New MS drug copycat aims to match ocrevus in early trial

NCT ID NCT07597668

Ongoing Disease control Sponsor: R-Pharm Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This Phase 1 trial compares a new drug called RPH-035 to the approved MS drug Ocrevus. The study involves 180 adults with relapsing-remitting or secondary progressive multiple sclerosis who have flare-ups. Researchers are checking if RPH-035 behaves similarly in the body and has a comparable safety profile to Ocrevus.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ocrelizumab (RPH-035 and Ocrevus)
What this could lead to: If successful, this could show that RPH-035 is a safe and effective alternative to Ocrevus for managing multiple sclerosis.
What could go wrong: This is an early Phase 1 study focused on comparing drug levels and safety, not on proving effectiveness. It is small and may not lead to a new treatment option.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis relapsing-remitting multiple sclerosis secondary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS

Contacts and locations

Locations

Federal State Budgetary Educational Institution of Higher Education "Siberian State Medical University" of the Ministry of Health of the Russian Federation

Tomsk, 634050, Russia
Federal State Budgetary Healthcare Institution "Siberian District Medical Center of the Federal Medical and Biological Agency"

Novosibirsk, 630007, Russia
Federal State Budgetary Institution Federal Siberian Scientific and Clinical Center of the Federal Medical and Biological Agency

Krasnoyarsk, 660037, Russia
Federal State Budgetary Scientific Institution "Russian Center for Neurology and Neurosciences"

Moscow, 125367, Russia
Joint Stock Company "Medical and Sanitary Unit "Neftyanik"

Tyumen, 625048, Russia
Kazan State Medical Academy, branch of the Federal State Budgetary Educational Institution of Additional Professional Education Russian Medical Academy of Continuing Professional Education

Kazan', 420061, Russia
Kirov Regional State Clinical Budgetary Healthcare Institution "Center for Cardiology and Neurology"

Kirov, 610007, Russia
LLC "Center for Diagnostics and Rehabilitation "PRAKSIMED"

Saint Petersburg, 194223, Russia
Limited Liability Company DOCKBRAIN

Krasnodar, 350049, Russia
MEDIS Limited Liability Company

Nizhny Novgorod, 603137, Russia
Research Lab LLC

Moscow, 127521, Russia
Rostov Regional Clinical Hospital, State Budgetary Institution of the Rostov Region

Rostov-on-Don, 344015, Russia
Smolensk Regional Clinical Hospital, Regional State Budgetary Healthcare Institution

Smolensk, 214018, Russia
St. Petersburg State Budgetary Healthcare Institution "City Clinical Hospital No. 31"

Saint Petersburg, 197110, Russia
State Autonomous Healthcare Institution "Interregional Clinical and Diagnostic Center"

Kazan', 420101, Russia
State Autonomous Healthcare Institution Regional Clinical Hospital No. 3

Chelyabinsk, 454021, Russia
State Budgetary Healthcare Institution Leningrad Regional Clinical Hospital

Saint Petersburg, 194291, Russia
State Budgetary Healthcare Institution of the City of Moscow "City Clinical Hospital No. 24 of the Moscow Health Department"

Moscow, 127015, Russia
State Budgetary Healthcare Institution of the Nizhny Novgorod Region "Nizhny Novgorod Regional Clinical Hospital named after N. A. Semashko"

Nizhny Novgorod, 603126, Russia
State Budgetary Healthcare Institution of the Novosibirsk Region "State Novosibirsk Regional Clinical Hospital"

Novosibirsk, 630087, Russia
State Budgetary Healthcare Institution of the Perm Region "Perm Regional Clinical Hospital of the Order of the Badge of Honor"

Perm, 614045, Russia
State Budgetary Healthcare Institution of the Republic of Mordovia "Republican Clinical Hospital No. 4"

Saransk, 430032, Russia
Ulyanovsk Regional Clinical Hospital, a public health institution

Ulyanovsk, 432017, Russia

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