Thrombotic disease

This trial tests a device called the Symphony Thrombectomy System in people with acute pulmonary embolism, a condition where blood clots block arteries in the lungs. The device is designed to restore blood flow by suctioning out or breaking up the clots. The study will check how …

This trial tests whether giving the sedative dexmedetomidine during and after reconstructive microsurgery can help transplanted tissue (flaps) survive better in cancer patients. The study will compare flap health at 48 hours after surgery in patients receiving dexmedetomidine ver…

This completed Phase 4 trial studied 60 people with peripheral artery disease (PAD) to see if adding low-dose rivaroxaban to aspirin improves blood vessel function and reduces clotting. Participants took either rivaroxaban plus aspirin or a placebo plus aspirin. The study measure…

This early-stage trial tested a single injection of a new drug called SRSD107 in 48 healthy adults. The drug is designed to temporarily lower a clotting factor in the liver, potentially preventing dangerous blood clots with less bleeding risk than standard treatments. The main go…

This study tested whether ticagrelor, a newer antiplatelet drug, reduces heart muscle damage during a procedure called rotational atherectomy, which clears hardened arteries. 180 stable heart patients received either ticagrelor or standard clopidogrel before and after the procedu…

This study tested a combination of proton beam radiotherapy followed by two drugs (Tecentriq and Avastin) in 63 adults with advanced liver cancer that had spread into the portal vein. The goal was to see if this approach could help control the cancer and improve survival. Partici…

This study tested whether a special blood test (ROTEM) can better guide blood transfusions in people with acute-on-chronic liver failure who are bleeding from enlarged veins. 262 participants were randomly assigned to receive transfusions based on either the new test or standard …

This study tested a three-drug combination for people with advanced liver cancer that has spread into the portal vein (a major blood vessel). The treatment adds a liver-directed chemotherapy infusion to two standard drugs (lenvatinib and a PD-1 inhibitor). The goal was to see if …

This study looked at how well the drug argatroban works in 20 adults with a condition called heparin-induced thrombocytopenia Type II, where the blood thinner heparin causes low platelets and raises clot risk. Participants received argatroban to prevent new or worsening blood clo…

This study tested a new way to prevent blood clots in the dialysis machine without using heparin, a blood thinner that can cause dangerous bleeding. The method uses a special fluid with citrate and no calcium, and adds calcium back into the body as needed. The study included 97 c…

This study looked at 345 people with a severe stroke caused by a blockage in the basilar artery, a major blood vessel in the brain. It compared two treatments: giving a clot-busting drug followed by a procedure to remove the clot, versus doing the procedure alone. The goal was to…

This study looked at whether using a person's genetic information to choose their blood-thinning medication (clopidogrel or an alternative) leads to better outcomes after a heart procedure. 283 adults with chronic coronary artery disease who had a stent placed were split into two…

This study tested a new way to treat severe blood clots in the portal vein during liver transplant surgery. Doctors used a special approach through a ligament in the donor liver to place stents or close off abnormal veins. The study included 75 patients and found the method safe …

This study tested a stent retriever device, already used for strokes, to remove clots during heart attacks. The goal was to reduce damage to small heart blood vessels caused by clot fragments. 81 patients with severe heart attacks were enrolled to see if the device works better t…

This study tested a new diagnostic tool that uses imaging flow cytometry to examine platelets in blood samples. Researchers compared it to standard lab tests in 31 patients suspected of having platelet disorders or heparin-induced thrombocytopenia. The goal was to see if the new …

This study tested whether a simple scoring system (ATE score) can safely rule out dangerous blood clots in the heart before a procedure for atrial fibrillation. Over 3,000 adults participated. The goal was to see if the score could replace a more uncomfortable ultrasound test, po…

This study combined data from nearly 4,000 stroke patients to see how often a heart CT scan finds blood clots that standard ultrasound might miss. Researchers looked at how well this quick scan, done during the initial stroke workup, detects clot sources in the heart. The goal is…

This study tested a new device called Quantra QStat that measures how well blood clots, compared to standard lab tests. It involved 296 pregnant women or new mothers at risk of heavy bleeding during delivery. The goal was to see if the new device gives faster and reliable results…

This study tested whether an ultrasound of the optic nerve sheath (the lining around the nerve connecting the eye to the brain) can accurately detect dangerously high pressure inside the skull in children. Researchers measured the nerve sheath diameter in 230 children with brain …

This trial tests whether a short 5-day course of the blood thinners rivaroxaban (Xarelto) or apixaban (Eliquis) can prevent blood clots that sometimes form after laser treatment for varicose veins. Adults with symptomatic vein reflux undergoing laser ablation of the great sapheno…

This study tested whether using a device that electrically stimulates arm muscles can prevent blood clots caused by PICC catheters in critically ill patients. 120 adults in intensive care units were randomly assigned to receive either standard care or standard care plus two daily…

This completed study looked at whether a drug called Dimolegin can safely prevent blood clots in adults hospitalized with moderate COVID-19. A total of 184 participants took a 60 mg tablet once daily as part of their regular care. The main goal was to check for serious bleeding a…

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This study looked at placing a small metal tube (stent) into the portal vein of 63 cancer patients whose vein was blocked by a tumor. The goal was to relieve serious symptoms like fluid buildup in the belly or bleeding in the gut. The procedure was done through a needle in the li…

This study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…

This study looked at how doctors make decisions about dosing the blood thinner warfarin based on a patient's genetic background. Researchers used virtual reality to simulate patient visits with different racial and socioeconomic backgrounds. 196 internal medicine residents partic…

This trial investigates whether genetic variations in the CES1 gene influence how the body responds to the blood thinners clopidogrel and aspirin. Healthy Amish adults will take clopidogrel for a week, then a single dose of aspirin, with blood tests measuring platelet function be…

This trial compares spinal anesthesia (using bupivacaine) with general anesthesia in men undergoing transurethral resection of the prostate (TURP) for benign prostatic hyperplasia. Researchers measure blood clotting and breakdown markers before surgery and at 1 and 24 hours after…

This trial investigates whether a common genetic variation in the CES1 gene affects how the body processes two antiplatelet drugs, clopidogrel and ticagrelor. Healthy volunteers of Amish descent will take each drug for eight days in a crossover design, and researchers will measur…

This pilot study investigates whether certain blood markers (DIC markers and thrombin generation parameters) can predict thrombotic and hemorrhagic complications in adults on ECMO life support. Researchers will observe these markers in patients with and without complications. The…

This study looks at how well existing risk models predict dangerous blood clots in people with diffuse large B-cell lymphoma (DLBCL), a common type of blood cancer. Researchers will review medical records from over 1,500 patients across multiple hospitals to see which factors are…

This study looked at whether a quick bedside test (Hemochron Jr) gives the same results as standard lab tests for measuring blood clotting in people having planned heart bypass surgery. Twenty patients were tested before and after being placed on a heart-lung machine. The goal wa…

This early-stage study tested a new drug called Vitalangio1 in 627 healthy adults aged 18–55 to see if it is safe and how the body processes it. Participants took either the drug or a placebo, and some took it with or without food to see how that affects absorption. The study doe…

This study looked at 70 people who had a tissue heart valve replacement. It compared two common blood-thinning treatments (high-dose aspirin alone vs warfarin plus low-dose aspirin) to see which one better prevented tiny blood clots from traveling to the brain. Researchers used u…

This study looked at 232 people with cerebral venous thrombosis, a rare stroke that mainly affects young women. Researchers took blood samples at several time points to measure markers of clot formation and breakdown. They wanted to see if these markers relate to how the disease …

This completed study followed 550 people who had a stroke within the last 48 hours. Researchers wanted to understand why some patients recover better than others by looking at their medical history, lifestyle, and blood markers. The goal is to find out what factors protect the br…

This study examined how the Impella heart pump changes platelet function in 30 patients with cardiogenic shock or cardiac arrest. Researchers measured markers of platelet activation and aggregation before and during pump support. The goal was to understand why some patients devel…

This study tested whether a computer program (Simcyp) could help doctors choose the right starting dose of warfarin, a blood thinner, for 21 patients with liver cirrhosis and a blood clot in the portal vein. The goal was to see if the program helped patients reach a safe, effecti…

This completed study tested whether sotagliflozin, a dual SGLT1/2 inhibitor, reduces blood clot formation better than empagliflozin, a standard SGLT2 inhibitor. Seventeen healthy volunteers took each drug for one month in a crossover design. Researchers measured clot size and pla…

This study looked at how often blood clots form soon after placing a central venous catheter (a special IV line) in children in the pediatric intensive care unit. Researchers used ultrasound to scan for clots 1 to 13 days after placement. The goal was to better understand the tim…

This study looked at 100 people who recently had a major heart attack to better understand blood clots that can form in the heart's main pumping chamber. Using special PET/MR scans, researchers tracked clot activity in the heart and brain over several months. The goal was to lear…

This completed observational study looked at how intravenous lipid emulsions (fat-containing nutrition given through a vein) affect blood clotting in 6,259 hospitalized patients. Researchers compared clotting tests before and after patients received these emulsions as part of rou…

This small pilot study explored whether advanced heart imaging can detect hidden strokes in people who have never had atrial fibrillation but are at high risk due to conditions like diabetes or heart failure. Researchers used brain MRIs to find silent, symptom-free strokes and li…

This study examined blood clotting in 57 people with Congenital Disorder of Glycosylation (CDG), a rare genetic condition. Researchers used a special test called the thrombin generation assay to see if the body's clotting system stays balanced despite having low levels of both cl…

This study looked at whether measuring immature platelets in the blood can help predict how septic shock patients will fare. Researchers followed 196 intensive care patients and checked if the immature platelet fraction at admission was linked to death or organ failure at 28 days…

This study interviewed 15 children aged 12 to 21 who have bleeding or clotting disorders. Researchers asked about their quality of life, confidence in managing their condition, and how they view the care they receive. The goal is to better understand the real-life challenges thes…

This study looked at 757 adult patients treated for COVID-19 at Lille University Hospital to find out which factors best predict death within 28 days. Researchers collected medical, lab, and imaging data to understand why some patients die and others recover. The goal is to help …

This study tested a decision-support tool called DOACT that helps doctors choose the right blood thinner for patients with blood clots in veins or lungs. Researchers compared how well the tool performed against artificial intelligence models and doctors' own judgment. The goal wa…

This completed study looked at blood clotting in 175 hospitalized COVID-19 patients. Researchers used a special test to measure how quickly and strongly blood clots form, and whether a protein called thrombomodulin can slow this process. The goal was to understand why some COVID-…

This study looked at brain MRI scans of 122 stroke patients to see if those with a blood clot in the heart (intracardiac thrombus) had different patterns of brain damage compared to those with atrial fibrillation. Researchers analyzed the location, size, and number of stroke lesi…

This study tested whether using a softer, more flexible catheter material reduces irritation and failure of intravenous lines. Twenty-seven healthy adults each received two catheters (one standard, one more flexible) in opposite arms for up to 72 hours. Researchers measured cathe…

This study involved 150 people with completely blocked heart arteries who had a special procedure called STAR. Researchers wanted to find the best time to place a stent afterward—either 5-7 weeks or 12-14 weeks later. The goal was to see which timing leads to a more successful st…

This study looked at 700 cancer patients to understand how often dangerous blood clots occur and how blood-thinning medications affect them. Researchers tracked patients over two years, analyzing blood samples and clotting events. The goal is to improve prevention and treatment o…

This completed study looked at 11,000 COVID-19 patients to understand how often they develop dangerous blood clots in arteries or veins. Researchers tracked clot rates, risk factors, and outcomes over 30 and 90 days. The goal was to learn more about these complications to improve…

This completed study looked at 552 adults with myeloproliferative neoplasms (MPN) who also had COVID-19. Researchers wanted to see how often these patients developed blood clots, like pulmonary embolism. The goal was to understand what factors make COVID-19 worse for people with …

This completed study looked at 258 people with different types of cardiomyopathy (a disease of the heart muscle) to see if special imaging could predict stroke risk. Researchers used echocardiograms and MRI scans to measure blood flow in the heart and check for silent brain infar…

This completed study looked at whether removing extra water from the blood just before taking patients off the heart-lung machine could improve blood clotting. It included 39 adults having heart valve surgery. The researchers measured changes in clot strength using a special bloo…

This study tracked 81 adults with pelvic or hip socket fractures to see how often they developed blood clots in their legs or lungs, even while receiving standard clot-preventing medication. All participants got ultrasound scans to find clots that might not cause symptoms. The go…