SPINA BIFIDA

This study tests whether giving the drug oxybutynin directly into the bladder can help children with spina bifida who have bladder problems. The goal is to increase bladder capacity and reduce the need for more invasive treatments like Botox injections or surgery. About 60 childr…

This study tests a new way to repair open spine defects (spina bifida) in newborns. Doctors will use a patch made from the baby's own umbilical cord to cover the opening in the spine. The goal is to see if this helps the wound heal better, reduces fluid leaks, and improves long-t…

This study tests whether a mobile health system can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury improve their wellness and self-management skills. About 160 participants aged 12 and older will use the system…

This study tests a treatment called transcutaneous tibial nerve stimulation (TTNS) for children with spina bifida who leak urine despite using catheters. TTNS uses mild electrical pulses at the ankle to stimulate a nerve that helps control the bladder. Twelve children aged 8-18 w…

This study tests a 10-week online group program for adults with spina bifida to improve self-esteem, quality of life, and reduce anxiety and depression. Participants attend weekly 1.5-hour video sessions with 6-7 others, plus two follow-ups. The goal is to strengthen social skill…

This study compares two ways of making ankle-foot braces (AFOs) for people with leg weakness from conditions like cerebral palsy, stroke, or spinal cord injury. The traditional method uses a plaster cast, while the newer method uses 3D scanning and printing. Researchers want to s…

This study tests a robotic leg brace (exoskeleton) designed to improve walking in children aged 3 to 17 with conditions like cerebral palsy, spina bifida, muscular dystrophy, or incomplete spinal cord injury. The device can assist or resist leg movement during walking. The trial …

This study looks at two types of enema programs to see which helps children and adults with spina bifida control their bowel movements better. Participants will fill out online surveys three times over a year. The goal is to find out which method prevents accidents, improves inde…

This study looks at a special clinic designed to help adults with conditions like cerebral palsy, spina bifida, or developmental disabilities get better, ongoing care. Many of these people face a "cliff" when they leave children's healthcare and struggle to find adult doctors who…

This study uses mild electrical stimulation on the skin over the spine to measure how nerves and muscles work in children with spina bifida. Researchers will test muscle strength, spasticity, walking, and coordination in 30 participants. The goal is to better understand sensorimo…

This study looks at whether two substances in urine (TIMP-2 and MMP-2) can predict kidney damage in people with spina bifida. Researchers will compare these biomarkers with standard tests that measure bladder and kidney function. If successful, it could lead to a simpler, non-inv…