New drug shrinks lung tumors before surgery in early trial

NCT ID NCT05740943

First seen Jan 06, 2026 · Last updated May 16, 2026 · Updated 21 times

Summary

This study tests whether the drug lorlatinib can shrink tumors in people with a specific type of stage III lung cancer (ALK-positive) before they have surgery. About 48 adults will take lorlatinib for a set time, then doctors will check if the tumor is gone or much smaller. The goal is to see if this approach helps control the disease and guides next steps.

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Contacts and locations

Locations

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, 510080, China

  • Guangzhou Twelfth People's Hospital

    Guangzhou, Guangdong, China

  • Peking Union Medical College Hospital

    Beijin, Beijin, 100730, China

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan, 410011, China

Conditions

Explore the condition pages connected to this study.