New imaging technique could reveal hidden brain inflammation

NCT ID NCT03807973

Terminated Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new imaging method to see if white blood cells enter the brain in people with multiple sclerosis, fibromyalgia, or chronic fatigue syndrome. Participants receive their own white blood cells tagged with a radioactive tracer, then undergo a brain PET/MRI scan. The goal is to better understand brain inflammation and improve future diagnosis and treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [Zr-89]oxine-labeled leukocytes (a radioactive tracer attached to the participant's own white blood cells)
What this could lead to: If successful, this imaging method could help doctors better understand and diagnose brain inflammation in conditions like multiple sclerosis, fibromyalgia, and chronic fatigue syndrome.
What could go wrong: This is a very early (Phase 1) study that is currently suspended, so results are uncertain. The imaging technique is experimental and may not prove useful for diagnosis or treatment.

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Conditions

The condition(s) this trial relates to.

fibromyalgia multiple sclerosis myalgic encephalomeyelitis/chronic fatigue syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC FATIGUE SYNDROME FIBROMYALGIA HEALTHY MULTIPLE SCLEROSIS

Contacts and locations

Locations

UAB

Birmingham, Alabama, 35294, United States

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