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Old gout drug may keep heart in rhythm after valve surgery

NCT ID NCT04870424

Completed Prevention Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether colchicine, an anti-inflammatory drug used for gout, can prevent new-onset atrial fibrillation and the need for a permanent pacemaker in people undergoing transcatheter aortic valve replacement (TAVI). About 120 older adults with severe aortic stenosis were randomly assigned to receive colchicine or a placebo for 30 days after the procedure. The goal was to see if colchicine's anti-inflammatory effects could reduce common post-TAVI heart rhythm complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Colchicine
What this could lead to
If it works, this could offer a simple, inexpensive way to prevent common heart rhythm problems after valve replacement, reducing the need for a permanent pacemaker.
What could go wrong
This is a small, completed Phase 3 trial with 120 participants, so results may not apply to everyone. Colchicine can cause side effects like stomach upset, and its benefit here is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis colchicine poisoning atrial fibrillation prevention target third-degree atrioventricular block prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION NEW ONSET COLCHICINE PACEMAKER TRANSCATHETER AORTIC VALVE REPLACEMENT

Contacts and locations

Locations

  • Inselspital, Bern University Hospital, Department of Cardiology

    Bern, 3010, Switzerland

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