New antibody drugs aim to prevent deadly clots in PAD patients after leg surgery
NCT ID NCT07318610
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial is testing two experimental drugs, REGN7508 and REGN9933, to prevent serious blood clots in people with peripheral artery disease who recently had leg surgery to improve blood flow. The study will enroll about 7,050 participants and compare the drugs to a placebo and the standard blood thinner rivaroxaban. The goal is to see if these antibodies can reduce the risk of life-threatening events like limb loss, heart attack, or stroke.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
REGN7508 (cenvacibart) and REGN9933 (amrecibart), monoclonal antibodies targeting factor XI
What this could lead to
If successful, these drugs could offer a new way to prevent life-threatening blood clots in people with peripheral artery disease after leg surgery, potentially with fewer bleeding risks than current treatments.
What could go wrong
This is a large phase 3 trial, but the drugs are still experimental. They may not work better than existing options, and side effects or unexpected bleeding risks could emerge.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Epic Medical Research
RECRUITINGDeSoto, Texas, 75115, United States
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Epic Medical Research-Plano
RECRUITINGPlano, Texas, 75093, United States
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Nature Coast Clinical Research - Cardiology
RECRUITINGCrystal River, Florida, 34429, United States
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PharmaTex Research
RECRUITINGAmarillo, Texas, 79106, United States