SURGERY

This study tests whether using a connected scale at home can help people who had bariatric surgery avoid regaining too much weight. About 182 adults who had surgery one year ago will either get standard follow-up or also weigh themselves weekly with a smart scale. If the scale sh…

This study looks at whether adding surgery or radiation to a standard drug combination (palbociclib plus letrozole) can help people with newly diagnosed stage IV ER+/HER2- breast cancer live longer. About 200 women with cancer that has spread beyond the breast will receive the dr…

This study looks at how well the Insignia Hip Stem works and how safe it is for people needing a total hip replacement. It includes 313 adults with conditions like hip arthritis or fractures. Researchers will check implant survival and hip function for up to 10 years after surger…

This study tests whether briefly inflating a blood-pressure cuff on the arm before non-cardiac surgery can reduce heart damage in high-risk patients. Over 1,200 participants will receive either the cuff procedure or no intervention. The goal is to see if this simple, low-cost tec…

This study tests a structured nutrition plan for 300 ICU patients who had abdominal surgery and cannot eat normally. The plan includes IV nutrition, oral supplements, and a device to measure calorie needs. Researchers will track infections, ICU stay length, and muscle loss to see…

This trial compares two types of colon surgery for people with severe slow-transit constipation that hasn't improved with other treatments. About 252 adults will be randomly assigned to have either a total colectomy (removing the whole colon) or a subtotal colectomy (removing mos…

This study tests a new surgical technique called transanal total mesorectal excision (taTME) for rectal cancer. Instead of operating from the abdomen, surgeons work from the anus upward, which may make it easier to remove the tumor completely. The trial includes 100 adults with e…

This study compares two drugs, mannitol and nitroglycerin, given during robotic prostate or bladder surgery to prevent acute kidney injury. The surgery can reduce blood flow to the kidneys, and these drugs may help protect them. 90 adults with normal or mildly reduced kidney func…

This study tests whether using a lung ultrasound during robotic prostate or bladder surgery can help doctors set the breathing machine to the right pressure, reducing lung collapse and other breathing problems. 88 adults with mild or no lung disease are enrolled. The approach is …

This study compares two weight-loss surgeries for people with severe obesity (BMI over 45). One is the standard duodenal switch, and the other is a simpler version called SADI. Researchers track weight loss, health improvements like diabetes and high blood pressure, and complicat…

This study compares two surgical treatments for peri-implantitis, a serious gum infection around dental implants. Fifty-two adults will receive either a bone graft alone or a bone graft covered with a resorbable collagen membrane. The goal is to see which method better stops infe…

This phase 2 trial is testing whether taking the targeted drug lorlatinib for three months before surgery can shrink tumors in people with stage III ALK-positive non-small cell lung cancer. The study involves 48 participants and aims to see if the drug can eliminate all signs of …

This study is testing a new bone graft material called Induce XT in 60 people undergoing foot or ankle fusion surgery. The graft is made from processed human bone and is meant to help the bones heal together. Participants will be followed for 12 months with X-rays, CT scans, and …

This study tests whether special air purifiers in operating rooms can reduce serious infections after surgery. Over 66,000 patients having surgery lasting at least one hour are included. The air purifiers are either active or deactivated, and researchers track infections and comp…

This pilot study tests whether giving dexmedetomidine and lidocaine during major non-cardiac surgery can help patients recover faster and with less pain. About 100 adults having elective surgery will be randomly assigned to receive one of these drugs or standard care. The main go…

This study planned to test whether a nerve block in the cheek area could reduce the need for morphine after cleft palate repair in children aged 5 months to 12 years. The experimental group would have received the nerve block, while the control group would not. However, the study…

This study looks at two different ways to manage pain after lower back surgery without relying on drugs. About 267 adults will be randomly assigned to either standard care or an enriched pain management plan. The goal is to see which approach better reduces pain and helps people …

This study aimed to see if having a parent appear on a video call during anesthesia induction could reduce children's anxiety as effectively as the sedative midazolam. It was designed for children aged 4 to 8 undergoing outpatient surgery. However, the study was withdrawn before …

This study looks at whether playing music before or during hernia repair surgery can help lower pain after the operation. About 308 adults having surgery at Bethesda Surgery Center will take part. Researchers will measure pain scores and how much narcotic pain medicine is needed …

This study tests whether placing a colorful, washable walkway mat in front of children's beds can reduce pain and fear and help them start moving sooner after abdominal surgery. About 74 children aged 4–10 will be involved. The mat is designed to distract and encourage kids to wa…

This study looks at whether listening to music while getting up for the first time after abdominal surgery can lower pain and fear in children ages 4 to 6. Half the children will hear their chosen music during movement, while the other half gets standard care. Researchers will me…

This study tests a simple bedside exercise program called BE-FIT for adults aged 65 and older after surgery. The program encourages early movement and self-management to prevent muscle loss and speed up recovery. Researchers will compare mobility, hospital stay length, and compli…

This study aims to develop new tools that use machine learning to evaluate how well surgeons perform robotic surgery. Researchers will collect data from 1,000 surgeons across different specialties as they perform standard procedures. The goal is to find patterns that can help imp…

This study compares two devices that track muscle relaxation during robotic or laparoscopic surgery: acceleromyography (AMG) and electromyography (EMG). Researchers want to see if one method leads to using less rocuronium, a muscle relaxant. About 400 adults having elective surge…

This study looks at how the opioid remifentanil changes a person's pain threshold before surgery. Researchers will measure pain using a pressure device on the hand at different drug levels. The goal is to better understand how much opioid is needed, which could help personalize a…

This study compares two methods of training surgeons to have better conversations with patients about surgery risks and goals. About 60 surgeons and 660 patients will take part. One group of surgeons gets training from an education specialist, the other from a computer program. T…

This study tests a small sensor placed in reconstructed tissue after flap surgery. The sensor measures CO2 and temperature continuously for up to 10 days to detect early signs of poor blood flow. If it works, doctors could be alerted sooner and take action to save the tissue. Abo…

This study takes tissue that would normally be thrown away after surgery and uses it to grow cells in the lab. The goal is to develop better ways to study and repair tissues in the future. Up to 1,000 people having surgery at Wake Forest may participate. There is no direct benefi…

This study looks at how well children sleep before knee surgery and whether that affects their pain and need for painkillers afterward. Researchers will ask kids about their sleep and track their pain and opioid use for two weeks after surgery. They will also use smart pill bottl…

This study aimed to see if switching from isoflurane to desflurane during surgery could help adults wake up faster and leave the hospital sooner. It was planned for adults having general anesthesia, but the study was withdrawn before any participants were enrolled. No results are…

This study looks at how to improve the pre-surgery checkup process for older adults having major abdominal surgery. Researchers will observe clinic visits and interview patients, caregivers, and healthcare providers to find what works well and what could be better. The goal is to…

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This pilot study at Massachusetts General Hospital tests whether allowing a slightly lower blood pressure (MAP above 60 mmHg) after heart surgery is safe and reduces the need for blood-pressure-raising drugs. 80 adults having elective heart surgery are randomly assigned to either…

This study looks at whether a program of computer brain games and supervised physical exercise, done before and after surgery, can help older adults (60+) keep their thinking skills and physical abilities. 250 people having major non-cardiac surgery will be randomly assigned to e…

This study uses a non-invasive surface EMG device (sensor stickers on the skin) to measure how well regional anesthesia (nerve blocks) works during surgery in children and young adults up to age 21. The goal is to learn how to give nerve blocks more safely and effectively. Partic…

This study was designed to see if the amount of air set on a breathing machine during children's surgery matches the actual air moving in and out of the lungs. Researchers planned to use a small sensor to measure airflow and compare it to the machine's settings. However, the stud…

This study looks at blood samples from 84 children aged 4-17 having their tonsils removed to find chemical clues about why Black children often report more pain afterward. Researchers will measure pain scores and compare blood metabolites between racial groups. The goal is to und…

This study looks at how two types of weight-loss surgery affect bone health in teenagers and young adults aged 13-21. Researchers will measure changes in bone density and strength over two years in 240 participants, comparing those who had surgery with those who did not. The goal…

This study was designed to see if a short-term protein-calorie restriction diet before elective vein graft surgery is practical and how it affects the body. It planned to enroll adults scheduled for non-emergency lower extremity vein bypass surgery. However, the trial was withdra…