Fondation Ophtalmologique Adolphe De Rothschild

This early-stage study tests whether it is safe to combine a drug called etanercept with repeated ultrasound sessions to temporarily open the blood-brain barrier in people with mild Alzheimer's disease. The goal is to let more of the drug reach the brain to reduce inflammation. O…

This study tests whether giving dornase alfa (a drug already used for cystic fibrosis) daily for up to 14 days after a brain bleed from a ruptured aneurysm can help people recover better. The goal is to see if more patients can live independently at 6 months. The trial will enrol…

This study tests whether adding a fast-acting blood thinner (cangrelor) to standard clot removal improves recovery in people with a severe stroke. About 368 adults with a large artery blockage in the brain will receive either cangrelor plus the procedure or the procedure alone. T…

This study tests whether the drug bevacizumab, given through a vein, can improve symptoms like headaches, seizures, and thinking problems in people with brain arteriovenous malformations (AVMs) that are too large or risky for surgery or radiation. About 54 adults with moderate to…

This phase 3 trial tests whether people with active multiple sclerosis who have been stable on Ocrevus for at least two years can safely switch to annual infusions instead of the standard every-6-month schedule. The goal is to see if the less frequent dosing is just as good at pr…

This study tests whether starting steroids right away, and adding rituximab if symptoms return, can prevent eye muscle weakness from spreading to other muscles in people with ocular myasthenia gravis. About 128 adults with recent diagnosis will be followed for 2 years. The goal i…

This study compares two invasive procedures—venous sinus stenting and a neurosurgical shunt—for treating idiopathic intracranial hypertension, a condition that causes high pressure in the brain and can lead to vision loss. The trial will enroll 276 adults who have not improved wi…

This study looks at how safe and effective DMEK (a type of cornea transplant) is for people who have already had eye surgeries like vitrectomy or glaucoma surgery. Researchers will track serious complications and vision improvement over 12 months in 80 participants. The goal is t…

This study is testing a new, 10-minute MRI sequence (3D FGAPSIR) to see if it can find more spinal cord lesions in people with multiple sclerosis than standard scans. Researchers will enroll 200 adults already scheduled for a spinal MRI. The goal is to improve detection of spinal…

This study is testing whether a special MRI sequence called MP2RAGE can find more spinal cord lesions in people with multiple sclerosis than the standard scans currently used. Researchers will compare the number of lesions seen on MP2RAGE images versus conventional MRI in 196 adu…

This study looks at whether lower-resolution MRI scans can still reliably detect giant cell arteritis, a serious inflammation of arteries that can cause blindness or stroke. Researchers will compare different MRI techniques in 133 adults suspected of having the disease. If lower-…

This study tests whether an extra 8-minute MRI scan can better detect anterior ischemic optic neuropathy (AION), a type of eye stroke. Researchers will enroll 250 adults with suspected AION and compare the new scan to standard MRI. The goal is to see if the new method is more sen…

This study tests a new way to screen for abdominal aortic aneurysm (AAA), a dangerous bulge in the main belly artery that can be fatal if it bursts. Currently, patients must visit a radiologist for an ultrasound, but many don't go. Researchers are training general practitioners (…

This study compares having cataract surgery on both eyes the same day versus waiting weeks between surgeries. Researchers want to see if same-day surgery is just as safe, costs less, and improves quality of life. About 242 adults in France with cataracts in both eyes will take pa…

This study aims to find genetic mutations in the brain that cause drug-resistant epilepsy in children. Researchers will compare DNA from blood and brain tissue, including samples from special electrodes placed in the brain. The goal is to better understand the root causes of thes…

This pilot study aims to see if a special MRI sequence can detect lymphatic damage in people with brain vein narrowing or clots. About 100 adults will get an extra MRI scan during their regular care. No new treatment is tested; the goal is to learn if this MRI method can spot lym…

This study looks at how the immune system and blood clotting change in the first day after a stroke treated with a clot-removal procedure called thrombectomy. Researchers will collect blood samples from 1,200 participants to find markers that might predict how well people recover…

This study looks at brain tissue and MRI scans from 15 people who had a severe stroke and needed surgery. Researchers want to understand if certain dark spots on MRI are caused by tiny blood clots or bleeding. The goal is to learn more about what happens in the brain after a stro…

This study looks at blood clots removed from stroke patients during a procedure called thrombectomy. Researchers will also take a small blood sample. They want to see if the clot's makeup and blood markers can tell us more about what caused the stroke, how well treatment worked, …

This study follows 2,000 adults who have had a brain aneurysm sealed with a coil or similar procedure. The goal is to track how often the aneurysm reopens over time and whether another treatment is needed. By collecting standardized data, researchers hope to improve follow-up car…

This study follows 1000 adults who have had embolization for brain arteriovenous malformations (AVMs). The goal is to collect standardized long-term data, such as how well the AVM remains blocked over time. Currently, follow-up practices vary widely, so this research aims to impr…

This study looks at the genes of 300 people with brain or spinal cord arteriovenous malformations (AVMs) to see if certain mutations affect the risk of bleeding. Researchers will compare genetic information with medical outcomes to better understand why some AVMs cause serious pr…

This study looks at blood markers related to inflammation and clotting in people with brain oxygen deprivation from stroke or bleeding. Researchers will compare these markers between patients with brain hypoxia and those without. The goal is to see if these markers are linked to …

This study is collecting data from 5,000 people who had a stroke caused by a blood clot and received endovascular treatment (a procedure to remove the clot). The goal is to measure how well patients recover neurologically three months later. This information is rarely collected b…

This study aims to find biological markers in the blood that can help measure whether a potential ALS therapy is working. Researchers will collect tiny particles shed by brain cells from 30 ALS patients and 30 healthy volunteers. By comparing these particles, they hope to identif…

This study tests whether ultra-high-resolution MRI can more clearly identify a rare, benign brain tumor called MVNT. Currently, standard MRI may leave the diagnosis uncertain, leading some patients to undergo surgery for a harmless growth. Researchers will scan 33 adults with sus…

This study looks at how the brain learns to control sound by having patients play a theremin-like instrument during awake brain surgery. Researchers will record brain activity directly from the surface of the brain to understand sensorimotor learning. The study involves 50 people…

This study looks at how seizures change the brain's wiring in children with drug-resistant focal epilepsy. Researchers will use special EEG recordings and MRI scans to measure brain connections in 82 children. The goal is to understand if ongoing seizure activity causes lasting d…

This study is testing whether a special type of MRI scan can predict how children with retinoblastoma, a rare eye cancer, will respond to chemotherapy delivered directly to the eye. Researchers will scan 60 children before treatment and check if the scan results match their respo…

This study looks at why people with long-term nerve pain often feel less motivated. Researchers will use brain scans (fMRI) and a reward-learning task to compare 50 chronic pain patients with healthy volunteers. The goal is to understand brain changes linked to motivation, not to…

This study aims to improve MRI scans by testing different sequence settings to get clearer images and make the exam more comfortable. Researchers will compare the standard MRI sequence with several new variants in 750 adults, including patients and healthy volunteers. The goal is…

This study is testing whether a type of MRI scan, called resting-state functional MRI, can predict if epilepsy surgery will be successful in children aged 6 to 18. The scan measures how different parts of the brain communicate while at rest. Researchers hope this will help doctor…

This study aims to understand how children's brains learn to combine words into meaningful sentences. Researchers will record brain activity from 100 children (ages 2-20) who already have electrodes implanted in their brains for epilepsy monitoring. While listening to stories lik…

This study is testing whether a special type of MRI, called resting-state fMRI, can predict how well people with optic neuritis (inflammation of the optic nerve) will recover their vision. Researchers will scan 200 patients and track their vision over 6 months. The goal is to see…

This study uses MRI scans to look at how the brain's visual networks change in people with inherited retinal diseases. Researchers will scan 200 patients before and after they receive treatments like retinal implants or optogenetics. The goal is to understand how the brain adapts…

This study compares two ways to take pictures of the eye without touching it: ultrasound and MRI. About 30 adults will get both tests to see how well the results match. The goal is to understand when each method works best, not to treat any disease.

This study looks at whether platelets—small blood cells that help with clotting—are found inside brain and spinal cord tumors. Researchers want to see if the presence of platelets in these tumors is linked to how long patients survive. The study will involve 50 adults who are hav…

This study tests whether adding high-resolution sequences to a standard MRI can more accurately show the position of a parotid tumor relative to the facial nerve. About 88 adults scheduled for first-time parotid tumor surgery will receive the enhanced MRI before their operation. …

This study looks at copper levels in breast milk from women with Wilson's disease who are on treatment. Wilson's disease causes copper buildup, and treatment can lower copper, which might affect breast milk. The goal is to find out if breastfeeding is safe for their babies. About…

This study looks at dental health and oral quality of life in people with Wilson's disease, comparing those with liver versus neurological symptoms to healthy controls. Researchers will collect saliva samples and use questionnaires and dental exams to see if copper levels in sali…

This study looks at whether Wilson's disease, a condition where copper builds up in the body, also damages the heart. Researchers will monitor 150 adults with Wilson's disease using heart scans, blood tests, and long-term heart rhythm recorders. The goal is to find out how often …

This study explores whether a driving simulator combined with an EEG (brain wave monitor) can better assess driving ability in people with epilepsy. Researchers will measure attention, speed, and braking in 40 licensed drivers with epilepsy. The goal is to improve how doctors dec…

This study is testing whether people with epilepsy release specific odors that can predict a seizure before it happens. Researchers will collect skin swabs from 100 adults with drug-resistant epilepsy during and between seizures. The goal is to identify the chemical 'signature' o…

This study aims to create a database of eye images using a new holographic Doppler laser device. The goal is to better visualize and measure blood flow in the retina and choroid, which is important for diagnosing eye diseases. About 123 adults, both with and without eye condition…

This study looks at whether sinusitis (sinus infection) is common in people with wet age-related macular degeneration (AMD) who need many eye injections. Researchers will screen 200 participants for sinusitis and treat it if found. They will then check if sinusitis treatment redu…

This study surveys 400 adults with epilepsy in France to understand why they are less physically active than the general population. Researchers will look at how fear, stigma, and personal beliefs affect exercise habits. The goal is to find ways to help people with epilepsy be mo…

This study looks at whether damage to the glycocalyx, a protective lining inside blood vessels, is linked to glaucoma. Researchers will compare 50 people with glaucoma to 50 without, using a non-invasive device to measure this lining under the tongue. The goal is to see if blood …

This study is looking at tiny changes on the surface of eye cells in people with severe dry eye. Researchers will compare these cells before and after treatment starts, and also compare them to people without dry eye. The goal is to better understand what happens in the disease, …

This study looks at two treatments made from patients' own blood—autologous serum and growth factor-rich plasma—to see which helps heal the cornea better in people with aniridia, a rare eye condition. Researchers will test these treatments on corneal cells in the lab, using blood…

This study follows 1,000 myopic children in Europe for 5 years, measuring their eye growth every 6 months. The goal is to understand how nearsightedness progresses in this population, since most research has been done in Asia. Participants will have regular eye exams, including a…

This study is looking at 60 people with a genetic eye surface disease called limbal stem cell deficiency. Researchers want to find out if certain gene changes are linked to more severe disease. They will compare patients' genes with their eye health to look for patterns. This is …

This study is testing a new virtual reality (VR) test called VisionumVR to see if it can reliably measure how well people with low vision improve during rehabilitation. About 60 participants who are starting or already in orthoptic low vision therapy will take a 20-minute VR task…

This study is testing whether special eye scans can detect changes linked to memory disorders like Alzheimer's and Parkinson's. Researchers will compare eye images from 450 people with and without memory complaints. The goal is to see if these non-invasive scans can help diagnose…