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Magnesium may boost pain relief after mastectomy

NCT ID NCT06815887

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding magnesium sulfate to a standard numbing medicine (bupivacaine) in a nerve block could improve pain control after a mastectomy. Seventy women having breast cancer surgery received either the standard nerve block or one with added magnesium. The goal was to see if the magnesium group needed less morphine and had less pain in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine and magnesium sulfate
What this could lead to
If it works, this could offer a simple, low-cost way to reduce pain and the need for strong painkillers after breast cancer surgery.
What could go wrong
This is a small, completed study with 70 participants. The results may not apply to all patients, and adding magnesium could cause side effects like low blood pressure or drowsiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

70 people

The number who actually took part.

Started

Feb 2025

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years. * Female gender. * American Society of Anesthesiologists (ASA) physical status II or III. * Patients scheduled for elective modified radical mastectomy for breast cancer. * Body mass index (BMI): \> 20 kg/m2 and \< 40 kg/m2. Exclusion Criteria: * Bleeding tendency due to coagulopathy, * Patients with opioid dependence or alcohol or drug abuse, * Significant liver and renal sufficiency * Patients with psychiatric illnesses that prevent them from proper perception and assessment of pain. * Local infection at the site of the block. * Known hypersensitivity or allergy to magnesium sulfate or local anesthetics. * Patients with chronic pain syndromes or pre-existing neuropathic pain conditions. * Pregnant or lactating individuals.

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Conditions

The condition(s) this trial relates to.

breast cancer local anesthetic poisoning Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Local anesthetic Magnesium sulfate Modified radical mastectomy Pectoral nerve Postoperative pain Stellate ganglion block

Contacts and locations

Locations

  • Cairo University

    Cairo, 12613, Egypt

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