SLE

This early-stage study is testing the safety of an experimental drug called CLN-978 in people with moderate to severe lupus. The drug is given as an injection under the skin. Researchers will enroll 24 participants whose lupus remains active despite trying at least two standard t…

This study is testing whether an experimental drug called VENT-03 can reduce the severity of skin rashes caused by lupus. About 24 adults with active lupus skin rashes will take either VENT-03 or a placebo for 4 weeks, then all will take VENT-03 for 8 more weeks. Researchers will…

This early-stage study is testing a new type of cell therapy called RD06-05 for people with active autoimmune diseases. The therapy involves modifying a patient's own immune cells (CAR-T cells) to target and remove harmful immune cells, aiming to reset the immune system. The main…

This early-stage study is testing a new oral drug called ONTO1 for people with lupus, including a serious kidney complication called lupus nephritis. The main goal is to find the highest safe dose and see if it helps improve symptoms when taken alongside standard lupus medication…

This early-stage study is testing a new, one-time cell therapy called RD06-05 for people with serious autoimmune diseases like lupus and vasculitis. The therapy, known as CAR-T, involves modifying a patient's own immune cells to target and remove the harmful cells causing the dis…

This early-stage study is testing a new drug called APG-2575 for people with mild-to-moderate lupus. The main goals are to check if the drug is safe, see how the body processes it, and get a first look at whether it might help control lupus disease activity. About 40 participants…

This study is testing a personalized cell therapy called CART19 for adolescents and young adults with severe lupus that hasn't responded to standard treatments. Doctors will collect a patient's own immune cells, modify them to target lupus-causing B cells, and reinfuse them. The …

This early-stage study is testing a new drug called SAR448501 in adults with moderate-to-severe lupus or rheumatoid arthritis who haven't gotten enough relief from their current treatments. The main goal is to find safe dose levels and see how the drug behaves in the body. About …

This early-stage study is testing whether adding a single injection of stem cells from umbilical cords to standard lupus treatment is safe and tolerable. It will involve 10 adults with active lupus to see if the therapy can reduce disease activity and improve kidney function. The…

This study aims to understand if pregnancy complications or other health signs might appear before a woman is diagnosed with lupus (SLE). Researchers will look back at the medical records of 50 women who had at least one pregnancy before their lupus diagnosis. The goal is to see …