Acute opioid poisoning
MONDO:0018173Acute opioid poisoning is a rare intoxication with opioids, a large group of alkaloid analgesics, mainly characterized by miosis (pinpoint pupil), respiratory depression (bradypnea/apnea) and central nervous system depression (sedation or coma). Other manifestations include hypotension, reduced bowel motility, hypothermia and hypoglycemia. Naloxone, a competitive inhibitor of the mu-opioid receptor, is a potent antagonist and is used as the antidote for opioid intoxication.
33 clinical trials for this condition and its sub-types.
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New ER discharge plan aims to stop opioid overdose deaths
Disease control Not yet recruitingThis study tests a combination of telehealth, peer support, and medication (buprenorphine) to help people with opioid use disorder stay in treatment after leaving the emergency room. The goal is to reduce repeat overdoses and prevent deaths. About 160 adults who have had an opioi…
Phase: PHASE4 • Sponsor: University of Alabama at Birmingham • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Mailed test strips aim to slash opioid overdose deaths
Prevention Not yet recruitingThis study tests whether sending fentanyl test strips by mail and providing online education can reduce opioid overdoses. Researchers will enroll 100 adults who use opioids or stimulants and live in states where test strips are legal. The goal is to find the most effective and lo…
Phase: NA • Sponsor: University of Alabama at Birmingham • Aim: Prevention
Last updated Jul 03, 2026 00:00 UTC
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New app aims to cut HIV and overdose risk for women leaving jail
Prevention Not yet recruitingThis study tests a mobile app called PA-LINKS designed to help women who have recently been in jail or prison access HIV prevention medicine (PrEP) and treatment for opioid use disorder. About 74 women will use the app and work with a navigator to connect to these services. The g…
Phase: NA • Sponsor: Temple University • Aim: Prevention
Last updated Jun 27, 2026 12:33 UTC
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New tool aims to prevent opioid overdose during dose tapering
Prevention Not yet recruitingThis study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…
Sponsor: University of Colorado, Denver • Aim: Prevention
Last updated Jun 27, 2026 12:23 UTC
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Timing of painkillers may prevent breathing trouble after surgery
Knowledge-focused Not yet recruitingThis study will monitor 52 adults after surgery to see if the timing of opioid painkillers affects breathing problems. Participants will wear a noninvasive breathing monitor in the recovery room. The goal is to find a link between when opioids are given and drops in breathing fun…
Sponsor: Wayne State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC