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Arm cuff before surgery may shield heart, trial suggests

NCT ID NCT02427867

Ongoing Disease control Sponsor: Università Vita-Salute San Raffaele Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether briefly inflating a blood-pressure cuff on the arm before non-cardiac surgery can reduce heart damage in high-risk patients. Over 1,200 participants will receive either the cuff procedure or no intervention. The goal is to see if this simple, low-cost technique lowers cardiac troponin levels, a marker of heart injury.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
remote ischemic preconditioning (blood-pressure cuff inflation on the arm)
What this could lead to
If it works, this could offer a safe, low-cost way to prevent heart complications during non-cardiac surgery.
What could go wrong
This is the first large trial in non-cardiac surgery, so results are uncertain. The effect may be smaller than hoped or not translate to better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOCARDIAL ISCHEMIA SURGERY

Contacts and locations

Locations

  • A.O.U. Pisana

    Pisa, Italy

  • Astana Medical University

    Astana, 010000, Kazakhstan

  • Azienda Ospedaliero Universitaria Careggi

    Florence, 50139, Italy

  • Azienda Sanitaria Universitaria Friuli Centrale "Santa Maria della Misericordia"

    Udine, 33100, Italy

  • Azienda Universitaria Ospedaliero Pisana

    Pisa, 56100, Italy

  • E.O. Ospedali Galliera

    Genova, 16128, Italy

  • Fondazione IRCCS. Istituto Neurologico Carlo Besta

    Milan, 20133, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    Rome, 00136, Italy

  • Fondazione Policlinico Universitario Campus Bio-Medico di Roma

    Rome, 00128, Italy

  • Fundación Cardioinfantil-Instituto de Cardiología

    Bogotá, 110131, Colombia

  • Humanitas Clinical Institute

    Rozzano, Lombardy, 20100, Italy

  • I.M. Sechenov First Moscow State Medical

    Moscow, Russia

  • IRCCS San Raffaele Scientific Institute

    Milan, 20132, Italy

  • Institute of Cardiovascular Diseases "Dedinje"

    Belgrade, Serbia

  • Loginov Moscow Clinical Scientific Center

    Moscow, 111123, Russia

  • National University Hospital

    Singapore, 119074, Singapore

  • Oncological Center No. 1 of the S. S. Yudin City Clinical Hospital of the Moscow Department of Health

    Moscow, 117152, Russia

  • Ospedale Cardinal Massaia

    Asti, 14100, Italy

  • Ospedale Regionale di Lugano

    Lugano, Switzerland

  • Saint-Petersburg State University Hospital

    Saint Petersburg, Russia

  • ULSS 4 Veneto Orientale, Ospedale di San Donà di Piave

    San Donà di Piave, 30027, Italy

  • University Hospital Centre Zagreb

    Zagreb, 10000, Croatia

  • Università degli studi della Campania Luigi Vanvitelli

    Naples, 80138, Italy

  • V.Negovsky Reanimatolgy Research Institute

    Moscow, Russia

  • Valle Olona Po hospital

    Busto Arsizio, Varese, Italy

  • Xijing Hospital

    Xi'an, 710032, China

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