New blood thinner may shield heart during artery procedure

NCT ID NCT02505399

Completed Disease control Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether ticagrelor, a newer antiplatelet drug, reduces heart muscle damage during a procedure called rotational atherectomy, which clears hardened arteries. 180 stable heart patients received either ticagrelor or standard clopidogrel before and after the procedure. Researchers measured troponin levels to see if ticagrelor better prevents tiny blood clots and debris from harming the heart.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ticagrelor
What this could lead to: If it works, this could show that ticagrelor better protects the heart during artery-clearing procedures, potentially reducing complications.
What could go wrong: This is a small, completed Phase 4 trial with 180 patients, so results may not apply broadly. Ticagrelor also carries a higher bleeding risk than clopidogrel.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis coronary atherosclerosis thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROSIS

Contacts and locations

Locations

Clinique Pasteur

Toulouse, Haute-Garonne, 31000, France
Fédération de Cardiologie CHU TOULOUSE

Toulouse, Haute-Garonne, 31059, France
Hospices civils de Lyon

Lyon, 69000, France
University Hospital

Nîmes, 30000, France

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