Orange you curious? citrus pill tested for MS fatigue

NCT ID NCT07452562

Recruiting now Symptom relief Sponsor: Swansea University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a daily 500 mg hesperidin supplement (found in citrus fruits) can reduce fatigue, improve mood, and sharpen thinking in people with multiple sclerosis. Sixty adults with MS will take either hesperidin or a placebo for 12 weeks. The main focus is on fatigue, with additional checks on stress and mental performance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hesperidin (a citrus fruit supplement)
What this could lead to: If it works, this could point toward a simple dietary supplement to help manage fatigue and mood in multiple sclerosis.
What could go wrong: This is a small early-stage trial with only 60 people, so results may not apply widely. Supplements often show limited benefits in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS

Contacts and locations

Locations

FHMLS, Nutrition Lab
RECRUITING

Swansea, Wales, SA2 8PP, United Kingdom

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