Heart valve study: which blood thinner best protects the brain?

NCT ID NCT00465218

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looked at 70 people who had a tissue heart valve replacement. It compared two common blood-thinning treatments (high-dose aspirin alone vs warfarin plus low-dose aspirin) to see which one better prevented tiny blood clots from traveling to the brain. Researchers used ultrasound to detect these clots and also measured how well the treatments affected platelet function.

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Conditions

The condition(s) this trial relates to.

Aortic Valve Disease aortic valve disorder intracranial embolism thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Ottawa Heart Institute

    Ottawa, Ontario, K1Y 4W7, Canada