Poisoning

This study tests a combination of telehealth, peer support, and medication (buprenorphine) to help people with opioid use disorder stay in treatment after leaving the emergency room. The goal is to reduce repeat overdoses and prevent deaths. About 160 adults who have had an opioi…

This study tests whether giving a low, steady dose of norepinephrine during laparoscopic abdominal surgery can reduce the amount of IV fluids needed and lower the risk of lung complications afterward. It includes 130 adults at high risk for lung problems. The drug is given from t…

This early-stage trial tests whether starting a specific type of blood filtering (hemodiafiltration) immediately after a standard blood-cleaning treatment (hemoperfusion) can improve survival in people with severe diquat poisoning. Diquat is a herbicide that can cause rapid kidne…

This phase 2 trial tests two oral drugs, DMPS and marimastat, to see if they can reduce the harmful effects of snake venom. 504 adults in Brazil and Ghana who have been bitten by a snake will receive either the drug, a placebo, or standard antivenom. The goal is to find a treatme…

This early study tests whether adding the steroid dexamethasone to standard hyperbaric oxygen therapy helps prevent long-term brain problems after carbon monoxide poisoning. Twenty adults who receive hyperbaric oxygen will be randomly given either dexamethasone or a placebo. Rese…

This study tests a program called CROSSROADS for adults who recently survived an opioid or stimulant overdose. It combines standard paramedic care with free legal help for issues like housing or benefits. Researchers want to see if this reduces drug use and contact with the crimi…

This study tests whether taking vitamin C and coenzyme Q10 can prevent kidney damage in cancer patients receiving cisplatin chemotherapy. About 75 adults with various cancers who have not had chemo before will take these supplements alongside their treatment. The goal is to see i…

This study compares two treatment lengths for children who have taken too much acetaminophen (paracetamol). One group gets the standard 21-hour treatment with N-acetylcysteine, and the other gets a shorter 12-hour version. Researchers will check liver function and side effects to…

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people who have had a brain hemorrhage (a type of stroke) recover better and avoid future heart attacks or strokes. About 1,125 adults with signs of artery disease will take either colchicine or…

This pilot study tests whether a daily grape polyphenol concentrate can reduce heart damage in women receiving certain chemotherapies for breast cancer. 120 women at high risk of heart problems will take either the supplement or a placebo for three months. Researchers will measur…

This study tests a daily pill called hetrombopag to see if it can safely raise low platelet counts in women with gynecological cancers (like ovarian or cervical cancer) after chemotherapy. About 244 women whose platelets dropped too low will take the drug to help them complete th…

This study tests whether giving a combination of activated charcoal and polyethylene glycol (a laxative) can reduce the amount of toxic drugs absorbed in the gut for people with severe poisoning in intensive care. Two hundred adults on ventilators will be randomly assigned to get…

This Phase 2 trial tests whether combining two platelet-boosting drugs (hetrombopag and rhTPO) works better than hetrombopag alone for cancer patients with dangerously low platelets from treatment. About 204 adults with solid tumors will be randomly assigned to one of the two gro…

This study tests whether the drug hetrombopag can prevent severe low platelet counts caused by chemotherapy in people with nasopharyngeal carcinoma. About 35 patients who already had low platelets during a previous chemo cycle will take hetrombopag tablets daily during their next…

This study tests a drug called hetrombopag to see if it can prevent or reduce low platelet counts caused by antibody-drug conjugate (ADC) chemotherapy in breast cancer patients. The trial will include 72 adults aged 18-75. Researchers will measure how many patients develop severe…

This study compares two approaches to dialysis in people who have been severely poisoned by the herbicide diquat. One group starts dialysis right away after a blood-cleaning procedure, while the other waits until kidney damage appears. The goal is to see if earlier dialysis reduc…

This study tests a drug called Romiplostim N01 in 106 cancer patients whose platelets drop due to chemo, radiation, or immunotherapy. The goal is to see if it can safely raise platelet counts better than the current standard treatment. Patients will be randomly assigned to receiv…

This study checks if a new portable device can accurately measure diquat (a toxic herbicide) in blood samples from 60 people with suspected poisoning. The goal is to see if the new method matches the standard lab test. If successful, it could help doctors diagnose poisoning faste…

This study looks at whether advanced heart tests and blood markers can find early signs of heart damage in children who had chemotherapy or chest radiation for cancer. About 100 survivors aged 2 to 25 will undergo special echocardiograms, exercise tests, and wear activity monitor…

This study tests whether sending fentanyl test strips by mail and providing online education can reduce opioid overdoses. Researchers will enroll 100 adults who use opioids or stimulants and live in states where test strips are legal. The goal is to find the most effective and lo…

This study will test whether a 12-week program of supervised aerobic and strength exercises can prevent heart problems in 60 adults undergoing chemotherapy for cancer. Participants will be split into an exercise group and a usual-care group. Researchers will measure heart functio…

This study will test if intensive public health campaigns—including workshops, home visits, and cleaning kits—can reduce lead exposure in adults living in urban areas with known lead hazards. Researchers will compare these efforts to standard information pamphlets. The trial aims…

This study tests a program called BSAFE that uses counseling, text reminders, and help connecting to care to reduce overdose risk in people who use stimulants like cocaine or methamphetamine and may accidentally use fentanyl. 160 adults will be randomly assigned to the BSAFE prog…

This study tests a mobile app called PA-LINKS designed to help women who have recently been in jail or prison access HIV prevention medicine (PrEP) and treatment for opioid use disorder. About 74 women will use the app and work with a navigator to connect to these services. The g…

This study tests whether taking a low dose of colchicine (0.5 mg) every day for two years after coronary artery bypass grafting (CABG) can prevent the new blood vessel grafts from failing. About 622 adults who just had bypass surgery will be randomly assigned to get either colchi…

This study tests whether taking S-adenosylmethionine (SAMe), a natural supplement, can prevent liver injury caused by the chemotherapy drug oxaliplatin. About 30 adults with colorectal cancer that has spread to the liver will take SAMe pills daily for 3-6 months alongside their c…

This study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…

This study tests a new treatment called DA-020 to prevent hair loss in people with early-stage breast cancer receiving chemotherapy. About 60 participants will use DA-020 during their chemo sessions. The goal is to see if it can reduce hair loss and help hair grow back faster aft…

This study tests if a special light (photobiomodulation) can prevent and treat painful mouth sores caused by chemotherapy in children aged 4-17 with cancer. Half of the 49 participants will get light therapy, and the other half will get a standard gel. The goal is to see if the l…

This study tests whether foot reflexology, a gentle foot massage technique, can help reduce nausea and vomiting caused by chemotherapy in breast cancer patients. Fifty women receiving chemotherapy will be split into two groups: one gets standard care plus foot reflexology, the ot…

This study tests whether adding acupuncture to standard care can lower the risk of hospital stays for a serious chemo side effect called febrile neutropenia (fever with low white blood cells). About 60 adults with sarcoma receiving doxorubicin chemotherapy will be randomly assign…

This Phase 2 trial tests an oral drug called AND017 for cancer-related anemia caused by chemotherapy. About 36 adults with non-myeloid cancers and low hemoglobin will take AND017 three times a week for 6 weeks. The goal is to see if it safely raises hemoglobin levels and reduces …

This study tests whether giving lidocaine through a vein during surgery, plus injecting ropivacaine into the surgical cuts, helps people recover better after laparoscopic colon cancer surgery. About 182 adults will be randomly assigned to get either the lidocaine plus ropivacaine…

This study tests a new form of the drug megestrol acetate (nano-crystalline) combined with a standard anti-nausea medicine to prevent nausea and vomiting caused by chemotherapy. It involves 127 people with stomach cancer who are starting their first chemotherapy. The goal is to s…

This study tests a highly absorbable form of curcumin (from turmeric) in 72 adults with mid-to-low rectal cancer who are getting chemoradiation before surgery. The goal is to see if curcumin can reduce severe gut side effects like diarrhea and rectal pain. Researchers will also c…

This study tests whether a probiotic called Clostridium butyricum can reduce severe diarrhea and other side effects in people getting chemotherapy for colorectal cancer. About 238 adults who had surgery for colorectal cancer and need chemo will take either the probiotic or a plac…

This study tests a bundle of smartphone-based tools, including a mobile health app and other online resources, to see if they are practical and helpful for people who use drugs. The goal is to lower overdose risk by improving access to prevention services. Forty participants will…

This study will give 22 occasional cannabis users oral THC, CBD, both, or a placebo to measure how these substances appear in blood and saliva, and how they affect thinking and behavior. The goal is to better understand drug detection and impairment from oral cannabinoids. It is …

This study looks at how the numbing drug levobupivacaine behaves in the blood after a TAP block, a common pain relief procedure for abdominal surgery. Researchers will take blood samples from 26 adult patients over three hours to measure drug levels. The goal is to find a safe ti…

This study looks at whether a special training program can help supportive housing agencies in New York and New Jersey use proven methods to prevent overdoses and improve tenant health. About 24 agencies and 2940 people will take part. The goal is to see how well agencies adopt t…

This study looks at how tobacco smoke exposure before birth—whether from active smoking or secondhand smoke—affects a newborn's health right after delivery. Researchers will measure a chemical called cotinine in the baby's cord blood to classify exposure as active, passive, or no…

This study looks at how communities can better use deflection programs—which guide people with substance use toward treatment instead of arrest. Researchers will test two community engagement strategies across 20 communities in five states. The goal is to see which approach impro…

This early-stage study tests a drug called DA-020 in 60 healthy women aged 18-55. The goal is to measure how much of the drug enters the blood after one application to the scalp and to check for side effects like blood pressure changes. This research helps understand the drug's s…

This study will look back at medical records of 100 adults in France who were admitted to intensive care after swallowing a caustic substance (like strong acid or bleach). The goal is to find which factors best predict who survives and who has complications. No new treatments are…

This study looks at how overdose prevention centers (OPCs) in New York City impact the risk of fatal and non-fatal overdoses, as well as mental health crises, among adults who use multiple drugs. Researchers will track 500 people who use OPCs or syringe services to see if these c…

This study tests whether a lead exposure prevention program originally designed for the US can work in Nairobi, Kenya. About 500 caregivers of children aged 1-6 will either get lead risk information only at a clinic or also receive a home visit with tailored advice. Researchers w…

This study looks at how the cholesterol-lowering drug rosuvastatin affects fitness and muscle symptoms in people who run long distances at least three times a week. Researchers will compare runners taking rosuvastatin to those not taking it over three months, measuring changes in…

This study looks at whether taking iron pills every other day causes fewer stomach problems than taking them daily in pregnant women. About 50 pregnant women who need iron will try an every-other-day schedule for a week, then daily for a week, and report any side effects. The goa…

This study tests whether digital messages created by sex trafficking survivors can encourage more HIV, STI, and hepatitis C testing, as well as use of overdose prevention kits. About 368 survivors in New York City will be randomly assigned to see either survivor-made messages or …

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study looks at how thalassemia patients in Greece feel day-to-day while taking a standard iron-removing medicine called deferasirox. Researchers will survey 150 adults to measure their physical and mental well-being. The goal is to understand real-world quality of life, not …

This study looks at how often women with early-stage breast cancer experience taste changes during chemotherapy. Researchers will use taste tests to measure changes in sweet, sour, salty, and bitter perception. They will also check how these changes affect nutrition and quality o…

This study looks at 38 women who had pelvic side effects (like pain in the rectum, bladder, or vagina) after radiation or chemotherapy for gynecological cancers. Researchers will compare their gut bacteria to healthy controls and see if rectal ozone therapy changes the microbiome…

This study tests whether a computer alert that pops up when a doctor prescribes too much digoxin can reduce risky prescribing in hospitalized patients aged 65 and older. Digoxin is a heart medication that can cause serious side effects if the dose is too high. The study will comp…

This study will check if certain blood markers can predict heart damage in children and teens who had anthracycline chemotherapy for cancer. Researchers will compare blood tests and heart imaging results from 40 survivors and healthy volunteers. The goal is to find early warning …

This study will survey 32,000 households in Ghana and Rwanda to understand where snakebites happen most. Researchers will use GPS and computer models to create risk maps. The goal is to help health officials send antivenom to the areas that need it most and plan prevention effort…

This study will monitor 52 adults after surgery to see if the timing of opioid painkillers affects breathing problems. Participants will wear a noninvasive breathing monitor in the recovery room. The goal is to find a link between when opioids are given and drops in breathing fun…