Could a 'Hibernation Cocktail' protect the brain after a stroke?
NCT ID NCT07364344
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tests whether a combination of two drugs (chlorpromazine and promethazine) can safely put stroke patients into a hibernation-like state to protect the brain. The trial will enroll 57 adults with acute ischemic stroke who are eligible for clot-removal therapy. Researchers will first find the safest dose, then check if it reduces brain damage and improves symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Chlorpromazine and Promethazine (drug combination)
What this could lead to
If safe and effective, this approach could reduce brain damage and improve recovery after a stroke.
What could go wrong
This is a very early, small Phase I safety study with only 57 people. The drugs may not work as hoped or could cause serious side effects like low blood pressure or sedation.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- THUNDER Stroke Study: Penumbra System with Thund NCT05437055
- Stroke Alarm Efficacy Trial (NCT06315192)
- IMPROVE-II: FAST Model for Stroke Reperfusion (NCT06330051)
- Virtual Reality Rehab for Stroke Recovery - NCT07674329
- Endovascular Therapy for Basilar Artery Stroke (NCT07672795)
- Oropharyngeal Suction Tube for Stroke Pneumonia NCT07647666
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••