Could a 'Hibernation Cocktail' protect the brain after a stroke?
NCT ID NCT07364344
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tests whether a combination of two drugs (chlorpromazine and promethazine) can safely put stroke patients into a hibernation-like state to protect the brain. The trial will enroll 57 adults with acute ischemic stroke who are eligible for clot-removal therapy. Researchers will first find the safest dose, then check if it reduces brain damage and improves symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Chlorpromazine and Promethazine (drug combination)
- What this could lead to
- If safe and effective, this approach could reduce brain damage and improve recovery after a stroke.
- What could go wrong
- This is a very early, small Phase I safety study with only 57 people. The drugs may not work as hoped or could cause serious side effects like low blood pressure or sedation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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