Brain scans reveal clues to MS fatigue
NCT ID NCT04144257
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study at Brigham and Women's Hospital used special PET scans to look at brain inflammation and chemical activity in 10 people with multiple sclerosis. The goal was to understand what causes the severe fatigue many MS patients experience. Researchers measured brain cell activity and chemical binding, then compared it to fatigue levels reported by participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PET radiopharmaceuticals ([F-18]PBR06 and [C-11]MRB)
- What this could lead to
- If successful, this could help explain why some people with MS feel severe fatigue, potentially pointing toward new treatments.
- What could go wrong
- This was a very small study (10 people) that only looked at brain images, not treatments. The findings may not apply to everyone with MS.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Brigham MS Center, 60 Fenwood Road
Boston, Massachusetts, 02115, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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