MS crystal ball: new biomarkers aim to predict disability before it strikes

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

For MS patients: * Inclusion Criteria: * The patient must be already included in the OFSEP High Definition cohort (NCT03603457). * The patient must have given his informed and signed consent for the inclusion in the VHD cohort. * The patient must be insured or beneficiary of a health insurance plan. * Exclusion Criteria: * The patient is under judicial protection. * The patient refuses to sign the consent. * It is impossible to correctly inform the patient (Inability to understand the study, language problem). * The patient has experienced a relapse in the previous 3 months. * The patient is pregnant or breast-feeding (MRI contraindicated). * Patient with MRI contra-indications (patient with a pacemaker, ferromagnetic vascular clip, infusion pump, neurostimulator, cochlear implants or in whom there is a suspicion of a metallic foreign body). * The patient has a severe psychiatric illness * The patient has severe chronic alcoholism For healthy subjects: * Inclusion Criteria: * The healthy subject must be older than 18 years * The healthy subject must have given his informed and signed consent for the inclusion in the VHD cohort. * The healthy subject must be insured or beneficiary of a health insurance plan. * Exclusion Criteria: * The healthy subject is under judicial protection. * It is impossible to correctly inform the healthy subject (Inability to understand the study, language problem). * The healthy subject is pregnant or breast-feeding (MRI contraindicated). * The healthy subject has MRI contra-indications (a pacemaker, ferromagnetic vascular clip, infusion pump, neurostimulator, cochlear implants or in whom there is a suspicion of a metallic foreign body). * The healthy subject has a history of disease that may affect the central nervous system. * The healthy subject has a family history of MS.