MS patients may soon get a simpler shot option

NCT ID NCT07609719

First seen May 29, 2026

Summary

This study looks at whether people with multiple sclerosis can safely switch from their current anti-CD20 therapy to a new under-the-skin version of ocrelizumab. About 100 participants will be followed for up to 48 weeks to see if brain lesions stay stable and if they are satisfied with the treatment. The goal is to offer a more convenient option for managing the disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Advanced Neurology of Colorado

    Fort Collins, Colorado, 80528, United States

  • Alabama Neurology Associates

    Birmingham, Alabama, 35209, United States

  • Caribbean Center for Clinical Research

    Guaynabo, 00968, Puerto Rico

  • Clinical Endpoints

    Scottsdale, Arizona, 85258, United States

  • DHR Health MS Center

    McAllen, Texas, 78501, United States

  • Minneapolis Clinic of Neurology

    Minneapolis, Minnesota, 55422, United States

  • MultiCare Institute for Research & Innovation

    Tacoma, Washington, 98405, United States

  • Multiple Sclerosis Center of Atlanta/Atlanta Neuroscience Institute

    Atlanta, Georgia, 30327, United States

  • Neurology Associates - Maitland

    Orlando, Florida, 32751, United States

  • Neurology Clinic, P.C.

    Cordova, Tennessee, 38018, United States

  • Ohio State University, Multiple Sclerosis and Neuroimmunology Center

    Columbus, Ohio, 43210, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ocrelizumab combined with recombinant human hyaluronidase (rHuPH20) given as a shot under the skin

What this could lead to

If it works, this could offer a more convenient way to control multiple sclerosis with fewer clinic visits.

What could go wrong

This is a small, early-phase study with no placebo group, so results may not apply broadly. Switching therapies could also cause unexpected side effects.

Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.