Could a simple head tilt improve stroke recovery?

NCT ID NCT06297863

Recruiting now Disease control Sponsor: University of Milano Bicocca Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether tilting a stroke patient's head down 15 degrees for 30-90 minutes before a clot removal procedure can improve blood flow to the brain. About 118 adults with a specific type of stroke will be randomly assigned to either the head-down tilt or standard positioning. The goal is to see if this simple position change helps keep brain tissue alive and boosts the benefits of the clot removal procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: head down tilt positioning (procedure)
What this could lead to: If it works, this simple head-down tilt could improve blood flow to the brain during a stroke, potentially reducing disability and improving recovery after clot removal.
What could go wrong: This is an early phase 2 trial with only 118 participants, so results may not apply to all stroke patients. The tilt might cause discomfort, vomiting, or delays in treatment, and it is not yet proven to improve outcomes.

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Conditions

The condition(s) this trial relates to.

ischemic stroke middle cerebral artery infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE

Contacts and locations

Locations

Azienda Ospedaliera Policlinico Universitario "G. Martino"
NOT_YET_RECRUITING

Messina, 98124, Italy
Azienda Ospedaliero Universitaria Careggi
NOT_YET_RECRUITING

Florence, 50134, Italy
Azienda Ospedaliero Universitaria Policlinico Umberto I
NOT_YET_RECRUITING

Roma, 00161, Italy
Fondazione IRCCS San Gerardo dei Tintori Monza
RECRUITING

Monza, 20900, Italy
Ospedale Civile SS. Nicola e Filippo Avezzano Pronto Soccorso
NOT_YET_RECRUITING

Avezzano, 67051, Italy
Ospedale Santa Maria della Misericordia
NOT_YET_RECRUITING

Udine, 33100, Italy

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