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Scientists aim to create a universal rulebook for spotting aggressive MS lesions on MRI

NCT ID NCT07705581

Ongoing Knowledge-focused Sponsor: IRCCS San Raffaele Source: ClinicalTrials.gov ↗

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This study looks at how consistently doctors can identify paramagnetic rim lesions (PRLs) on MRI scans of people with multiple sclerosis. PRLs are a sign of more active and aggressive disease. By having experts from 15 centers review the same scans, the researchers aim to create a standard method for spotting these lesions, which could improve diagnosis and monitoring in clinics and future trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a reliable, standardized way to identify aggressive MS lesions on MRI, helping doctors predict disease course and guide treatment decisions.
What could go wrong
This is an observational study using existing scans, so it does not test a new treatment. The results depend on how well raters agree, and differences in MRI machines may still cause inconsistencies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS

Contacts and locations

Locations

  • Study site

    Oslo, 0372, Norway

  • Amsterdam UMC

    Amsterdam, 1105, Netherlands

  • Charles University and General University Hospital

    Prague, 128 00, Czechia

  • Danish Research Centre for Magnetic Resonance

    Copenhagen, 2650, Denmark

  • IRCCS San Raffaele

    Milan, 20132, Italy

  • Karolinska Neuroimmunology & Multiple Sclerosis (KNIMS) Centre

    Stockholm, 171 77, Sweden

  • Medical University Graz

    Graz, 8036, Austria

  • Medical University of Vienna

    Vienna, 1090, Austria

  • UCL Institute of Neurology

    London, WC1N 3BG, United Kingdom

  • University Hospital Basel

    Basel, 4031, Switzerland

  • University Hospital of Padua

    Padova, 35128, Italy

  • University Medical Center Mainz

    Homburg, 66424, Germany

  • University of Oxford

    Oxford, OX1 2JD, United Kingdom

  • University of Verona

    Verona, 37129, Italy

  • Vall d'Hebron University Hospital

    Barcelona, 08035, Spain

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