New alert aims to curb opioid overdoses by nudging doctors to Co-Prescribe naloxone

NCT ID NCT06271668

Ongoing Disease control Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a computer alert that reminds doctors to prescribe naloxone—a drug that reverses opioid overdoses—alongside high-risk opioid prescriptions. The alert appears when a doctor orders an opioid for patients aged 12-89 (excluding those with cancer or hospice care). Researchers will compare how often naloxone is co-prescribed with and without the alert, and track overdose rates over six months. The goal is to make it easier for doctors to follow best practices and save lives.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: naloxone
What this could lead to: If successful, this alert could increase naloxone prescribing and help prevent opioid overdoses.
What could go wrong: The alert may not change doctor behavior, or patients may not fill the naloxone prescription. The study is observational, so it cannot prove cause and effect.

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Conditions

The condition(s) this trial relates to.

acute opioid poisoning Harm Reduction Opiate Overdose substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HARM REDUCTION MEDICATION ABUSE OPIOID OVERDOSE OPIOID PRESCRIBING

Contacts and locations

Locations

University of Colorado Hospital

Aurora, Colorado, 80045, United States

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