Can blister-pack painkillers replace opioids after wisdom teeth removal?
NCT ID NCT06275191
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a simple program—including an education session for oral surgeons, patient instruction sheets, and blister packs of acetaminophen and ibuprofen—can reduce opioid prescriptions to adolescents and young adults after tooth extraction. About 38,000 patients and their surgeons will take part. The goal is to see if these alternatives can safely manage pain while cutting down on opioid use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- acetaminophen and ibuprofen
- What this could lead to
- If successful, this could provide a safer, non-opioid pain management approach for young dental patients, reducing opioid misuse risk.
- What could go wrong
- This is a behavioral intervention study, not a drug trial, so results depend on surgeon compliance and may not change prescribing habits broadly. It also focuses only on short-term pain after tooth extraction.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Kentucky
Lexington, Kentucky, 40536, United States
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