Could CAR t cells tame autoimmune brain diseases?

NCT ID NCT06220201

Ongoing Disease control Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 6 times

Summary

This early-stage trial tests a new treatment called CC-97540, which uses a patient's own immune cells engineered to target and destroy harmful immune cells. The study includes 120 people with relapsing or progressive multiple sclerosis or refractory myasthenia gravis. The main goal is to check safety and find the right dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CC-97540 (CAR T cells targeting CD19)
What this could lead to: If successful, this could lead to a new treatment option that controls autoimmune neurological diseases like MS and myasthenia gravis by targeting faulty immune cells.
What could go wrong: This is an early Phase 1 trial focused on safety, so it is too soon to know if it works. CAR T cell therapy can cause serious side effects like cytokine release syndrome.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis multiple sclerosis myasthenia gravis relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS MYASTHENIA GRAVIS

Contacts and locations

Locations

Antwerp University Hospital

Edegem, Antwerpen, 2650, Belgium
Barts Health NHS Trust

London, E1 1RD, United Kingdom
Cleveland Clinic Mellen Center

Cleveland, Ohio, 44195, United States
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hopital Claude Huriez - CHU de Lille

Lille, Nord, 59000, France
Hospital Clínic de Barcelona

Barcelona, Catalunya [Cataluña], 08036, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [Barcelona], 08035, Spain
Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain
Hospital Universitario Ramón y Cajal

Madrid, Madrid, Comunidad de, 28034, Spain
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Klinikum der Universität München Großhadern

München, 81337, Germany
Local Institution - 0005

Boston, Massachusetts, 02114, United States
Local Institution - 0011

Birmingham, Alabama, 35294, United States
Local Institution - 0016

Barcelona, Barcelona [Barcelona], 08035, Spain
Local Institution - 0033

Düsseldorf, 40225, Germany
Manchester Royal Infirmary

Manchester, Lancashire, M20 2RZ, United Kingdom
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Neurological Institute of New York

New York, New York, 10032, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Pitie Salpetriere University Hospital

Paris, Ville de Paris, 75013, France
Salford Royal Hospital

Salford, Manchester, M6 8HD, United Kingdom
Swedish Medical Center

Seattle, Washington, 98122, United States
UZ Gent

Ghent, Oost-Vlaanderen, 9000, Belgium
Universitaetsklinikum Erlangen

Erlangen, 91054, Germany
Universitaetsklinikum Essen

Essen, North Rhine-Westphalia, 45147, Germany
Universitaetsklinikum Magdeburg

Magdeburg, Saxony-Anhalt, 39120, Germany
University College London Hospital

London, London, City of, NW1 2PG, United Kingdom
University of California, Irvine

Irvine, California, 92697, United States
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Yale-New Haven Hospital

North Haven, Connecticut, 06473, United States

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