Could two blood thinners be better than one for stroke prevention?
NCT ID NCT07237308
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares apixaban alone versus apixaban plus clopidogrel for 30 days in people who have had a stroke and have both atrial fibrillation and atherosclerosis. About 586 participants will be randomly assigned to one of the two treatments. The goal is to see if the combination reduces new brain lesions on MRI scans better than apixaban alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Apixaban (Eliquis) and clopidogrel (Plavix)
- What this could lead to
- If successful, this could show that a short course of dual therapy reduces the risk of another stroke in high-risk patients.
- What could go wrong
- This is a phase 4 trial with 586 participants, so results may not apply to everyone. Adding clopidogrel also raises bleeding risk.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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