SURGERY

This trial tests whether a structured follow-up program after surgery can reduce the number of people still using opioids 90 days later. The program uses patient-reported recovery scores to guide care, with nurses and community providers working together. About 772 adults having …

This study tests whether adding a special type of radiation (SF-SBRT) to the usual combination of immunotherapy (toripalimab) and chemotherapy helps people with stage II-III non-small cell lung cancer live longer without the cancer coming back. About 200 participants will be rand…

This study looks at 100 liver cancer patients whose tumors shrank or disappeared after initial therapy. It compares two follow-up options: surgery to remove any remaining cancer, or continuing medication (maintenance therapy). The goal is to see which approach better prevents the…

This study looks at whether a smaller lung surgery after immunotherapy works as well as the standard larger surgery for people with stage II-IIIB non-small cell lung cancer. About 354 patients whose tumors shrank with immunotherapy will choose either a limited or conventional sur…

This Phase 3 trial tests whether adding an immunotherapy drug (adebrelimab) and a targeted therapy (apatinib) to standard chemotherapy (SOX) can improve outcomes for people with locally advanced stomach cancer that cannot be removed right away. The study will enroll 118 participa…

This long-term study follows older adults (65-90) who are having non-cardiac surgery to see if a combination of two drugs (dexmedetomidine and esketamine) plus a gentle brain stimulation technique (tDCS) can prevent memory and thinking problems that sometimes occur after surgery.…

This study tests two approaches—a combination of medicines (dexmedetomidine and esketamine) and a gentle brain stimulation technique (tDCS)—to prevent confusion and memory problems after surgery in older adults. About 1,160 patients aged 65-90 with mild cognitive issues will be e…

This study tests whether giving lidocaine through an IV, along with a spinal morphine injection, can lower the amount of morphine patients need after major digestive or abdominal surgery. About 76 adults having planned open abdominal surgery will be randomly assigned to receive e…

This study explores whether a personalized music therapy session, called music-assisted relaxation and imagery (MARI), can reduce pain and change gene activity in people recovering from open surgery for stomach, pancreas, bile duct, liver, or peritoneal cancer. Participants will …

This study tests whether Shouhui Tongbian Capsules, a traditional Chinese herbal medicine, can relieve constipation after surgery for benign anal or rectal conditions like hemorrhoids. 120 adults will be randomly assigned to take either the herbal capsules or a standard laxative …

This study will give 200 plastic surgery patients access to an artificial intelligence virtual assistant called AIVA. The assistant answers questions about their upcoming surgery. Researchers want to see if this reduces phone calls to clinic staff and improves patient and provide…

This study tests whether adding a steroid to the standard pain injection during total knee replacement improves pain control and reduces the need for opioid painkillers. 240 adults undergoing knee replacement will be randomly assigned to receive either the standard injection, one…

This study tests a communication tool called the FOCUS Guide. It is designed to help older adults (age 65 and up) and their surgeons talk about the goal of surgery during clinic visits. The study will see if using the guide leads to more discussions and documentation of surgery g…

This study will test whether continuously monitoring vital signs like oxygen levels and heart rate after major surgery can reduce complications compared to standard intermittent checks. About 492 adults having non-cardiac surgery will be randomly assigned to either have their dat…

This observational study will use ultrasound to measure the size of two arteries in the arms of 100 children undergoing surgery. The goal is to see if the dominant hand has larger arteries than the non-dominant hand. The findings could help guide medical procedures like placing I…

This study compares nerve-muscle communication in infants (under 3 months) and older patients (12+ years) during surgery. Using a special monitor called TetraGraph™, researchers will measure muscle responses to electrical signals. The goal is to understand how these signals diffe…

This study looks at how deep anesthesia affects memory and thinking in older adults (65+) after non-heart surgery. Researchers will give a fixed mix of two anesthetic drugs to 200 participants and check their brain function with a simple test. The goal is to find the best anesthe…

This study will test a device called TetraGraph that measures muscle response to electrical stimulation. It will track how quickly the muscle relaxant rocuronium takes effect and wears off in 130 children having surgery. The goal is to help doctors know the best time to place a b…

This study looks at two ways of giving fluids during liver surgery: one that limits fluids and one that gives more. The goal is to see which approach leads to fewer serious problems after surgery, especially kidney injury. About 90 adults having planned liver surgery will take pa…

This study looks at two ways to help people with Charcot-Marie-Tooth disease (CMT) walk better. One group gets foot surgery followed by rehabilitation, the other gets only physical therapy. Researchers will track walking speed and endurance for up to two years to see which approa…

This study will check if pulse oximeters, which measure oxygen levels in the blood, are as accurate in dark-skinned children as in lighter-skinned children. About 540 children aged 2-9 undergoing anesthesia will have their pulse oximeter readings compared to a more precise blood …

This study examines how much the tensor fascia latae muscle is damaged during hip replacement surgery through the front approach. Researchers will compare the amount of muscle damage to how well patients recover at 6 weeks and 6 months. The goal is to understand if less muscle da…