MS patients may soon swap IV drips for quick shots

NCT ID NCT07325292

Recruiting now Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This Phase 3 trial tests whether a simple injection of frexalimab every 4 weeks works as well as the standard IV infusion for adults with relapsing or non-active progressive multiple sclerosis. About 160 participants will be randomly assigned to one of the two methods. The study lasts 48 weeks and aims to see if the injection provides similar drug levels and safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: frexalimab
What this could lead to: If successful, this could show that a simple injection works as well as an IV infusion for controlling multiple sclerosis, making treatment more convenient.
What could go wrong: This is an early-stage Phase 3 trial with only 160 participants, so results may not apply to everyone. The study compares two ways of giving the same drug, not against a placebo, so it won't prove the drug itself works.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis relapsing-remitting multiple sclerosis secondary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

ANESC Research- Site Number : 8400187
RECRUITING

El Paso, Texas, 79912, United States
Advanced Neurology of Colorado- Site Number : 8400148
RECRUITING

Fort Collins, Colorado, 80528, United States
Alabama Neurology Associates- Site Number : 8400115
RECRUITING

Homewood, Alabama, 35209, United States
Aqualane Clinical Research- Site Number : 8400026
RECRUITING

Naples, Florida, 34105, United States
Azienda Ospedaliera San Camillo Forlanini Site Number : 3800001
RECRUITING

Roma, 00152, Italy
Azienda Ospedaliero-Universitaria Ospedali Riuniti di Foggia Site Number : 3800019
RECRUITING

Foggia, 71122, Italy
Center for Neurology and Spine - Phoenix - East Bell Road- Site Number : 8400195
RECRUITING

Phoenix, Arizona, 85032, United States
Consultants in Neurology- Site Number : 8400020
RECRUITING

Northbrook, Illinois, 60062, United States
Fondazione Policlinico Universitario Campus Bio-Medico Site Number : 3800038
RECRUITING

Roma, 00128, Italy
Holy Name Medical Center- Site Number : 8400101
RECRUITING

Teaneck, New Jersey, 07666, United States
Hope Neurology- Site Number : 8400019
RECRUITING

Knoxville, Tennessee, 37922, United States
Investigational Site Number : 0560001
RECRUITING

Bruges, 8000, Belgium
Investigational Site Number : 0560005
RECRUITING

Overpelt, 3900, Belgium
Investigational Site Number : 0560006
RECRUITING

Ghent, 9000, Belgium
Investigational Site Number : 0560007
RECRUITING

Kortrijk, 8500, Belgium
Investigational Site Number : 0560008
RECRUITING

Brussels, 1200, Belgium
Investigational Site Number : 1560004
RECRUITING

Chengdu, 610041, China
Investigational Site Number : 1560005
RECRUITING

Beijing, 100034, China
Investigational Site Number : 1560010
RECRUITING

Jiazhuang, 050000, China
Investigational Site Number : 1561029
RECRUITING

Chengdu, 610072, China
Investigational Site Number : 3800016
RECRUITING

Milan, Milano, 20133, Italy
Investigational Site Number : 3920001
RECRUITING

Kyoto, 616-8255, Japan
Investigational Site Number : 3920008
RECRUITING

Yahaba, Iwate, 028-3695, Japan
Investigational Site Number : 3920017
RECRUITING

Sapporo, Hokkaido, 063-0005, Japan
Joi Life Wellness Group LLC- Site Number : 8400192
RECRUITING

Smyrna, Georgia, 30080, United States
Michigan Institute for Neurological Disorders- Site Number : 8400004
RECRUITING

Farmington Hills, Michigan, 48334, United States
Neurology Associates of Ormond Beach- Site Number : 8400086
RECRUITING

Ormond Beach, Florida, 32174, United States
Neurology of Central Florida- Site Number : 8400147
RECRUITING

Altamonte Springs, Florida, 32714, United States
North Central Neurology Associates- Site Number : 8401100
RECRUITING

Cullman, Alabama, 35058, United States
North Texas Institute of Neurology & Headache - Plano- Site Number : 8400082
RECRUITING

Plano, Texas, 75024, United States
North Texas Institute of Neurology & Headache - Plano- Site Number : 8400083
RECRUITING

Plano, Texas, 75024, United States
Palm Beach Neurology- Site Number : 8400105
RECRUITING

West Palm Beach, Florida, 33407, United States
Perseverance Research Center- Site Number : 8400138
RECRUITING

Scottsdale, Arizona, 85253, United States
Piedmont HealthCare - Lake Norman Neurology- Site Number : 8400002
RECRUITING

Charlotte, North Carolina, 28210, United States
Private Practice - Dr. Regina Berkovich- Site Number : 8400005
RECRUITING

West Hollywood, California, 90048, United States
Raleigh Neurology Associates- Site Number : 8400014
RECRUITING

Raleigh, North Carolina, 27607, United States
The Boster Center for Multiple Sclerosis- Site Number : 8400006
RECRUITING

Columbus, Ohio, 43235, United States
The Ohio State University- Site Number : 8400009
RECRUITING

Columbus, Ohio, 43210, United States

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