Can breathing pure oxygen boost stroke recovery?
NCT ID NCT05965687
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This trial investigates whether breathing high-dose oxygen (normobaric hyperoxia) for four hours, given together with standard clot-busting medication, can improve recovery in people having an acute ischemic stroke. The study enrolls adults who arrive at the hospital within 4.5 hours of symptom onset with moderate to severe stroke symptoms. Participants are randomly assigned to receive either high-dose oxygen or standard nasal oxygen alongside their clot-busting treatment, and researchers track functional outcomes and brain damage over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- normobaric hyperoxia (high-dose oxygen given through a sealed mask for 4 hours)
- What this could lead to
- If it works, this could offer a simple, widely available way to boost the effectiveness of standard clot-busting treatment for stroke.
- What could go wrong
- This is a large phase 3 trial, but high-dose oxygen can sometimes cause lung irritation or other side effects. It is not yet known whether the added oxygen improves outcomes enough to justify routine use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Xuan Wu Hospital，Capital Medical University
Beijing, China
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Other studies related to the condition(s) this trial covers.
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