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New ocrelizumab formula under study for MS patients

NCT ID NCT07074886

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 07, 2026 · Updated 4 times

Summary

This study compares two versions of the drug ocrelizumab given as a shot under the skin in people with multiple sclerosis. The goal is to see if the new test version works the same as the current one. About 182 participants with relapsing or primary progressive MS will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ocrelizumab
What this could lead to
If successful, this could confirm that a new formulation of ocrelizumab works as well as the current one, potentially offering more options for MS treatment.
What could go wrong
This is an early phase 2 study focused on bioequivalence, not on proving the drug works better. It may not lead to any change in treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis primary progressive multiple sclerosis relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS

Contacts and locations

Locations

  • AO.U. Policlinico Riuniti Foggia

    Foggia, Apulia, 71100, Italy

  • AOU dell Universita degli Studi della Campania Luigi Vanvitelli Piazza Luigi Miraglia 2

    Naples, Campania, 80131, Italy

  • Advanced Neurology of Colorado, LLC

    Fort Collins, Colorado, 80528, United States

  • CHU de Nimes - Hopital Universitaire Caremeau

    Nîmes, 30900, France

  • Centro de Especialidades Neurológicas y Rehabilitación - CENyR

    CABA, Buenos Aires, C1424BYD, Argentina

  • Centro de Investigacion en Enfermedades Reumaticas CIER

    Ciudad Autonoma Buenos Aires, C1055AAF, Argentina

  • Centro de Pesquisas Clinicas - CPCLIN

    São Paulo, São Paulo, 01244-030, Brazil

  • Centrum Neurologii Krzysztof Selmaj

    Lodz, 90-324, Poland

  • Charite - Universitätsmedizin Berlin

    Berlin, 12203, Germany

  • Clinica Neurológica e Neurocirúrgica de Joinville

    Joinville, Santa Catarina, 89202-165, Brazil

  • Cpn - Centro de Pesquisa Neurologica Porto Alegre Ltda

    Porto Alegre, Rio Grande do Sul, 90110-000, Brazil

  • Focus CECIC

    CABA, CABA / Buenos Aires, C1425BKU, Argentina

  • Fond. Istituto Neurologico C.Besta

    Milan, Lombardy, 20133, Italy

  • Hope Neurology

    Knoxville, Tennessee, 37922, United States

  • Hospital General Universitario de Albacete

    Albacete, DUMMY_VALUE, Spain

  • Hospital General Universitario de Alicante

    Alicante, 03010, Spain

  • Hospital Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Universitari Vall dHebron (CEMCAT)

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41007, Spain

  • Hospital Universitario Virgen de Arrixaca

    EL Palmar (EL Palmar), Murcia, 30120, Spain

  • Hospital Universitario de la Princesa

    Madrid, 28006, Spain

  • Hospital de Gran Canaria Dr. Negrín

    Las Palmas de Gran Canaria, LAS Palmas, 35010, Spain

  • Hôpital Guillaume et René Laënnec

    Nantes, 44805, France

  • IBISMED Wielospecjalistyczne Centrum Medyczne

    Zabrze, 41-800, Poland

  • IME - Instituto Médico Especializado

    Buenos Aires, C1405BCH, Argentina

  • INECO Neurociencias Orono

    Rosario, Santa Fe Province, S2000DTC, Argentina

  • IRCCS Istituto Neurologico Neuromed

    Pozzilli, Molise, 86077, Italy

  • Inovacion y Desarrollo en ciencias de la salud

    Mexico City, Mexico CITY (federal District), 14090, Mexico

  • Instituto de Neurologia de Curitiba

    Curitiba, Paraná, 81210-310, Brazil

  • Instituto do Cerebro do Rio Grande do Sul

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Johns Hopkins University School Of Medicine

    Baltimore, Maryland, 21287, United States

  • NCL Institute Neuroscience

    Rome, Lazio, 00178, Italy

  • Neurocentrum Bydgoszcz sp z o.o

    Bydgoszcz, 85-796, Poland

  • Neurociencias Estudios Clinicos S.C.

    Culiacán, Sinaloa, 80020, Mexico

  • Neurociencias Prisma, A.C

    San Luis Potosí City, San Luis Potosí, 78216, Mexico

  • Neurology Associates PA

    Maitland, Florida, 32751, United States

  • Nmedis sp. z o.o.

    Rzeszów, 35-323, Poland

  • Policlinico Tor Vergata Dip. Neuroscienze-Clinica Neurologica-UOSD Sclerosi Multipla

    Rome, Lazio, 00133, Italy

  • ProNeuro Centrum Medyczne

    ?ory, 44-240, Poland

  • Profound Research, LLC

    Carlsbad, California, 92011, United States

  • SUNY Upstate Medical University

    Syracuse, New York, 13210, United States

  • Sanatorio del Sur S.A.

    San Miguel de Tucumán, T4000IDK, Argentina

  • Santa Casa de Misericordia de Salvador

    Salvador, Estado de Bahia, 40050-410, Brazil

  • St. Josef-Hospital, Klinik für Neurologie

    Bochum, 44791, Germany

  • Swedish Medical Center

    Seattle, Washington, 98104, United States

  • University of Massachusetts Medical School

    Worcester, Massachusetts, 01605, United States

  • University of South Florida

    Tampa, Florida, 33612, United States

  • Università degli studi della Campania Luigi Vanvitelli

    Naples, Campania, 80138, Italy

  • Universitätsklinikum "Carl Gustav Carus", Zentrum für Klinische Neurowissenschaften

    Dresden, 01307, Germany

  • Universitätsklinikum Tübingen, Zentrum für Neurologie

    Tübingen, 72076, Germany

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