SURGERY

This study is testing whether a special care team focused on older adults can improve recovery after colon cancer surgery. It will compare the new team approach to standard hospital care for 90 patients aged 70 and over. The main goal is to see if this approach helps patients reg…

This study is testing the safety and initial performance of a new surgical device called the CellFX Cardiac Clamp. It is designed to treat atrial fibrillation (a type of irregular heartbeat) in patients who are already scheduled for other heart surgeries, like valve repair or byp…

This large study aims to find the best pre-surgery treatment combination for patients with esophageal cancer, which has a low survival rate. Researchers will compare different approaches, including chemotherapy, radiation, immunotherapy, and targeted drugs, given before surgery. …

This study compares two sedation drugs (remazolam besylate vs dexmedetomidine) for patients who need breathing machine support in the ICU after non-cardiac surgery. It aims to see if the new drug is at least as safe and effective at helping patients wake up and breathe on their o…

This study is testing a new hospital program called '5 Rs to Rescue' designed to prevent deaths after surgery. It will run in 20 hospitals across Ethiopia, South Africa, Tanzania, and Uganda, involving 6,000 adult patients. The program teaches staff a 5-step system to better spot…

This study is testing if more frequent monitoring of vital signs after major surgery helps patients recover better. It will compare patients who receive continuous monitoring in the hospital and at home for a few days to those who get standard, less frequent checks. The main goal…

This study is testing a new, gentle pressure technique on a child's neck during anesthesia to prevent air from going into the stomach. It aims to make mask ventilation safer for children aged 2-10 having elective surgery. Researchers will use ultrasound to see if the technique wo…

This study aims to see if two common, low-cost drugs can safely reduce dangerous bleeding during surgery for people with advanced kidney disease. It will enroll 100 patients with severe kidney problems who are having non-heart surgery. The trial is a pilot to prepare for a larger…

This study is testing a machine that keeps donated livers functioning outside the body, allowing doctors to assess their quality. The goal is to see if this process can safely increase the number of livers available for transplant, helping more patients get a transplant sooner. R…

This international study compares two types of minimally invasive surgery for removing benign or pre-cancerous tumors from the left side of the pancreas. 256 patients will be randomly assigned to either laparoscopic (traditional keyhole) surgery or robot-assisted surgery, with ne…

This study is testing a new computer system designed to help doctors decide which surgery patients need blood prepared in advance. It aims to ensure patients who need a transfusion can get one safely, while avoiding unnecessary preparation and waste for those who likely won't. Th…

This study is testing a device called FreeO2 that automatically adjusts oxygen levels for patients in the hospital. It is being used with patients who have a severe COPD flare-up or who are recovering from weight-loss surgery. The goal is to see if the device can keep patients' o…

This study is testing a special support program designed to help older women with advanced ovarian cancer better withstand and recover from major surgery. The program includes nutritional advice, physical exercise, and education before surgery, followed by coordinated care during…

This study is monitoring the long-term safety and performance of approved stent-grafts used to treat dangerous bulges in the body's main artery (aortic aneurysms). It will follow 1,000 patients who receive these devices as part of their standard care to track complications, survi…

This study is testing if a technique called 'systematic shaving' during breast-conserving surgery can help surgeons remove all the cancer in one operation. It compares the new shaving method to standard surgery in 234 patients to see if it leads to fewer cases where cancer cells …

This study is testing whether using a smart scale can help people maintain their weight loss after obesity surgery. It will involve 182 adults who had surgery about a year ago. Half will use a connected scale weekly, which sends data to their care team and triggers alerts if weig…

This study aims to find the most effective surgery for pilonidal sinus, a painful skin condition near the tailbone that often comes back after treatment. It will compare four different surgical methods in 80 teenagers aged 12 to 18. The goal is to identify which procedure causes …

This study aims to see if a precise, ultrasound-guided injection can work as well as minor surgery for treating carpal tunnel syndrome. It will involve 60 people with the condition, who will be randomly assigned to receive either the injection or the surgical procedure. Researche…

This study aims to find the best way to recover after surgery for a torn ankle tendon. Fifty patients in Sweden will be randomly assigned to one of two different rehab plans after their operation. One plan uses a cast for six weeks, while the other switches to a supportive brace …

This study is testing a new 3D imaging tool designed to help surgeons during head and neck cancer operations. Researchers will use a smartphone app to create 3D models from standard medical scans before surgery. The goal is to see if combining these 3D models with regular scan in…

This study is for women with early-stage endometrial (uterine) cancer. It compares two surgical approaches after removing the uterus: one uses a dye to find and check just one or two 'sentinel' lymph nodes, while the other skips checking lymph nodes altogether. The main goals are…

This study is testing a new monitoring system designed to detect strokes earlier than current methods in high-risk hospital patients. Participants wear a device on each arm for up to five days to look for signs of stroke, like sudden weakness on one side. The main goals are to se…

This study aims to validate two new test kits designed to identify which early-stage lung cancer patients are at highest risk of their cancer returning after surgery. Researchers will test these kits on 236 patients who have had their lung tumors completely removed. The goal is t…

This study is testing whether an educational video increases interest in a preventive surgery to remove the fallopian tubes, which may help lower ovarian cancer risk. Researchers will ask women aged 45+ who are already scheduled for other abdominal surgery to watch the video and …

This study aims to find the most effective way for people to safely dispose of unused prescription opioid pain medications after outpatient surgery. Researchers will compare two methods: a mail-back kit versus in-home disposal products. The goal is to prevent leftover pills from …

This large UK study aims to find out if wearing compression stockings in the hospital provides any extra benefit for preventing blood clots when patients are already taking extended blood-thinning medication after high-risk surgery. It will enroll over 8,600 patients to compare t…

This study is testing whether two over-the-counter supplements, CoQ10 and Glutathione, can prevent kidney injury in patients undergoing elective heart bypass surgery. About 242 participants will receive either the supplements or a placebo starting the day before surgery and conti…

This study tests whether a specific nerve surgery technique performed during leg amputation can prevent the severe chronic pain that often follows. Researchers are comparing the standard method of cutting nerves to a newer technique called targeted muscle reinnervation (TMR), whi…

This study is testing whether using virtual reality (VR) can help patients feel less anxious before heart surgery, so they might not need as much anxiety medication. It will involve 40 adults who are scheduled for elective surgery and who have already asked for medication to calm…

This study is testing whether a home physical therapy program helps people recover better from endometriosis surgery. Researchers will compare patients doing guided home exercises after surgery to those receiving standard post-op care. The goal is to see if the exercises improve …

This study is testing whether using a special walking platform every day helps older adults (age 65+) recover their normal walking speed after cancer surgery. Researchers will compare patients who use the platform to those who receive standard care. The main goal is to see if mor…

This study is testing a wellness program designed for older Black patients who are scheduled for surgery and are feeling depressed or anxious. The main goal is to see if the program is practical to run and if patients find it helpful. Researchers will measure how many eligible pa…

This study is testing if spraying a cooling substance (ethyl chloride) on the skin can reduce the pain of the numbing injections given before a common skin cancer surgery. It involves 80 patients having the surgery. Each patient will have the spray used on one half of their surgi…

This study is testing whether listening to music can help patients feel less anxious during hand surgery performed while they are awake. Researchers are comparing the effect of patients listening to their own choice of music versus a standard set of relaxing music. About 170 adul…

This study is testing a new 'smart' pain pump that adjusts medication based on a patient's needs, comparing it to a standard pump. It aims to see if the smart pump can use less opioid pain medication while providing better pain relief and fewer side effects for adults recovering …

This study aims to find the best method for managing pain after open-heart surgery. It will compare two different ultrasound-guided nerve-block techniques given to patients during surgery. The main goal is to see which method provides better pain relief and reduces the need for s…

This study aims to find the best way to manage children's pain after they go home from common surgeries like tonsil or gallbladder removal. Researchers will compare two standard medication approaches: one using common pain relievers (NSAIDs plus acetaminophen) and another adding …

This study aims to find the best and safest way to manage pain after common surgeries like gallbladder removal, hernia repair, and breast lump removal. It will compare two standard medication plans: one using common pain relievers like ibuprofen and acetaminophen, and another usi…

This study is testing two different 'smart' pain pump methods to see which one works better for managing pain after surgery. It will involve 450 adults having various planned surgeries. The goal is to find a method that uses less opioid medication while still controlling pain eff…

This study is testing if a simple, 20-minute mandala coloring activity can help reduce anxiety and stress in people waiting for elective surgery. Researchers will compare 60 patients who do the coloring with those who receive standard care, measuring their anxiety, stress, and vi…

This study is testing if a simple, relaxing hot water foot bath can help patients feel less anxious before surgery to remove a pituitary tumor. Researchers will have 100 patients either soak their feet in warm water for 20 minutes before surgery or simply rest. They will then com…

This study is testing if giving a single dose of the steroid dexamethasone right before a specific type of minimally invasive spine fusion surgery can better control pain after the operation. Researchers want to see if this approach reduces patients' back pain, lowers their need …

This study aims to find out if a specialized stabilization exercise program works better than standard exercises for people recovering from neck surgery. Researchers will compare two groups of 36 patients to see which program more effectively reduces pain, improves movement and b…

This study is testing whether daily exposure to bright green light can help people feel better after surgery. Researchers will compare patients using the green light to those in normal room light to see if it reduces pain, lowers the need for opioid painkillers, and improves slee…

This study is testing whether eating a light meal before a specific type of hand surgery can make patients feel better. It will compare two groups: one that eats before surgery and one that fasts. Researchers will measure anxiety, nausea, and overall satisfaction to see if eating…

This study is testing if listening to music from a traditional Turkish flute called a ney can help people feel better after back surgery. Researchers will have 60 patients listen to 15-minute ney music sessions before and after their operation to see if it reduces their pain and …

This study is testing if wearable sensors can help spot early warning signs when a patient's health starts to decline after major surgery. Over 1300 patients in eight countries will wear chest and finger sensors for up to 10 days to record their heart rate and oxygen levels. The …

This study aims to compare two types of surgery for pancreatic and liver tumors: traditional open surgery and newer minimally invasive techniques. Researchers will look at the medical records of over 400 patients who had these surgeries between 2006 and 2020. They want to see whi…

This study aims to understand why some critically ill patients develop sudden kidney damage, especially after severe infections or major surgery. Researchers will measure inflammation markers in blood, urine, and sputum from 100 ICU patients with sepsis, recent surgery, or chemic…

This study aims to understand if robotic surgery is safe, effective, and worth the cost compared to traditional surgery. It will enroll 16,000 children and adults needing various operations to track complications, recovery, and expenses. The goal is to gather real-world evidence …

This study aims to find the best position to place a small temperature probe down the throat during surgery. Researchers will test different depths in 40 patients to see which gives the most accurate reading of the body's core temperature. The goal is to improve the safety and ac…

This study aims to grow miniature versions of liver tumors in the lab using patient tissue samples. Researchers will test how these mini-tumors respond to different cancer drugs and study how gut bacteria might affect treatment success. The goal is to better understand what makes…

This study aims to understand the long-term results of Achilles tendon repair surgery by following 5,000 patients for 20 years. It will track how many people re-injure their tendon, how well they return to sports and daily activities, and what complications occur over time. The g…

This study aims to understand if adding the nutrient arginine to the feeding of babies after major bowel surgery changes how their immune system genes work. Researchers will enroll 48 infants, giving some extra arginine and others standard nutrition, then track blood levels and g…

This study is checking if continuously monitoring oxygen levels while moving patients from the operating room to the recovery room helps catch and prevent low oxygen events. It will involve 30 adults having surgery under general anesthesia. Researchers will compare oxygen reading…

This study aims to understand how having COVID-19 affects recovery after surgery. Researchers will compare 300,000 surgical patients in Stockholm, looking at those with and without COVID-19. They'll track outcomes like hospital stays, complications, and recovery to help doctors p…

This study is testing whether giving doctors genetic information about patients helps them choose safer and more effective pain medications during and after surgery. Researchers are enrolling 1900 adults having elective surgery at the University of Chicago. They will compare outc…

This study is creating a registry to collect information on patients who have robotic-assisted 'keyhole' surgery in Europe. It aims to observe and document the safety and details of these procedures across several surgical specialties. The study does not test a new treatment but …

This study aims to understand when and why blood clots form in the veins around IV lines placed for major surgery. Researchers will use daily bedside ultrasound scans on 100 adult patients from when the IV is placed until it's removed to track clot formation. The goal is to ident…

This study aims to understand how modern, minimally invasive lung cancer surgery affects the heart. Researchers will closely monitor the heart's electrical activity and stress markers in 100 patients before, during, and after their surgery. The goal is to learn if these heart cha…

This study is testing whether patients with early-stage breast cancer can follow a special diet for about 9 days before their surgery. Researchers want to see if patients can stick to either a ketogenic (very low carb) or a protein-restricted diet. The main goal is to check if th…

This study looks back at the medical records of about 350 people whose cervical cancer returned or spread to a few new sites. Researchers want to understand which combinations of treatments—like chemotherapy, radiation, or surgery—led to the best survival and quality of life. The…

This study is testing a new system designed to help more older adults get a comprehensive health checkup before major surgery. It involves patients aged 80 and older who are scheduled for surgery, as well as their surgeons and other healthcare providers. The main goal is to see i…