Could CAR t cells tame autoimmune brain diseases?
NCT ID NCT06220201
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This early-stage trial tests a new treatment called CC-97540, which uses a patient's own immune cells engineered to target and destroy harmful immune cells. The study includes 120 people with relapsing or progressive multiple sclerosis or refractory myasthenia gravis. The main goal is to check safety and find the right dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CC-97540 (CAR T cells targeting CD19)
What this could lead to
If successful, this could lead to a new treatment option that controls autoimmune neurological diseases like MS and myasthenia gravis by targeting faulty immune cells.
What could go wrong
This is an early Phase 1 trial focused on safety, so it is too soon to know if it works. CAR T cell therapy can cause serious side effects like cytokine release syndrome.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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Antwerp University Hospital
RECRUITINGEdegem, Antwerpen, 2650, Belgium
Contact Phone: •••-•••-••••
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Barts Health NHS Trust
RECRUITINGLondon, E1 1RD, United Kingdom
Contact Phone: •••-•••-••••
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Cleveland Clinic Mellen Center
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-••••
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Colorado Blood Cancer Institute
RECRUITINGDenver, Colorado, 80218, United States
Contact Phone: •••-•••-••••
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
Contact Phone: •••-•••-••••
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Hopital Claude Huriez - CHU de Lille
RECRUITINGLille, Nord, 59000, France
Contact Phone: •••-•••-••••
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Hospital Clínic de Barcelona
RECRUITINGBarcelona, Catalunya [Cataluña], 08036, Spain
Contact Phone: •••-•••-••••
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Hospital Universitari Vall d'Hebron
RECRUITINGBarcelona, Barcelona [Barcelona], 08035, Spain
Contact Phone: •••-•••-••••
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Hospital Universitari i Politecnic La Fe
RECRUITINGValencia, 46026, Spain
Contact
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Hospital Universitario Ramón y Cajal
RECRUITINGMadrid, Madrid, Comunidad de, 28034, Spain
Contact Phone: •••-•••-••••
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
Contact Phone: •••-•••-••••
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Klinikum der Universität München Großhadern
RECRUITINGMünchen, 81337, Germany
Contact Phone: •••-•••-••••
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Local Institution - 0005
COMPLETEDBoston, Massachusetts, 02114, United States
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Local Institution - 0011
ACTIVE_NOT_RECRUITINGBirmingham, Alabama, 35294, United States
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Local Institution - 0016
NOT_YET_RECRUITINGBarcelona, Barcelona [Barcelona], 08035, Spain
Contact
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Local Institution - 0033
COMPLETEDDüsseldorf, 40225, Germany
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Local Institution - 0039
WITHDRAWNNew Orleans, Louisiana, 70121, United States
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Manchester Royal Infirmary
RECRUITINGManchester, Lancashire, M20 2RZ, United Kingdom
Contact Phone: •••-•••-••••
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact Phone: •••-•••-••••
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Neurological Institute of New York
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-••••
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Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-••••
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Pitie Salpetriere University Hospital
RECRUITINGParis, Ville de Paris, 75013, France
Contact Phone: •••-•••-••••
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Salford Royal Hospital
RECRUITINGSalford, Manchester, M6 8HD, United Kingdom
Contact Phone: •••-•••-••••
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Swedish Medical Center
RECRUITINGSeattle, Washington, 98122, United States
Contact Phone: •••-•••-••••
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UZ Gent
RECRUITINGGhent, Oost-Vlaanderen, 9000, Belgium
Contact Phone: •••-•••-••••
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Universitaetsklinikum Erlangen
RECRUITINGErlangen, 91054, Germany
Contact Phone: •••-•••-••••
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Universitaetsklinikum Essen
RECRUITINGEssen, North Rhine-Westphalia, 45147, Germany
Contact Phone: •••-•••-••••
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Universitaetsklinikum Magdeburg
RECRUITINGMagdeburg, Saxony-Anhalt, 39120, Germany
Contact Phone: •••-•••-••••
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University College London Hospital
RECRUITINGLondon, London, City of, NW1 2PG, United Kingdom
Contact Phone: •••-•••-••••
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University of California, Irvine
RECRUITINGIrvine, California, 92697, United States
Contact Phone: •••-•••-••••
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University of Cincinnati Medical Center
RECRUITINGCincinnati, Ohio, 45219, United States
Contact Phone: •••-•••-••••
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University of Colorado Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-••••
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University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
Contact Phone: •••-•••-••••
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-••••
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Yale-New Haven Hospital
RECRUITINGNorth Haven, Connecticut, 06473, United States
Contact Phone: •••-•••-••••