Can a daily pill restore sodium balance in patients with hyponatremia?
NCT ID NCT00072683
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study tests whether the drug tolvaptan can safely bring sodium and water levels back to normal in people with low blood sodium (hyponatremia). Participants take a daily tablet or a placebo for a set period. The trial focuses on patients whose hyponatremia is due to excess body water, not dehydration.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tolvaptan
- What this could lead to
- If it works, this could provide a new treatment option to correct low sodium levels and reduce related complications.
- What could go wrong
- This is a phase 3 trial, but results may not apply to all types of hyponatremia. Tolvaptan can cause side effects like thirst, dry mouth, or rapid sodium correction, which must be monitored.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HYPONATREMIAS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Study site
New York, New York, 10010, United States
-
Aurora Denver Cardiology Association
Denver, Colorado, 80218, United States
-
Baptist Clinical Research Ctr
Memphis, Tennessee, 38120, United States
-
Charlotte Heart Group Research Ctr
Port Charlotte, Florida, 33952, United States
-
Medical College of Georgia
Augusta, Georgia, 30912, United States
-
Mercury Street Medical
Butte, Montana, 59701, United States
-
Minneapolis VA Medical Center
Minneapolis, Minnesota, 55417, United States
-
Northshore University Hospital
Great Neck, New York, United States
-
Northwestern University
Chicago, Illinois, 60611, United States
-
Ohio State University Medical Center
Columbus, Ohio, 43210, United States
-
Tennessee Center for Clinical Trials
Tullahoma, Tennessee, 37388, United States
-
The Arthur P. Noyes Research Foundation
Norristown, Pennsylvania, 19401, United States
-
UCLA
Los Angeles, California, 93552, United States
-
UCSF Medical Center
San Francisco, California, 94143, United States
-
University Hospitals of Cleveland
Cleveland, Ohio, 44106, United States
-
University of Chicago
Chicago, Illinois, 60637, United States
-
University of Colorado Health Science Center
Denver, Colorado, 80262, United States
-
University of Florida Gainesville
Gainesville, Florida, 32610, United States
-
University of Iowa Hospital
Iowa City, Iowa, 52242, United States
-
University of North Carolina, Div. of Cardiology
Chapel Hill, North Carolina, 27599, United States
-
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
-
VA Greater Los Angeles Health Care Ctr
Los Angeles, California, 90073, United States
-
Washington University Ctr for Clinical Studies
St Louis, Missouri, 63110, United States