New drug aims to stop strokes from coming back

NCT ID NCT05363397

Recruiting now Disease control Sponsor: The Florey Institute of Neuroscience and Mental Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called TBO-309, which helps prevent blood clots, in people having a stroke. It is given alongside standard treatments like clot-busting drugs or mechanical clot removal. The main goal is to see if it is safe, especially regarding bleeding in the brain, and to find the right dose. About 80 adults with acute ischemic stroke will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TBO-309 (antiplatelet drug)
What this could lead to: If successful, this could lead to a new treatment that reduces the risk of arteries re-blocking after standard stroke therapy, improving recovery.
What could go wrong: This is an early Phase 2 safety study with only 80 participants, so it may not prove effectiveness. The drug also carries a risk of bleeding in the brain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE

Contacts and locations

Locations

Eastern Health- Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
John Hunter Hospital
RECRUITING

New Lambton Heights, New South Wales, 2305, Australia
Liverpool Hospital
RECRUITING

Liverpool, New South Wales, 2170, Australia
Prince of Wales Hospital
RECRUITING

Randwick, New South Wales, 2031, Australia
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia
Royal Melbourne Hospital
RECRUITING

Parkville, Victoria, 3050, Australia
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia

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