New pill aims to tame chaotic heartbeats in atrial fibrillation
NCT ID NCT07267949
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tests whether the experimental drug AP31969 can reduce the amount of time people with atrial fibrillation spend in an irregular heart rhythm. Two hundred adults with paroxysmal or persistent AF will receive either AP31969 or a placebo twice daily for several weeks. The main goal is to see if the drug lowers AF burden, measured by a heart monitor, and improves quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AP31969 (oral tablet)
What this could lead to
If successful, this could provide a new oral medication to better control atrial fibrillation and improve quality of life for patients.
What could go wrong
This is an early Phase 2 trial with only 200 participants, so results may not confirm effectiveness or safety. The drug may not reduce AF burden more than placebo.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ATRIAL FIBRILLATION (AF) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
ASST Grande Ospedale Metropolitano Niguarda Cardiology 3 - Electrophysiology "De Gasperis" Cardio Center
RECRUITINGMilan, 20162, Italy
-
Acibadem City Clinic, Cardiology Department
RECRUITINGSofia, SOF, 1000, Bulgaria
-
Aleksandrovska University Hospital, Clinic of Cardiology
RECRUITINGSofia, SOF, 1431, Bulgaria
-
Arcispedale Sant'Anna, Cardiology Department
RECRUITINGCona, FE, 444124, Italy
-
Belvárosi Egészségház, Platán Magánklinika
RECRUITINGZalaegerszeg, 8900, Hungary
-
Budai Irgalmasrendi Kórház
RECRUITINGBudapest, 1023, Hungary
-
Centrum Medyczne KERmed Cardiology Department
RECRUITINGBydgoszcz, 85-231, Poland
-
Dell'Angelo Hospital, Cardiology Department
RECRUITINGMestre, VE, 30174, Italy
-
Deventer Ziekenhuis, Cardiology Department
RECRUITINGDeventer, 7416 SE, Netherlands
-
Frisius MC Leeuwarden, Hart- en Vaatcentrum
RECRUITINGLeeuwarden, 8934 AD, Netherlands
-
Gornoslaskie Centrum Medyczne im. prof. Leszka Gieca Slaskiego Uniwersytetu Medycznego w Katowicach
NOT_YET_RECRUITINGKatowice, 40-635, Poland
-
HagaZiekenhuis, Cardiology/Electrophysiology Unit
NOT_YET_RECRUITINGThe Hague, 2545 AA, Netherlands
-
Health Center Uzice Cardiology Department
NOT_YET_RECRUITINGUžice, 33100, Serbia
-
Institute for Cardiovascular Disease "Dedinje" Department for Electrophysiology
NOT_YET_RECRUITINGBelgrade, Serbia
-
Institute for Cardiovascular Diseases Vojvodina Department of Interventional Electrophysiology
RECRUITINGKamenitz, Serbia
-
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház-Rendelőintézet
RECRUITINGSzolnok, 5000, Hungary
-
MHAT National Cardiology Hospital EAD, Cardiology Department
WITHDRAWNSofia, SOF, 1365, Bulgaria
-
Maastricht University Medical Center, Cardiology Department
NOT_YET_RECRUITINGMaastricht, 6229 HX, Netherlands
-
Martini Hospital Groningen, Cardiology Department
RECRUITINGGroningen, 9728 NT, Netherlands
-
Małopolskie Centrum Sercowo-Naczyniowe PAKS Oddział Intensywnej Opieki Kardiologicznej
RECRUITINGChrzanów, 85-231, Poland
-
Medical Center Nova Clinic
RECRUITINGVarna, VAR, 9020, Bulgaria
-
Máxima Medisch Centrum, Cardiology Department
RECRUITINGVeldhoven, 5504 DB, Netherlands
-
One Day Med Sp. z o.o. Clinical Trials Department
RECRUITINGSzczecin, 70-419, Poland
-
Policlinico Sant'Orsola Cardiology Department
RECRUITINGBologna, BO, 40138, Italy
-
Polsko-Amerykańskie Kliniki Serca III Oddział Kardiologii Inwazyjnej, Angiologii i Elektrokardiologii
RECRUITINGDąbrowa Górnicza, 41-300, Poland
-
Polsko-Amerykańskie Kliniki Serca X Oddział Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach im
RECRUITINGTychy, 43-100, Poland
-
Rijnstate Ziekenhuis, Cardiology Department
RECRUITINGArnhem, 6815 AD, Netherlands
-
Rivierenland Hospital, Cardiology Department
RECRUITINGTiel, 4002 WP, Netherlands
-
SHATC Cardiolife, Invasive Cardiology
RECRUITINGVarna, VAR, 9000, Bulgaria
-
Sana Kliniken Oberfranken, Klinikum Coburg Kardiologie und Innere Medizin
RECRUITINGCoburg, 96450, Germany
-
Semmelweis Egyetem Városmajori Sziv- és Érsebészeti Klinika
RECRUITINGBudapest, 1122, Hungary
-
Soproni Gyógyközpont Soproni Erzsébet Oktató Kórház és Rehabilitációs Intézet
NOT_YET_RECRUITINGSopron, 9400, Hungary
-
Spaarne Gasthuis, Cardiology Department
RECRUITINGHaarlem, 2035 RC, Netherlands
-
Szent-Györgyi Albert Klinikai Központ, Belgyógyászati Klinika
RECRUITINGSzeged, 6725, Hungary
-
UMHAT "Sveti Georgi" EAD, Department of Invasive Cardiology
RECRUITINGPlovdiv, PD, 4002, Bulgaria
-
Universitaets Klinikum Hamburg-Eppendorf (UKE Hamburg), Kardiologie
RECRUITINGHamburg, 20246, Germany
-
University Clinical Center Kragujevac Clinic of Cardiology (Depar. Electrophysiology)
RECRUITINGKragujevac, Serbia
-
University Clinical Center Nis Clinic for Cardiovascular Diseases Bulevar
RECRUITINGNiš, Serbia
-
University Clinical Centre of Serbia Department for Intensive Care in Arrhythmology
RECRUITINGBelgrade, Serbia
-
University Hospital Herlev and Gentofte Department of Cardiology
RECRUITINGHellerup, 2730, Denmark
-
University of Modena and Reggio Emilia, Policlinico di Modena, Cardiology Department
RECRUITINGModena, 30174, Italy
-
Universitätsklinikum Frankfurt Medizinische Klinik III - Kardiologie, Angiologie, Hämostaseologie, Nephrologie
RECRUITINGFrankfurt, 60590, Germany
-
Upper-Silesian Medical Center 2nd Department of Cardiology
NOT_YET_RECRUITINGKatowice, 40-635, Poland
-
Viborg Hospital, Department of Cardiology
RECRUITINGViborg, 8800, Denmark