Arm cuff before surgery may shield heart, trial suggests
NCT ID NCT02427867
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether briefly inflating a blood-pressure cuff on the arm before non-cardiac surgery can reduce heart damage in high-risk patients. Over 1,200 participants will receive either the cuff procedure or no intervention. The goal is to see if this simple, low-cost technique lowers cardiac troponin levels, a marker of heart injury.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
remote ischemic preconditioning (blood-pressure cuff inflation on the arm)
What this could lead to
If it works, this could offer a safe, low-cost way to prevent heart complications during non-cardiac surgery.
What could go wrong
This is the first large trial in non-cardiac surgery, so results are uncertain. The effect may be smaller than hoped or not translate to better outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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A.O.U. Pisana
Pisa, Italy
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Astana Medical University
Astana, 010000, Kazakhstan
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Azienda Ospedaliero Universitaria Careggi
Florence, 50139, Italy
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Azienda Sanitaria Universitaria Friuli Centrale "Santa Maria della Misericordia"
Udine, 33100, Italy
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Azienda Universitaria Ospedaliero Pisana
Pisa, 56100, Italy
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E.O. Ospedali Galliera
Genova, 16128, Italy
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Fondazione IRCCS. Istituto Neurologico Carlo Besta
Milan, 20133, Italy
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, 00136, Italy
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Fondazione Policlinico Universitario Campus Bio-Medico di Roma
Rome, 00128, Italy
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Fundación Cardioinfantil-Instituto de Cardiología
Bogotá, 110131, Colombia
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Humanitas Clinical Institute
Rozzano, Lombardy, 20100, Italy
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I.M. Sechenov First Moscow State Medical
Moscow, Russia
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IRCCS San Raffaele Scientific Institute
Milan, 20132, Italy
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Institute of Cardiovascular Diseases "Dedinje"
Belgrade, Serbia
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Loginov Moscow Clinical Scientific Center
Moscow, 111123, Russia
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National University Hospital
Singapore, 119074, Singapore
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Oncological Center No. 1 of the S. S. Yudin City Clinical Hospital of the Moscow Department of Health
Moscow, 117152, Russia
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Ospedale Cardinal Massaia
Asti, 14100, Italy
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Ospedale Regionale di Lugano
Lugano, Switzerland
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Saint-Petersburg State University Hospital
Saint Petersburg, Russia
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ULSS 4 Veneto Orientale, Ospedale di San Donà di Piave
San Donà di Piave, 30027, Italy
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University Hospital Centre Zagreb
Zagreb, 10000, Croatia
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Università degli studi della Campania Luigi Vanvitelli
Naples, 80138, Italy
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V.Negovsky Reanimatolgy Research Institute
Moscow, Russia
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Valle Olona Po hospital
Busto Arsizio, Varese, Italy
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Xijing Hospital
Xi'an, 710032, China