SURGERY

This study looks at 100 adults with liver cancer that was initially too advanced for surgery but improved after conversion therapy. Researchers want to see if having surgery or continuing maintenance therapy is better at preventing the cancer from coming back. The goal is to help…

This study tests whether adding the immunotherapy drug adebrelimab, with or without the targeted drug apatinib, to standard chemotherapy (SOX) can shrink advanced stomach cancer before surgery. About 118 adults with HER2-negative stomach cancer that cannot be removed right away w…

This study looks at people with stage II-IIIB non-small cell lung cancer whose tumors shrank after immunotherapy. It compares two surgery approaches: removing less lung tissue (to preserve lung function) versus the standard larger removal. The goal is to see if the smaller surger…

This study looks at whether giving older adults (65-90) a combination of two medicines (dexmedetomidine and esketamine) along with a gentle brain stimulation technique (tDCS) during and after surgery can prevent long-term memory and thinking problems. The researchers will follow …

This study tests whether giving older adults (65-90 years) a combination of two medicines (dexmedetomidine and esketamine) along with a gentle brain stimulation technique (tDCS) before and after surgery can prevent confusion and memory problems. About 1,160 participants will be f…

This study tests whether using nerve monitoring and a gentle electric tool during armpit lymph node removal can help surgeons find and protect small nerves that often cause long-term pain after breast cancer surgery. Six adults with breast cancer will take part. The goal is to se…

This study tests whether adding intravenous lidocaine to standard spinal morphine can lower the amount of morphine needed after major abdominal surgery. About 76 adults having planned open abdominal surgery will receive either lidocaine or a placebo. The goal is to see if lidocai…

This study compares adding two different steroids to the standard pain injection given during total knee replacement surgery. The goal is to see which option reduces pain, lowers the need for opioid painkillers, and improves knee movement and recovery. About 240 adults with sever…

This study focuses on helping patients with low health literacy—those who struggle to understand medical information—recover better after surgery. Researchers will test a program called VISACT that uses visual aids, coaches providers in clear communication, and trains hospitals t…

This study will use a special monitor to measure how nerves and muscles communicate in infants under 3 months old compared to older patients (12 years and up) during surgery. The goal is to learn about differences in nerve-muscle signals, which could help doctors provide safer ca…

This study looks at how much the tensor fascia latae (TFL) muscle is damaged during hip replacement surgery through the front of the hip. Researchers want to see if more damage leads to worse recovery in the first 6 months. 150 adults getting their first hip replacement will be f…

This study tests whether using a wearable sensor that continuously tracks heart rate, breathing, and oxygen levels after surgery can catch problems earlier than the usual periodic checks by nurses. About 522 adults having major non-cardiac surgery will be randomly assigned to eit…

This pilot study looks at whether letting patients eat a regular diet right after colon removal surgery is safe and might help them feel better. Ten adults having colon surgery will be followed for 30 days to see if this approach reduces hospital readmissions and improves quality…

This study looks at how different depths of anesthesia affect thinking and memory recovery in older adults (65+) after non-heart surgery. Researchers will use a fixed ratio of two common anesthetics to see if a specific depth reduces confusion or memory loss. 200 participants wil…

This study will use ultrasound to measure the size of two arteries in each arm of 100 children having surgery. The goal is to see if the dominant hand (right or left) has larger arteries. This is an observational study only, with no treatment or intervention.

This study looks at 200 people with Charcot-Marie-Tooth disease (CMT) who have foot problems that make walking hard. It compares two treatments: foot surgery followed by rehabilitation, versus physical therapy alone. Researchers will track walking speed and endurance for up to tw…

This study will check if pulse oximeters, which measure oxygen levels, work equally well in dark-skinned (Black) and light-skinned (White) children aged 2-9 during surgery. Researchers will compare the device's readings to a more precise blood test. The goal is to see if skin col…

This study tests whether a wearable device called MultiSense® can safely monitor elderly patients (65+) at home after major surgery. The goal is to see if it reduces hospital stays and prevents emergency visits. Eighty participants will use the device after going home, and resear…

This study looks at two ways of giving fluids during liver surgery: one that limits fluids and one that gives more. The goal is to see which approach leads to fewer serious problems after surgery, especially kidney injury. About 90 adults having planned liver surgery will take pa…

This study tests whether an artificial intelligence virtual assistant (AIVA) can help plastic surgery patients by reducing the number and length of phone calls to the clinic. Researchers will track phone calls and satisfaction among 200 adult patients at Mayo Clinic Florida. The …

This study will use a device called TetraGraph to track how quickly the muscle relaxant rocuronium takes effect and wears off in 130 surgery patients. The goal is to find the exact timing for safer breathing tube placement. Participants will be monitored during their procedure, a…