New stroke trial combines clot removal with stenting to save brain function

NCT ID NCT05611242

Recruiting now Disease control Sponsor: Mercy Health Ohio Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether adding carotid artery stenting to standard mechanical clot removal improves recovery in people with acute ischemic stroke caused by a blockage in the internal carotid artery. About 404 participants aged 18-79 will be randomly assigned to receive either clot removal plus stenting or clot removal alone. The main goal is to see if the combined procedure leads to less disability 90 days after the stroke.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mechanical thrombectomy and carotid stenting with antiplatelet therapy
What this could lead to: If successful, this could establish a new standard procedure for treating certain types of severe stroke, potentially reducing long-term disability.
What could go wrong: This is a Phase 3 trial, but adding stenting carries risks like bleeding or vessel damage. The benefit over standard clot removal alone is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE

Contacts and locations

Locations

Albany Medical College
RECRUITING

Albany, New York, 12208, United States
Allegheny Health Network Research Institute
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Ascension/Alexian Brothers Health System
RECRUITING

Chicago, Illinois, 60606, United States
Baptist Health Research Institute
RECRUITING

Jacksonville, Florida, 32207, United States
Baptist Healthcare Systems, Inc
RECRUITING

Lexington, Kentucky, 40299, United States
Boca Raton - Baptist Health
RECRUITING

Boca Raton, Florida, 33486, United States
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Bronson Methodist Hospital/Western Michigan University Homer Stryker M.D. School of Medicine
RECRUITING

Kalamazoo, Michigan, 49007, United States
California Pacific Medical Center/Mils Peninsula Medical Center
RECRUITING

San Francisco, California, 94107, United States
DHR Health Institute for Research and Development
NOT_YET_RECRUITING

Edinburg, Texas, 78539, United States
Delray Medical Center
RECRUITING

Delray Beach, Florida, 33484, United States
Glendale Adventist Medical Center
RECRUITING

Glendale, California, 91206, United States
HCA Houston Kingwood
RECRUITING

Houston, Texas, 77004, United States
Indiana University Health Methodist Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States
JFK University Medical Center
RECRUITING

Edison, New Jersey, 08837, United States
Louisiana State University Health Sciences Center at Shreveport
RECRUITING

Shreveport, Louisiana, 71103, United States
McLaren Flint
RECRUITING

Flint, Michigan, 48532, United States
McLaren Macomb
RECRUITING

Mount Clemens, Michigan, 48043, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Mercy Health St. Vincent Medical Center
RECRUITING

Toledo, Ohio, 43608, United States
Michigan State University
RECRUITING

Lansing, Michigan, 48912, United States
Mobile Infirmary Medical Center
RECRUITING

Mobile, Alabama, 36607, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Munster Community Hospital
RECRUITING

Munster, Indiana, 46321, United States
Northwell Health- South Shore University Hospital
RECRUITING

Bay Shore, New York, 11706, United States
Northwestern Medicine Central DuPage Hospital
RECRUITING

Winfield, Illinois, 60190, United States
Ochsner Medical Center
RECRUITING

New Orleans, Louisiana, 70121, United States
OhioHealth Research Institute
RECRUITING

Columbus, Ohio, 43214, United States
Orlando Health, Inc.
RECRUITING

Orlando, Florida, 32806, United States
Piedmont Healthcare
RECRUITING

Atlanta, Georgia, 30309, United States
Pomona Valley
RECRUITING

Pomona, California, 91767, United States
Rutgers, The State University
RECRUITING

Piscataway, New Jersey, 08854, United States
SSM Health DePaul Hospital
RECRUITING

St Louis, Missouri, 63044, United States
Semmes-Murphey Foundation
RECRUITING

Memphis, Tennessee, 38120, United States
St. Mary's Medical Center
RECRUITING

West Palm Beach, Florida, 33407, United States
Sutter Institute for Medical Research
NOT_YET_RECRUITING

Sacramento, California, 95816, United States
University of California, Irvine
RECRUITING

Irvine, California, 92697, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Florida Health Jacksonville
RECRUITING

Jacksonville, Florida, 32209, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Massachusetts
RECRUITING

Worcester, Massachusetts, 01655, United States
University of Miami School of Medicine
RECRUITING

Miami, Florida, 33136, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of South Florida
RECRUITING

Tampa, Florida, 33606, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
University of Washington
NOT_YET_RECRUITING

Seattle, Washington, 98195, United States
Valley Medical Center
RECRUITING

Renton, Washington, 98055, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
WellSpan Health
RECRUITING

York, Pennsylvania, 17403, United States
WellStar Health System, Inc
RECRUITING

Marietta, Georgia, 30062, United States
West Virginia Univeristy
RECRUITING

Morgantown, West Virginia, 26506, United States

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