Bladder cocktail aims to stop recurrent UTIs in spinal cord injury

NCT ID NCT07643974

Not yet recruiting Disease control Sponsor: Medstar Health Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or spina bifida. 48 adults will receive six bladder washes over two weeks, with timing varied to see which schedule works best. The goal is to see if the probiotic can re-colonize the bladder and keep infections away for up to 28 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gentamicin and Lactobacillus rhamnosus GG (LGG) bladder washes
What this could lead to: If successful, this could point toward a way to reduce frequent urinary tract infections in people with neurogenic bladder, potentially lowering antibiotic use.
What could go wrong: This is a very early Phase 1 trial with only 48 participants, so results may not apply broadly. The approach involves bladder washes, which may be uncomfortable or cause irritation.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis spina bifida spinal cord disorder spinal cord injury Urinary Bladder, Neurogenic urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS NEUROGENIC BLADDER (NB) NEUROGENIC LOWER URINARY TRACT DYSFUNCTION SPINA BIFIDA SPINAL CORD INJURY URINARY TRACT INFECTION(UTI)

Contacts and locations

Locations

MedStar National Rehabilitation Hospital

Washington D.C., District of Columbia, 20010, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15224, United States

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