Immune cell therapy aimed at autoimmune diseases hits early snag
NCT ID NCT06548620
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial planned to test a one-time infusion of genetically modified immune cells (CAR-T cells) targeting CD19 in people with several autoimmune diseases, including lupus and multiple sclerosis. The goal was to see if it was safe and could reduce harmful antibodies. However, the study was withdrawn before any participants were enrolled, so no results are available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CD19-targeted CAR-T cells
What this could lead to
If successful, this approach could offer a new way to control autoimmune diseases by resetting the immune system, potentially reducing reliance on lifelong medications.
What could go wrong
This trial was withdrawn before any patients enrolled, so no data exists. CAR-T therapy carries serious risks like cytokine release syndrome and infections, and its long-term safety in autoimmune diseases is unknown.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 461499, China