Acute opioid poisoning
MONDO:0018173Acute opioid poisoning is a rare intoxication with opioids, a large group of alkaloid analgesics, mainly characterized by miosis (pinpoint pupil), respiratory depression (bradypnea/apnea) and central nervous system depression (sedation or coma). Other manifestations include hypotension, reduced bowel motility, hypothermia and hypoglycemia. Naloxone, a competitive inhibitor of the mu-opioid receptor, is a potent antagonist and is used as the antidote for opioid intoxication.
33 clinical trials for this condition and its sub-types.
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Pharmacists on the frontline: new study aims to cut opioid overdose deaths after prison
Disease control CompletedThis study tested whether a pharmacist-led program could help people leaving jail get treatment for opioid use disorder and prevent overdoses. Participants received overdose training, Narcan nasal spray, counseling, and referrals to medication treatment after release. The goal wa…
Phase: NA • Sponsor: University of Arkansas • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Ohio courts hand out Life-Saving overdose prevention kits
Prevention CompletedThis study looked at whether giving fentanyl test strips and naloxone to people in Ohio drug courts could help prevent overdoses from stimulants mixed with opioids. Over 650 adults who used stimulants in the past 6 months took part. Researchers tracked how many people used the ki…
Phase: NA • Sponsor: Nationwide Children's Hospital • Aim: Prevention
Last updated Jun 27, 2026 08:13 UTC
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App aims to turn bystanders into lifesavers against opioid overdoses
Prevention CompletedThis study tested a new system called the Opioid Rapid Response System (ORRS) that uses a smartphone app to train and alert everyday people to respond to opioid overdoses with the life-saving drug naloxone. Over 700 adults from communities using the PulsePoint app took part. The …
Phase: NA • Sponsor: University of Missouri-Columbia • Aim: Prevention
Last updated Jun 27, 2026 08:13 UTC
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New nalmefene study could speed up opioid overdose rescue
Knowledge-focused CompletedThis study tested how a new form of nalmefene (a drug that reverses opioid overdoses) behaves in the body when given as a shot or through an IV. 13 healthy adults received single doses of both the new and standard versions. The goal was to see how quickly the drug reaches the blo…
Phase: PHASE1 • Sponsor: Knoa Pharma LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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New naloxone spray tested for faster overdose help
Knowledge-focused CompletedThis study tested a new device (AP003) that delivers naloxone as a nasal spray to reverse opioid overdoses. Twenty-four healthy adults received multiple doses to see how the drug moves through the body and to check for side effects. The goal was to compare the new spray with an e…
Phase: PHASE1 • Sponsor: Emergent BioSolutions • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Can a computer predict overdose outbreaks? rhode island trial tests new tool
Knowledge-focused CompletedThis study tested a predictive analytics tool called PROVIDENT to forecast where overdose deaths might happen next. Researchers randomly assigned 39 Rhode Island municipalities to either use the tool or continue with standard prevention efforts. The goal was to see if directing r…
Phase: NA • Sponsor: Brown University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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ER study sheds light on hidden xylazine in opioid overdoses
Knowledge-focused CompletedThis study measured the amount of xylazine—a dangerous animal sedative often mixed with opioids—in the blood and urine of 75 emergency room patients who had a non-fatal opioid overdose. The goal was to see how common xylazine is and how well test strips can detect it. The finding…
Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC