Can early MS patients pause treatment? new trial seeks answers
NCT ID NCT05285891
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether people with early relapsing multiple sclerosis (MS) can stop taking ocrelizumab (Ocrevus) after two years without their disease coming back. All 123 participants will receive ocrelizumab for the first two years. Then, some will switch to a placebo while others continue the drug. Researchers will track relapses and brain scans for another two years to see if stopping is safe and effective.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ocrelizumab (Ocrevus)
What this could lead to
If successful, this could show that some early MS patients may be able to stop treatment without relapse, reducing long-term drug exposure and side effects.
What could go wrong
This is a Phase 4 trial with only 123 participants, so results may not apply to all MS patients. There is a risk of relapse or new brain lesions if treatment is stopped.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10007, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MedStar Georgetown University Hospital
RECRUITINGWashington D.C., District of Columbia, 20007, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oklahoma Medical Research Foundation
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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RWJ Barnabas Health
RECRUITINGLivingston, New Jersey, 07039, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The University of Texas Health Science Center at Houston, McGovern Medical School
RECRUITINGHouston, Texas, 77030, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Massachusetts Memorial Medical Center
RECRUITINGWorcester, Massachusetts, 01655, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pennsylvania, Perelman School of Medicine
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Contact Email: •••••@•••••
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University of Rochester Medical Center
RECRUITINGRochester, New York, 14627, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Commonwealth University School of Medicine
RECRUITINGRichmond, Virginia, 23298, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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Yale School of Medicine
RECRUITINGNew Haven, Connecticut, 06510, United States
Contact
Contact Email: •••••@•••••