at whether people over 50 with a stable, inactive form of secondary progressive multiple sclerosis can stop taking their disease-modifying therapy without worsening their disability. Researchers will follow 250 participants for two years to compare disability pro…

This study tests a non-invasive device that uses low-frequency electromagnetic waves to help immune cells communicate better. The goal is to reduce flare-ups in people with lupus, rheumatoid arthritis, or multiple sclerosis. 120 adults will receive either real or placebo sessions…

This early-stage study tests a single dose of IMS001, a stem cell therapy made from human embryonic cells, in 30 adults with multiple sclerosis (MS) who did not get better with standard treatments. The main goal is to check if the treatment is safe and tolerable. Researchers will…

This early-stage study aimed to test the safety of a new treatment called GC012F for people with multiple sclerosis. The treatment uses specially engineered immune cells (CAR T cells) to target the disease. However, the study was withdrawn before enrolling any participants, so no…

This study tests whether N-acetyl cysteine (NAC), a supplement, can protect the brain in people with progressive multiple sclerosis (MS). About 98 adults with primary or secondary progressive MS will receive either NAC or a placebo for 15 months. Researchers will measure brain sh…

This study tests a new stem cell treatment (HB-adMSCs) for people with relapsing-remitting multiple sclerosis (RRMS). The goal is to see if multiple infusions of the patient's own stem cells can improve quality of life and reduce disability. Ten adults who previously received a p…

This study is testing whether a protein called kappa free light chains (KFLC) in spinal fluid can help diagnose multiple sclerosis (MS) as accurately as the current standard test. Researchers will compare results from over 1,100 adults diagnosed with MS or a first MS-like episode…

This study tests whether a specific brain MRI feature called the central vein sign can improve the accuracy of multiple sclerosis (MS) diagnosis. About 1 in 5 people diagnosed with MS are later found not to have it, leading to unnecessary and risky treatments. Researchers will sc…

This study aims to create detailed brain charts for the Chinese population by collecting MRI scans from over 10,000 healthy volunteers of all ages. These charts will show what a normal brain looks like at different ages, helping doctors spot diseases like multiple sclerosis, Alzh…

This study looks at whether N-acetyl cysteine (NAC), an antioxidant supplement, can help support brain function in people with multiple sclerosis (MS). Researchers will use special PET-MRI scans to measure changes in brain metabolism and inflammation. The study involves 55 adults…

This study tests a 6-month online program designed to help people with multiple sclerosis (MS) increase their physical activity. Researchers want to see if the program improves walking, thinking, fatigue, mood, and quality of life. About 280 adults with MS who are not very active…

This study looks at how two parts of cannabis, THC and CBD, affect thinking and bladder problems in people with Multiple Sclerosis (MS). Thirty adults with MS will take either THC or CBD oil for 15 weeks and complete thinking tests and bladder symptom questionnaires. The goal is …

This study tests a special walking training that uses visual cues to help people with multiple sclerosis (MS) improve their balance, mobility, and reduce fall risk. Forty adults with relapsing-remitting MS who can walk without aids will participate. The training involves walking …

This study looks at whether combining a specific exercise program with a long-term DHA (a type of omega-3 found in fish oil) supplement can help people with multiple sclerosis. The researchers will measure changes in strength, balance, thinking, fatigue, and quality of life in 10…

This study tests a 16-week home-based exercise program for people diagnosed with multiple sclerosis within the last two years. The goal is to see if the program helps them become more active and improves fatigue, mood, and quality of life. Participants wear an activity tracker an…

This study tests whether doing physical therapy sessions at home through video calls can improve balance and quality of life for people with multiple sclerosis or Parkinson's disease. Thirty-six participants will complete 20 balance-training sessions either via telerehabilitation…

This study explores whether backward walking training can improve balance and reduce fall risk in people with multiple sclerosis (MS). About 90 participants with MS who have walking problems or a history of falls will be assigned to either backward or forward walking training. Th…

This study tests whether a digital cognitive behavioral therapy program for insomnia can improve sleep, reduce fatigue, and ease psychological distress in people with multiple sclerosis. 550 adults with MS and insomnia will be randomly assigned to either the online therapy or dig…

This study tests whether combining a home exercise program with a non-invasive brain stimulation technique called tDCS can reduce fatigue in people with multiple sclerosis. Sixty participants will be split into two groups: one gets exercise plus real tDCS, the other gets exercise…

This study tests a smartphone app called MS CATCH that lets people with multiple sclerosis regularly report their mood symptoms. The information is shared with their neurologist, who gets alerts if there are concerns. The goal is to improve depression screening and care. About 10…

This study tests whether special education from a nurse—either in person or through video calls—can help people with multiple sclerosis (MS) manage common problems like fatigue, pain, poor sleep, and urinary tract infections. About 96 adults with relapsing-remitting MS will take …

This small pilot study is testing whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted to help people with multiple sclerosis (MS) who have memory and thinking difficulties. Eleven participants will work one-on-one with a coach in nine v…

This study explores whether using the ABLE Exoskeleton once a week for a year can help people with multiple sclerosis maintain their physical and mental health. Nineteen adults with MS will take part in 60-minute gait training sessions and be tested every three months. The goal i…

This study tests whether using a wearable bladder device along with standard pelvic floor therapy at home can help people with multiple sclerosis (MS) who have overactive bladder symptoms. About 20 women with MS will use the device and therapy for three months. The main goal is t…

This study looks at whether a mix of in-person group exercise and at-home telerehabilitation can help people with multiple sclerosis improve their balance and walking. About 50 adults with MS will take part in a 12-week program with weekly group sessions led by two physiotherapis…

This study tests whether a 5-week home exercise program can help people with multiple sclerosis (MS) improve their balance and prevent falls. Thirty adults with MS will be split into two groups: one doing a standard exercise program and the other doing an enhanced version with ex…

This study looks at whether a technology-supported reaction system can improve agility, thinking, and walking in people with multiple sclerosis (MS). About 40 adults with MS, ages 18-55, who have mild disability will take part. The training aims to sharpen reaction time and balan…

This study tests whether a robotic leg brace called the Hybrid Assistive Limb (HAL) can improve walking and balance in people with multiple sclerosis. Eight participants will use the HAL for one hour a day, five days a week, for two months. Their walking speed, endurance, and bal…

This study is testing a smartphone app called MS Falls Insight Track (MS FIT) that helps people with multiple sclerosis log falls and near-falls, view their health data, and share information with their care team. The goal is to see if using the app can reduce falls and improve c…

This study tests a cognitive rehabilitation program called CIRCuiTS, adapted for people with Multiple Sclerosis (MS). Twenty-four participants will be randomly assigned to start the program immediately or after a 13-week wait. The program involves up to 36 hours of therapist-led …

This study tests whether a tele-rehabilitation program is safe and helpful for people with multiple sclerosis who have mild to moderate disability. 75 participants will do three online rehab sessions per week and attend follow-up visits. Researchers will compare this to standard …

This study looks at whether qigong, a gentle exercise that combines movement, breathing, and focus, can help people with multiple sclerosis (MS) improve their balance, daily function, and mood. About 36 adults with MS will be randomly assigned to do qigong or standard rehabilitat…

This study is testing a set of virtual reality games (exergames) in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. The games include cooking together, solvi…

This study tested two ways of teaching nursing students about multiple sclerosis (MS). One group watched a 360-degree video about the brain and MS, while the other saw a slideshow with the same information. About 50 students from three nursing schools took part. Researchers measu…

This study uses advanced MRI scans to better understand white matter hyperintensities (bright spots on brain images) found in women with migraines. Researchers will compare these spots to those seen in other conditions like small vessel disease and multiple sclerosis. The goal is…

This study looks at how different patterns of deep brain stimulation (DBS) affect movement and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test various stimulation patterns to find which ones work best for…

This study is testing whether a new type of MRI can predict memory and thinking problems in people with multiple sclerosis (MS). Researchers will scan the brains of 75 adults with MS and compare the images to their performance on thinking tests. The goal is to find better ways to…

This study looks at whether overactive immune cells in the brain (microglia) cause MS lesions to grow faster. Researchers will follow 100 people with MS for 10 years, using brain scans to track changes. The goal is to understand how these cells affect disease progression, not to …

This study uses a special radioactive tracer and PET/MRI scans to track white blood cells in the brain. Researchers want to see if these cells enter the brain in people with multiple sclerosis, fibromyalgia, or chronic fatigue syndrome, compared to healthy volunteers. The goal is…

This study looks at whether a special breathing technique (AIH) combined with mild electrical stimulation (NMES) can improve brain signals and ankle strength in people with relapsing forms of multiple sclerosis. About 40 participants will be tested to see if the combination works…

This study aims to find a set of markers—from genes, immune system, and brain scans—that are linked to how severe multiple sclerosis (MS) becomes. Researchers will follow 120 people with MS and their siblings who also have the condition. The goal is to better understand why some …

This study explores whether combining physical and mental tasks (like walking while solving a puzzle) can improve rehabilitation for people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will test these strategies in small groups to see if they a…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study tests two new digital tools—DigiMotion and DigiBalance—that use cameras to measure movement, balance, and stability in people with Multiple Sclerosis (MS). It also uses eye scans to track nerve health. The goal is to see if these tools are as reliable as standard tests…

This study tests whether smartphone app data can reliably track multiple sclerosis (MS) progression. Researchers will compare digital measurements from 300 people with MS to standard clinical tests over two years. The goal is to develop better, more convenient ways to monitor the…

This study follows 200 people with Parkinson's disease or multiple sclerosis for one year. Participants use a smartphone app to track their daily steps and exercise. The goal is to learn how physical activity and confidence in exercising change over time, without providing any tr…

This study tests whether virtual telehealth visits work as well as in-person clinic visits for people with multiple sclerosis (MS). About 120 adults with a recent MS diagnosis will be randomly assigned to either virtual or in-person care for 24 months. Researchers will track disa…

This study follows 440 people with relapsing-remitting multiple sclerosis for 5 to 10 years after their diagnosis. Researchers will use brain scans and other tests to see how the disease changes over time and what factors predict its course. No new treatments are being tested—the…

This study will follow 1,000 adults with multiple sclerosis (MS) who are starting a new MS medication. Researchers will track side effects, relapses, and daily function over time to see how well different treatments work in routine medical practice. The goal is to gather real-wor…

This early-phase study looks at whether liraglutide (Saxenda®), a drug used for weight loss, can increase a brain-protective protein called BDNF in people with multiple sclerosis, long-COVID, or acute leukemia (in remission) who also have obesity and memory or thinking problems. …

This study involves 150 people with relapsing-remitting multiple sclerosis (MS) and their doctors. The goal is to create a questionnaire that can confirm MS relapses without requiring an in-person visit, saving patients time and travel. Researchers will also test if better commun…

This study was designed to test whether a smartphone app could accurately monitor multiple sclerosis (MS) symptoms and progression from home. It planned to enroll adults with MS who would use the app and undergo periodic clinical tests. However, the study was withdrawn before any…

This study looks at whether special brain scans can help predict if multiple sclerosis (MS) will get worse over time. Researchers will scan the brains of 35 people with MS, aged 40 to 50, to measure certain proteins linked to brain inflammation. The goal is to find a way to ident…

This study looks at how natural changes in sex hormones during the menstrual cycle impact brain-to-muscle communication, motor learning, and fatigue in women with multiple sclerosis (MS). Researchers will measure hormone levels and use non-invasive brain stimulation to understand…

This study looks at how much of the multiple sclerosis drug ofatumumab passes into breast milk. It involves 24 breastfeeding women with relapsing MS who start or restart the drug 2-24 weeks after giving birth. Researchers will collect milk and blood samples to measure drug levels…

This study was designed to collect walking data from people with Parkinson's disease, dementia, multiple sclerosis, and other conditions using special sensors worn during daily activities. The goal was to use this data to improve remote diagnosis and fall prevention. However, the…

This study tests whether an AI tool (icobrain mr) that analyzes brain MRI scans can help doctors spot signs of active multiple sclerosis (MS) more accurately than standard scans alone. About 750 adults with MS or early warning signs (RIS/CIS) will be split into two groups: one wh…

This study looks at how people with multiple sclerosis and their doctors use a mobile app called MSCopilot to track the disease at home. Researchers want to see if the app is easy to use and fits smoothly into regular doctor visits. About 60 adults with MS will use the app and gi…

This study looks at whether the Timed Up and Go (TUG) test, a common walking test, can reliably measure how people with multiple sclerosis (MS) perform when they have to walk and think at the same time. About 50 volunteers with MS will do the TUG test alone and while doing simple…

This study was designed to see if the drug alemtuzumab reduces activity of certain brain immune cells (microglia) in people with relapsing-remitting multiple sclerosis. Researchers planned to use special PET scans to measure changes over 18 months. However, the study was withdraw…

This study looks at how many people with multiple sclerosis (MS) develop antibodies against the drug natalizumab when they receive it as an injection under the skin. Researchers will track about 400 patients from European MS registries, including both those new to the drug and th…

This study looks at why people with multiple sclerosis (MS) often feel their walking gets worse the longer they walk. Researchers will measure brain activity and walking patterns in 70 people with MS and 30 healthy volunteers. The goal is to understand how the brain controls walk…

This study collects information from doctors and their multiple sclerosis (MS) patients in real-world clinics across the UK, France, Germany, Italy, Spain, China, Japan, and Brazil. The goal is to see how satisfied patients and physicians are with current MS treatments and what f…

This study tests a wearable smart insole and phone app to monitor walking changes in people with multiple sclerosis (MS) at home. About 90 adults with MS will use the device three times a week for six months. The goal is to see if the technology can reliably detect changes in gai…

This study uses data from large MS registries to monitor the long-term safety of Vumerity and Tecfidera in about 10,500 people with multiple sclerosis. Researchers will compare serious side effects like infections and cancer among those taking these drugs versus other MS treatmen…

This study collects lymph fluid from the chest of 24 people (some with MS, some healthy) to compare immune cells in the blood versus deep in the lymphatic system. In MS participants, researchers will also look at how these cells change after treatment with the approved drug ofatu…

This study looks at how being overweight or obese might make multiple sclerosis (MS) worse in children. Researchers will compare brain scans and blood tests from 58 kids with MS—half of normal weight and half overweight—to see if obesity leads to more inflammation and brain shrin…

This study looks at balance and walking problems in people with stroke, Parkinson's disease, or multiple sclerosis. Researchers will use special devices to measure how stable patients are and how they walk. The goal is to better understand these issues so that rehabilitation can …

This study looks at how the stiffness of leg and breathing muscles affects lung function, fatigue, and anxiety or depression in people with multiple sclerosis (MS). About 29 adults with MS will have their muscle properties measured with a device called MyotonPRO, along with breat…

This study follows 367 adults with relapsing multiple sclerosis to find out which patient traits predict how well cladribine tablets work and how safe they are in everyday practice. Researchers will track how long people stay on the drug, relapses, and other outcomes over time. T…

This study looks at how multiple sclerosis (MS) symptoms, like fatigue and thinking problems, change during different times of the menstrual cycle. About 300 females with MS will track their symptoms and cycle using a phone app for six months. The goal is to find patterns that co…

This study creates a large collection of blood samples and health data from over 3,200 people with multiple sclerosis and similar conditions like transverse myelitis and optic neuritis. The goal is to provide researchers with a shared resource to study causes, subtypes, and bioma…