Acute opioid poisoning

This Phase 2 trial tests a single dose of CS-1103 in 16 healthy adults who also receive fentanyl (a strong opioid) and naloxone (an overdose reversal drug). The goal is to see if CS-1103 is safe and how it affects fentanyl levels in the body. It is an early study to gather safety…

This study tests whether showing doctors a warning flag in electronic health records for patients at high risk of opioid overdose can lead to safer prescribing. About 1,350 adults who recently received an opioid prescription will be included. Doctors in some clinics will see a si…

This study tests whether a smartphone app called UnityPhilly can help bystanders quickly respond to opioid overdoses with naloxone. About 450 adults who live or work in three Philadelphia neighborhoods will use the app and receive training. Researchers will track how many overdos…

This study tests a combination of telehealth, peer support, buprenorphine medication, and connections to addiction treatment programs for people who have had an opioid overdose and visited the emergency department. The goal is to help participants stay in treatment and prevent fu…

This pilot study is testing whether giving activated charcoal within 6 hours of swallowing a poisonous substance can prevent the poison from getting worse and shorten hospital stays. About 100 adults and children who have ingested a substance that charcoal can absorb will be rand…

This study explores whether trained volunteers with the overdose-reversal drug naloxone can reach people having an opioid overdose faster than emergency services. About 1,000 volunteers will be alerted via a smartphone app when a suspected overdose is reported. The goal is to see…

This study tests a community program called Young HEROES for youth aged 12-17 with opioid use disorder. It combines medication, counseling, and peer support to help them stay in treatment and stop using opioids. The goal is to see if this approach works better than usual care in …

This study tests whether a monthly injection of naltrexone can prevent fentanyl overdose in people who use stimulants like cocaine or methamphetamine but do not intentionally use opioids. One hundred participants will either receive the shot or standard harm reduction supplies. R…

This study tests whether a computer alert can help doctors remember to prescribe blood-thinning medicine for high-risk patients after they leave the hospital. Blood clots are a serious risk for some hospitalized patients, even after discharge. The trial will include 400 adults ag…

This study looks at whether a device that measures pupil reactions can help identify children at risk for opioid-induced respiratory depression after tonsillectomy. About 300 children will have their pupils measured before, during, and after surgery. The goal is to see if pupil p…

This study is building a Canada-wide registry of people who come to emergency departments with opioid poisoning. Researchers will track treatments and outcomes for up to 7,200 patients. The goal is to learn what works best and create a tool to predict who is at highest risk of dy…

This study is testing a new way to reduce opioid overdoses on Chicago's West Side. Researchers will train friends and family members of people who use opioids to become harm reduction champions. These champions will learn about tools like naloxone and fentanyl test strips, and th…