Could a lower warfarin dose make aortic valve replacement safer?

NCT ID NCT02677974

Ongoing Disease control Sponsor: On-X Life Technologies, Inc. Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study looks at whether people with an On-X mechanical aortic heart valve can safely take a lower dose of the blood thinner warfarin. The goal is to reduce bleeding complications while still preventing dangerous blood clots. Researchers will follow 510 adults for up to 5 years after valve replacement surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: On-X Aortic Heart Valve replacement with low dose warfarin
What this could lead to: If successful, this could show that a lower warfarin dose safely reduces bleeding risk while still preventing clots in people with an On-X aortic valve.
What could go wrong: This is an observational registry, not a randomized trial, so results may be influenced by patient differences. Lower warfarin doses might increase the risk of valve clots or strokes in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THROMBOTIC AND BLEEDING EVENTS

Contacts and locations

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Locations

Arizona Cardiothoracic & Neurology

Tucson, Arizona, 85718, United States
Baylor Scott & White - Plano

Plano, Texas, 75093, United States
Blackpool Victoria Hospital

Blackpool, United Kingdom
Carilion Clinic

Roanoke, Virginia, 24014, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Franciscan St. Francis

Indianapolis, Indiana, 46237, United States
Hartford Hospital

Hartford, Connecticut, 06102, United States
Hull & East Yorkshire Hospitals

Hull, United Kingdom
John Radcliffe Hospital

Oxford, United Kingdom
Maine Medical Center

Portland, Maine, 04102, United States
MultiCare Health System

Tacoma, Washington, 98405, United States
Providence St. Vincent

Portland, Oregon, 97213, United States
Sanford Medical Center

Fargo, North Dakota, 58122, United States
Sentara Norfolk General Hospital

Norfolk, Virginia, 23507, United States
St. Bartholomew's Hospital

London, EC1A 7BE, United Kingdom
Swedish Medical Center

Seattle, Washington, 98122, United States
The Lindner Center at The Christ Hospital

Cincinnati, Ohio, 45219, United States
University Hospital Southampton

Southampton, SO16 6YD, United Kingdom
University of Calgary

Calgary, Alberta, Canada
University of Ottawa Heart Institute

Ottawa, Ontario, K1Y 4W7, Canada
University of Texas Health Science Center - Houston

Houston, Texas, 77030, United States
University of Texas Southwestern

Dallas, Texas, 75390, United States
Victoria Heart Institute

Victoria, British Columbia, Canada

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