Hip fracture

This phase 4 trial will test whether tranexamic acid (TXA), a drug that reduces bleeding, can safely lower blood loss in 200 orthopedic trauma patients who are on anticoagulants (blood thinners). Participants will have surgery for broken leg or thigh bones. The study compares tho…

This study looks at whether a single nerve block, given before surgery, can reduce the risk of heart muscle damage in older adults who have hip fracture surgery more than 48 hours after injury. Researchers will review medical records of 500 patients aged 65 and older, comparing t…

This trial compares two ways to humidify air for trauma patients on prolonged mechanical ventilation: active heated humidifiers and passive heat-and-moisture exchangers. The goal is to see which method reduces airway complications like mucus plugs and tube blockages, and improves…

This study tests whether a new shelf-stable blood product (IFC) works faster than the standard cryoprecipitate to stop severe bleeding in trauma patients. About 320 adults with traumatic injuries and low fibrinogen levels will be enrolled. The goal is to see if IFC can be given m…

This study compares robot-assisted surgery to conventional surgery for treating unstable pelvic fractures (Tile B and C types). About 88 adults with recent fractures will be randomly assigned to one of the two procedures. Researchers will measure pain, function, recovery speed, a…

This study will review medical records and call patients who received AGN1 LOEP, a device injected into the hip bone to treat osteoporosis. Researchers want to see how many patients later had hip fractures and whether any side effects occurred. The goal is to understand how well …

This trial tests a new type of nail made from magnesium and titanium to fix broken leg or arm bones. The nail is designed to provide strong support while part of it gradually dissolves over time. Researchers will compare it to standard metal nails in 160 adults to see if it is ju…

This study looks at whether applying a patient's own skin cells (called a basal cell suspension) to surgical wounds can help them heal faster and with less scarring. Researchers will compare 500 people who get this extra treatment with 500 who get standard surgery alone. The goal…

This study is testing whether adding a cold atmospheric plasma device to standard wound care helps different types of wounds heal better. The device uses low-temperature plasma to kill bacteria and promote healing. Researchers will compare 500 patients who get plasma therapy plus…

This study looks at two different surgical methods for repairing a broken hip (hemiarthroplasty) in 100 adults. The goal is to see if one approach leads to better function and fewer complications after surgery. Participants will be randomly assigned to one of the two methods and …

This study will test a new, personalized smart home care model for older adults (60+) recovering from a hip fracture. The goal is to predict and improve recovery, reduce falls, and support caregivers. About 218 people from northern Taiwan will take part.

This study will compare aspirin tablets to daily injections of low molecular weight heparin (LMWH) for preventing dangerous blood clots in people who break their hip. Over 21,000 patients aged 60 and older across 96 UK hospitals will take part. Hospitals will switch between the t…

This study looks at whether using both a nail and a plate together can better fix certain complex hip fractures. The approach is meant to prevent the bone from collapsing and help people heal faster. Seventeen adults with these fractures will be followed for six months to check b…

This pilot study tests whether a combination of two blood thinners (rivaroxaban and aspirin) can prevent heart attacks and blood clots in patients who had a hip fracture surgery and also suffered a heart injury. About 100 adults aged 45 and older will be randomly assigned to eith…

This study asks whether a simple ultrasound scan can safely and accurately track how well a child's broken bone is healing, compared with the standard X-ray. Children with fractures often need several X-rays during recovery, exposing them to small amounts of radiation. The trial …

This study tests whether an AI software called RBfracture helps clinicians better identify fractures, dislocations, and joint fluid buildup on X-rays. Sixteen doctors will review X-rays from 415 adult patients with and without the AI's help. The goal is to see if the AI improves …

This study tests whether a higher dose of the blood thinner enoxaparin can better prevent dangerous blood clots in the legs or lungs of severely injured patients. About 540 adults in intensive care after trauma will receive either the standard or a double dose. The goal is to see…

This trial tests whether giving a nerve block called a fascia iliaca compartment block (FICB) right after hospital admission, before hip fracture surgery, can improve recovery in patients aged 65 and older. Half of the 144 participants will receive the early block, while the othe…

This study tests whether a single injection of a slow-release painkiller (liposomal bupivacaine) into a nerve block can control pain for up to 72 hours after hip fracture surgery in older adults. The standard drug only lasts about 12 hours, often leading to more pain and opioid u…

This trial tests whether a structured educational program, including an illustrated booklet, can improve recovery after hip fracture surgery. Participants are randomly assigned to receive the program plus routine care or routine care alone. The study measures functional independe…

This study tests whether using a virtual reality (VR) headset during hip replacement surgery can lower anxiety and prevent post-surgery confusion in older adults. Half of the participants will watch calming nature scenes through VR while under regional anesthesia, while the other…

This trial tests whether adding a specific nerve block (Quadro-Iliac Plane Block or Suprainguinal Fascia Iliaca Block) to standard pain management reduces the need for opioids after hip fracture surgery. About 90 adults having hip fracture surgery under spinal anesthesia will be …

This study tests whether giving iron supplements to older adults (75+) after hip fracture surgery can reduce fatigue and improve recovery. 528 participants will receive either intravenous iron, oral iron pills, or a placebo. The goal is to see if iron helps with energy, mobility,…

This study tests if using a floor pedal bike at home helps people recover from leg fractures and ankle injuries. Twenty adults with these injuries will get a bike at their first post-surgery visit and be asked to use it regularly. Researchers will track their physical activity an…

This study tests whether a device called TENS, which sends mild electrical pulses through the skin, can reduce pain and the need for painkillers in older adults with hip fractures. Thirty-two participants will receive either active TENS or a sham (fake) version for 45 minutes. Re…

This study looks at whether adding a nerve block to the back of the hip to two standard front-hip blocks can improve pain relief after hip surgery. About 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine in the …

This study tests whether an AI-based smartphone app can improve recovery for 106 adults after hip or knee replacement or hip fracture surgery. Participants use the app for 12 weeks at home to get real-time feedback on their exercises, while a comparison group follows the same exe…

This study looks at whether abdominal massage and drinking warm water can prevent constipation and improve recovery in people who have had hip fracture surgery. About 81 adults will be randomly assigned to receive massage, warm water, or standard care. The goal is to see if these…

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study compares two spinal anesthesia methods for hip fracture surgery in people over 50. One method uses a single injection, the other uses a tiny tube to give the medicine in smaller doses. The goal is to see if the tube method causes fewer drops in blood pressure and relat…

This study looks at whether giving trauma patients personalized information and a voluntary digital follow-up visit (instead of only standard care) helps them have less disability, return to work more often, and feel better overall. About 256 adults admitted to a Norwegian trauma…

This study will compare one-on-one physical therapy sessions with group-based therapy for people recovering from a femoral neck fracture (a type of hip fracture). Forty adults aged 50 and older in Gaza will be randomly assigned to either individual or group therapy for 6 weeks. R…

This study looks at whether nutritional risk and muscle thickness can help predict recovery in adults aged 65 and older after hip fracture surgery. Researchers will measure nutritional status using a standard score and check muscle thickness in the thigh with a quick, painless ul…

This observational study aims to build and test models that predict risks like delirium and death after fracture surgery in older adults. Researchers will collect data on pain, sleep quality, and brain activity to see how these factors relate to short- and long-term outcomes. The…

This study watches 250 adults with broken leg or pelvis bones to see who develops hemorrhagic shock — a dangerous drop in blood pressure from blood loss. Researchers want to know which fractures are most likely to cause this emergency. The goal is to help doctors quickly spot and…

This study aims to create a guide that helps frail older adults with hip fractures choose treatments based on what matters most to them, such as walking ability or independence, rather than just survival. Researchers will review existing studies, analyze NHS data, and interview p…

This study investigates why some people who have surgery for broken bones go on to develop long-term pain. Researchers are collecting blood samples and information on medical, psychological, and social factors from 600 adult patients. The goal is to create a model that can predic…

This trial tests a software device called AI-TRiPS that uses real-time data from ambulances to predict the risk of death, bleeding, kidney injury, and need for blood transfusion in trauma patients. The tool displays these predictions to hospital trauma teams before the patient ar…

This study checks if a French version of the New Mobility Score (NMS) works well for older adults hospitalized after a hip fracture. The NMS is a simple test that measures how well a person can move indoors, outdoors, and while shopping. Researchers will test it with 100 patients…

This study will train over 1,800 lay first responders—like taxi drivers and shopkeepers—in Cameroon to provide basic first aid and safe transport for injured people. Researchers will compare survival rates before and after the training program. The goal is to see if a data-driven…

This study will test a new program designed to help people who have been hospitalized for a physical injury. The program connects survivors with resources to meet their medical and social needs. Researchers will interview 25 participants and track which resources they use to see …

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

This study watches real conversations between healthcare staff and people with dementia after hip fracture surgery. The goal is to find which words and phrases work best to encourage patients to stand or walk early. Researchers will record up to 50 care sessions on hospital wards…

This study looks at 400 severely injured patients treated by emergency medical teams in the Paris region. It aims to see if the time spent on scene before going to the hospital affects whether patients survive the first 24 hours. The goal is to find ways to improve emergency care…

This study looks at whether a special hospital program for older adults (65+) who need surgery can improve their outcomes. Researchers will compare patients treated before and after the program started, tracking deaths and complications within 28 days. About 150 participants will…

This study will analyze data from a pediatric trauma registry to understand injury patterns, outcomes, and what factors predict how severe an injury is. Researchers will look at records of 40 children under 18 who came to the hospital with a traumatic injury. The goal is to learn…

This study tests whether giving metoclopramide alone or with dexamethasone can speed up stomach emptying in trauma patients needing emergency surgery. Using bedside ultrasound, researchers will measure stomach contents to see which drug works better. The goal is to reduce the ris…

This study looks at 100 elderly patients with hip fractures to see if quick, easy tests like muscle ultrasound, handgrip strength, and routine blood work can predict frailty. Frailty affects recovery after surgery, so finding a fast way to measure it could help doctors provide sa…

This observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…

This study will look back at the medical records of about 2000 older adults (60+) who had surgery for a broken bone in Shanghai between 2010 and 2019. Researchers want to see how factors like age, nutrition, and which bone broke affect the risk of dying within 1, 3, or 5 years af…