New pill aims to tame chaotic heartbeats in atrial fibrillation

NCT ID NCT07267949

Recruiting now Disease control Sponsor: Acesion Pharma Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether the experimental drug AP31969 can reduce the amount of time people with atrial fibrillation spend in an irregular heart rhythm. Two hundred adults with paroxysmal or persistent AF will receive either AP31969 or a placebo twice daily for several weeks. The main goal is to see if the drug lowers AF burden, measured by a heart monitor, and improves quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AP31969 (oral tablet)
What this could lead to: If successful, this could provide a new oral medication to better control atrial fibrillation and improve quality of life for patients.
What could go wrong: This is an early Phase 2 trial with only 200 participants, so results may not confirm effectiveness or safety. The drug may not reduce AF burden more than placebo.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION (AF)

Contacts and locations

Locations

ASST Grande Ospedale Metropolitano Niguarda Cardiology 3 - Electrophysiology "De Gasperis" Cardio Center
RECRUITING

Milan, 20162, Italy
Acibadem City Clinic, Cardiology Department
RECRUITING

Sofia, SOF, 1000, Bulgaria
Aleksandrovska University Hospital, Clinic of Cardiology
RECRUITING

Sofia, SOF, 1431, Bulgaria
Arcispedale Sant'Anna, Cardiology Department
RECRUITING

Cona, FE, 444124, Italy
Belvárosi Egészségház, Platán Magánklinika
RECRUITING

Zalaegerszeg, 8900, Hungary
Budai Irgalmasrendi Kórház
RECRUITING

Budapest, 1023, Hungary
Centrum Medyczne KERmed Cardiology Department
RECRUITING

Bydgoszcz, 85-231, Poland
Dell'Angelo Hospital, Cardiology Department
RECRUITING

Mestre, VE, 30174, Italy
Deventer Ziekenhuis, Cardiology Department
RECRUITING

Deventer, 7416 SE, Netherlands
Frisius MC Leeuwarden, Hart- en Vaatcentrum
RECRUITING

Leeuwarden, 8934 AD, Netherlands
Gornoslaskie Centrum Medyczne im. prof. Leszka Gieca Slaskiego Uniwersytetu Medycznego w Katowicach
NOT_YET_RECRUITING

Katowice, 40-635, Poland
HagaZiekenhuis, Cardiology/Electrophysiology Unit
NOT_YET_RECRUITING

The Hague, 2545 AA, Netherlands
Health Center Uzice Cardiology Department
NOT_YET_RECRUITING

Užice, 33100, Serbia
Institute for Cardiovascular Disease "Dedinje" Department for Electrophysiology
NOT_YET_RECRUITING

Belgrade, Serbia
Institute for Cardiovascular Diseases Vojvodina Department of Interventional Electrophysiology
RECRUITING

Kamenitz, Serbia
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház-Rendelőintézet
RECRUITING

Szolnok, 5000, Hungary
MHAT National Cardiology Hospital EAD, Cardiology Department
WITHDRAWN

Sofia, SOF, 1365, Bulgaria
Maastricht University Medical Center, Cardiology Department
NOT_YET_RECRUITING

Maastricht, 6229 HX, Netherlands
Martini Hospital Groningen, Cardiology Department
RECRUITING

Groningen, 9728 NT, Netherlands
Małopolskie Centrum Sercowo-Naczyniowe PAKS Oddział Intensywnej Opieki Kardiologicznej
RECRUITING

Chrzanów, 85-231, Poland
Medical Center Nova Clinic
RECRUITING

Varna, VAR, 9020, Bulgaria
Máxima Medisch Centrum, Cardiology Department
RECRUITING

Veldhoven, 5504 DB, Netherlands
One Day Med Sp. z o.o. Clinical Trials Department
RECRUITING

Szczecin, 70-419, Poland
Policlinico Sant'Orsola Cardiology Department
RECRUITING

Bologna, BO, 40138, Italy
Polsko-Amerykańskie Kliniki Serca III Oddział Kardiologii Inwazyjnej, Angiologii i Elektrokardiologii
RECRUITING

Dąbrowa Górnicza, 41-300, Poland
Polsko-Amerykańskie Kliniki Serca X Oddział Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach im
RECRUITING

Tychy, 43-100, Poland
Rijnstate Ziekenhuis, Cardiology Department
RECRUITING

Arnhem, 6815 AD, Netherlands
Rivierenland Hospital, Cardiology Department
RECRUITING

Tiel, 4002 WP, Netherlands
SHATC Cardiolife, Invasive Cardiology
RECRUITING

Varna, VAR, 9000, Bulgaria
Sana Kliniken Oberfranken, Klinikum Coburg Kardiologie und Innere Medizin
RECRUITING

Coburg, 96450, Germany
Semmelweis Egyetem Városmajori Sziv- és Érsebészeti Klinika
RECRUITING

Budapest, 1122, Hungary
Soproni Gyógyközpont Soproni Erzsébet Oktató Kórház és Rehabilitációs Intézet
NOT_YET_RECRUITING

Sopron, 9400, Hungary
Spaarne Gasthuis, Cardiology Department
RECRUITING

Haarlem, 2035 RC, Netherlands
Szent-Györgyi Albert Klinikai Központ, Belgyógyászati Klinika
RECRUITING

Szeged, 6725, Hungary
UMHAT "Sveti Georgi" EAD, Department of Invasive Cardiology
RECRUITING

Plovdiv, PD, 4002, Bulgaria
Universitaets Klinikum Hamburg-Eppendorf (UKE Hamburg), Kardiologie
RECRUITING

Hamburg, 20246, Germany
University Clinical Center Kragujevac Clinic of Cardiology (Depar. Electrophysiology)
RECRUITING

Kragujevac, Serbia
University Clinical Center Nis Clinic for Cardiovascular Diseases Bulevar
RECRUITING

Niš, Serbia
University Clinical Centre of Serbia Department for Intensive Care in Arrhythmology
RECRUITING

Belgrade, Serbia
University Hospital Herlev and Gentofte Department of Cardiology
RECRUITING

Hellerup, 2730, Denmark
University of Modena and Reggio Emilia, Policlinico di Modena, Cardiology Department
RECRUITING

Modena, 30174, Italy
Universitätsklinikum Frankfurt Medizinische Klinik III - Kardiologie, Angiologie, Hämostaseologie, Nephrologie
RECRUITING

Frankfurt, 60590, Germany
Upper-Silesian Medical Center 2nd Department of Cardiology
NOT_YET_RECRUITING

Katowice, 40-635, Poland
Viborg Hospital, Department of Cardiology
RECRUITING

Viborg, 8800, Denmark

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