Fondation Ophtalmologique Adolphe De Rothschild

This study compares two procedures for adults with idiopathic intracranial hypertension, a condition where high pressure in the skull threatens vision after standard medication fails. Researchers will test whether placing a stent in a narrowed brain vein or surgically inserting a…

This study aims to understand how safe and effective a specific type of corneal transplant (DMEK) is for patients who have had previous eye surgeries. It will follow 80 patients for 12 months to track serious complications and measure improvements in their vision. The goal is to …

This study is testing if a drug called bevacizumab, given through an IV, can help improve symptoms like headaches, seizures, thinking problems, or weakness in adults with complex brain arteriovenous malformations (AVMs). It is for people whose AVMs cause significant symptoms and …

This study is testing whether people with multiple sclerosis who have been stable on treatment for 2 years can safely switch from getting infusions every 6 months to once a year. Researchers want to see if the less frequent schedule still prevents new brain lesions while potentia…

This study tests if starting strong anti-inflammatory drugs (corticosteroids) right after diagnosis, and adding a targeted immune drug (rituximab) if needed, can prevent eye muscle weakness from spreading to other muscles in people with ocular myasthenia gravis. It will compare t…

This study compares two ways to perform cataract surgery when both eyes need it. It tests if operating on both eyes the same day is as safe and effective as the standard method of doing them weeks apart, while also looking at costs and patient quality of life. The goal is to see …

This study is testing if adding an intravenous antiplatelet drug (cangrelor) to the standard mechanical clot removal procedure helps people recover better after a major stroke. It will involve about 368 adults who have had a stroke within the last 24 hours and are eligible for th…

This study aims to see if a special type of MRI scan can predict how well children with retinoblastoma (a childhood eye cancer) will respond to a targeted chemotherapy treatment. Researchers will scan 60 children before they start treatment to look for signs that might show if th…

This study is testing a new type of MRI scan sequence to see if it can better find and describe injuries in the spinal cord of people with multiple sclerosis (MS). Researchers will compare the new scan to standard scans in 200 adult participants. The goal is to improve detection …

This study is testing whether a newer type of MRI scan, called MP2RAGE, can find more spinal cord lesions in people with multiple sclerosis than the standard set of MRI scans currently used. Researchers will compare images from both methods in about 196 adult patients who are alr…

This study aims to see if lower-quality MRI scans can still accurately diagnose giant cell arteritis, a serious inflammatory condition affecting arteries in the head. Researchers will compare different MRI scan resolutions in 133 adults suspected of having the disease. The goal i…

This study tests whether training family doctors to use portable ultrasound machines during regular visits can help more at-risk people get screened for dangerous abdominal aortic bulges. Currently, patients must be referred to specialists for this screening, which many don't com…

This study aims to compare two different scanning methods—MRI and ultrasound—to see how well they measure the layers of the eye. Researchers will enroll 30 adults who are already scheduled for a diagnostic eye ultrasound. The goal is to understand when these two tests agree or di…

This study is testing whether a special, high-resolution MRI scan can help surgeons better plan operations to remove parotid gland tumors. The scan aims to create a detailed map showing the tumor's exact position relative to the important facial nerve. Researchers will compare th…

This study is testing whether a special type of brain scan, called a resting-state functional MRI, can help predict if surgery will successfully control seizures in children with drug-resistant epilepsy. Researchers will analyze brain network patterns from the scans of 200 childr…

This study aims to improve the diagnosis of a rare, non-cancerous brain tumor called MVNT using more detailed MRI scans. Researchers will test advanced imaging techniques on 33 adult patients who show signs of this tumor on their initial scans. The goal is to create clearer diagn…

This study is testing whether adding a special 8-minute MRI scan to a standard eye exam can better detect a condition called anterior ischemic optic neuropathy (a type of 'eye stroke'). Researchers will enroll 250 adults who are already scheduled for an eye MRI because a doctor s…

This study aims to find better ways to assess if people with epilepsy can drive safely. Researchers will use a driving simulator and brain activity tests to measure attention and driving skills in 40 participants with epilepsy. The goal is to gather information that could help do…

This study aims to collect long-term health data from 2000 people who have had a brain aneurysm treated with a procedure called embolization. The goal is to create a standard schedule for follow-up scans and check-ups to better understand when the aneurysm might reopen and requir…

This study aims to understand if platelets, tiny blood cells, are present inside brain tumors and if their presence is linked to how long patients live. Researchers will collect and analyze tumor tissue and blood samples from 50 adults undergoing surgery for brain or spinal cord …

This study aims to see if a special type of MRI brain scan, taken while a person is resting, can predict how well someone's vision will recover after an episode of optic neuritis. Researchers will compare brain scans from 200 adults with suspected optic neuritis to scans from a c…

This study aims to understand how children's brains learn and process language as they grow. Researchers will record brain activity from 100 children (ages 2-20) with epilepsy who already have electrodes implanted for medical monitoring. While listening to stories and sentences, …

This study aims to understand if there is a connection between sinus infections and a severe form of age-related macular degeneration (AMD), a leading cause of vision loss. Researchers will check 200 patients with wet AMD for sinusitis. They want to see if treating the sinus infe…

This study aims to understand how the body's immune system reacts in the first day after a stroke is treated with a clot-removal procedure. Researchers will track 1200 patients to see if specific immune system patterns can predict recovery at 3 and 12 months. The goal is to gathe…

This study aims to understand why some stroke patients don't recover well even after successful clot removal. Researchers will compare special MRI brain scans with actual brain tissue samples from 15 patients who need major surgery after a severe stroke. The goal is to see if tin…

This study aims to understand how Wilson's disease affects oral health. Researchers will compare the dental health of 150 people with the disease to healthy volunteers, checking for cavities and gum problems. They will also test if copper levels in saliva can show how well the di…

This study aims to better understand severe dry eye by looking closely at specific markers on the surface of eye cells. Researchers will compare these markers in 100 people with severe dry eye to those without the condition, and see how they change after starting treatment. The g…

This study aims to collect and standardize information on how well patients recover three months after having a procedure to remove a blood clot from the brain during a stroke. It will follow 5,000 people who have had this endovascular treatment. The goal is to better understand …

This study aims to understand the connection between a person's genes and the severity of a rare eye disease that affects the surface of the eye. Researchers will study 60 people who have a genetic condition affecting their eye surface to see which genetic changes are linked to t…

This study aims to understand if damage to a protective lining inside tiny blood vessels is linked to glaucoma, a common eye disease that can lead to vision loss. Researchers will compare 100 people with glaucoma to people without it, using a special camera to take pictures of th…

This study aims to test a new type of MRI scan to see if it can detect changes in lymph nodes near the brain in people who have blockages in their brain veins. It will enroll 100 adults who are already scheduled for a contrast MRI as part of their standard care for conditions lik…

This study is a laboratory experiment comparing two treatments made from a patient's own blood to see which one might work better for healing the cornea (the clear front part of the eye) in people with aniridia, a rare eye condition. Researchers will take blood samples from 24 pe…

This study aims to understand how chronic nerve pain affects the brain's reward system and motivation. Researchers will compare brain scans and learning tasks in 50 people with chronic pain against healthy volunteers. The goal is to learn why pain can reduce motivation, not to te…

This study aims to understand how certain substances in the blood relate to brain injury from strokes or bleeding. Researchers will compare blood samples from 200 patients who have had a major stroke or brain bleed with those who had a minor, temporary event. The goal is to see i…

This study is testing if new, non-invasive eye imaging techniques can find unique signs in the retina linked to Alzheimer's disease and other memory disorders. Researchers will compare detailed scans of the eye's blood vessels and structure in 450 people with memory complaints ag…

This study aims to understand how the human brain learns complex motor-sensory skills, like playing a musical instrument. Researchers will record brain activity from 50 patients who are already undergoing awake brain surgery for epilepsy or a brain tumor. During surgery, patients…

This study aims to find the best settings for MRI scans to improve image quality and make the experience more comfortable for patients. It involves 750 adults who will have an MRI scan using both the standard method and new test versions. Researchers will compare the images to se…

This study aims to collect long-term follow-up data from 1,000 adults who have undergone a procedure called embolization to treat abnormal tangles of blood vessels in the brain (arteriovenous malformations or AVMs). Because there is no standard way to track patients after this tr…

This study aims to identify specific odors people release before an epileptic seizure. Researchers will collect air samples from 100 adults with drug-resistant epilepsy during their hospital stay. The goal is to find a chemical 'signature' that could one day lead to a non-invasiv…

This study aims to understand how seizures affect brain connections in children with drug-resistant epilepsy. Researchers will use advanced brain imaging and recordings from implanted electrodes to measure how seizure activity changes the brain's wiring patterns. The study includ…

This study aims to create a database of images and videos showing blood flow in the back of the eye using a new type of laser device. It will enroll 123 adults, including people with various eye conditions and some with healthy eyes. The goal is to test if the device can clearly …

This study aims to learn more about strokes by analyzing the blood clots that cause them. Researchers will collect clots removed from 1,200 stroke patients and compare them to blood samples and patient health records. The goal is to see if the clot's makeup can help explain why t…

This study aims to measure copper levels in the breast milk of mothers who have Wilson's disease and are receiving treatment. Researchers want to understand if current treatments affect copper content in breast milk, which could impact infant nutrition. The goal is to gather data…

This study aims to understand how inherited retinal diseases, which cause vision loss, affect the brain's visual networks. Researchers will use MRI scans to map brain activity in 200 adult patients before and after they receive new artificial vision treatments, like retinal impla…

This study aims to find biological markers in the blood that could indicate the presence of ALS. Researchers will compare blood samples from 30 people with ALS and 30 healthy volunteers, looking for differences in tiny particles released by nerve cells. The goal is to find tools …

This study aims to understand why some children's epilepsy does not respond to medication. Researchers will analyze genetic material from brain tissue and blood samples of 450 children with drug-resistant focal epilepsy. The goal is to identify specific genetic changes in the bra…

This study is a survey aiming to understand why adults with epilepsy are often less physically active than others. It will enroll 400 participants to explore how factors like fear of seizures, stigma, and personal identity affect exercise habits. The goal is to gather knowledge t…

This study aims to understand how the eyes of nearsighted children grow over time. Researchers will follow 1,000 myopic children in Europe, taking detailed eye measurements and images. The goal is to learn more about the natural progression of myopia and why it differs from child…

This study aims to understand how genetic changes are linked to the development and outcomes of arteriovenous malformations (AVMs) in the brain and spinal cord. Researchers will analyze genetic material from 300 patients with diagnosed AVMs to see if specific gene mutations corre…

This study aims to understand if and how Wilson's disease affects the heart in adults. Researchers will perform detailed heart scans and tests on 150 adult patients to look for damage caused by copper buildup. The goal is to gather better information to guide future heart screeni…

This study is testing a new virtual reality (VR) tool to see if it can reliably measure how well people with low vision are improving during their rehabilitation therapy. Researchers will have 60 participants with visual impairment use a VR headset to perform a 20-minute task tha…