New drug could stop fentanyl overdoses in their tracks
NCT ID NCT07459166
First seen Mar 19, 2026 · Last updated Jun 23, 2026 · Updated 11 times
Summary
This early-phase trial tests a single dose of an experimental drug called CS-1103 in 16 healthy adults who have had opioids before. Participants receive fentanyl (a strong painkiller) along with naloxone (an overdose reversal drug) to ensure safety. The goal is to see if CS-1103 is safe and how it affects fentanyl levels in the body, potentially leading to a new way to treat opioid overdoses.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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California Clinical Trials Medical Group
RECRUITINGGlendale, California, 91206, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CS-1103 (an experimental drug given intravenously)
What this could lead to
If successful, this could lead to a new treatment to reverse fentanyl overdoses, potentially saving lives during the opioid crisis.
What could go wrong
This is a very early, small trial in only 16 healthy people, not real overdose patients. It may not work or be safe in actual emergencies.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.