ATRIAL FIBRILLATION (AF)

This study looks at whether pulsed-field ablation (PFA), a non-thermal technique that uses electric pulses to target faulty heart tissue, can reverse structural changes in the heart caused by persistent atrial fibrillation (AF). Researchers will enroll 30 people with persistent A…

This study tests a 'nudge' program—including text reminders, a medication calendar, and an action plan—to help 84 adults with atrial fibrillation take their blood thinners consistently. Participants will watch an educational video, create a daily pill-taking routine, and receive …

This study tests a new technique called PWI-Box, which uses a device named GeminiS to isolate the pulmonary veins and treat atrial fibrillation (AF) during open-heart surgery. About 200 adults with AF who are already scheduled for heart surgery via sternotomy will take part. The …

This trial tests whether adding extra ablation lines to the standard pulsed-field ablation procedure helps people with long-standing atrial fibrillation (AF) stay in normal heart rhythm. 430 participants with AF lasting 1-3 years will be randomly assigned to receive either standa…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a bloo…

This study compares two types of pacemaker procedures in adults with heart failure and atrial fibrillation who are not candidates for rhythm control. All participants will receive a heart ablation, then be randomly assigned to either conduction system pacing or standard cardiac r…

This study tests whether a new catheter ablation system using pulsed field energy can better control persistent atrial fibrillation (AF) by targeting low-voltage areas in the heart and isolating the superior vena cava, in addition to standard pulmonary vein isolation. About 618 a…

This study tests a new way to treat atrial fibrillation (AFib) using short electrical pulses instead of heat. The goal is to block abnormal heart signals in a specific area called the mitral isthmus. Thirty adults with AFib will receive this treatment during a standard procedure …

This clinical trial tests whether giving two electrical shocks at once (dual shock) is better than the standard single shock for restoring normal heart rhythm in people with persistent atrial fibrillation. About 177 participants will be randomly assigned to receive either a stand…

This study tests whether taking a daily probiotic capsule for 12 weeks can reduce the chance of atrial fibrillation (AF) returning in people who have just had a cardioversion (a procedure to restore normal heart rhythm). Fifty-six adults aged 40 and older with persistent AF will …

This study compares a newer pacing method called Left Bundle Branch Area Pacing (LBBAP) with the standard coronary sinus pacing for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if LBBAP better imp…

This study tests whether a special pacing method called Bachmann bundle pacing can prevent new atrial fibrillation (a type of irregular heartbeat) in people with heart failure who already need a pacemaker or defibrillator. About 110 participants will be randomly assigned to recei…

This study tests whether staying alcohol-free for six months after a heart ablation procedure can reduce the return of atrial fibrillation (AF), a common heart rhythm problem. Researchers will enroll 414 adults who drink at least three alcoholic beverages per week and are schedul…

This trial will enroll about 3,200 people with paroxysmal atrial fibrillation (AF) to see if using a smartwatch to continuously track AF burden can guide earlier and better treatment. Participants will be monitored with a wearable device, and if their AF burden is high, doctors w…

This study tests whether adding acupuncture to standard care can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who have already had a catheter ablation. About 120 adults aged 20 to 75 will be randomly assigned to receive either acupunctur…

This study looks at whether people with atrial fibrillation who have had a successful heart ablation and also have a heart stent can safely stop taking blood thinners. Participants who maintain a normal heart rhythm for at least a year after ablation will either continue blood th…

This study compares two common heart rate-lowering drugs, verapamil and metoprolol, in 436 adults with paroxysmal atrial fibrillation (AF). It also tests whether using a smartwatch for self-care can reduce hospital visits and improve symptoms. The goal is to find better ways to m…

This study will test whether adding fexuprazan, a stomach acid reducer, to standard blood thinners can prevent upper gastrointestinal bleeding in people with atrial fibrillation. About 1,000 high-risk participants will be randomly assigned to receive either the combination therap…

This study will test a combined procedure in 150 people with atrial fibrillation (AFib) who are at risk for stroke. Doctors will use pulse field ablation to correct the heart's rhythm and then close off a small pouch in the heart (the left atrial appendage) to prevent blood clots…

This early study tests a new, wire-free pacemaker (ALPS) in 10 people with bradycardia (slow heart rate). The goal is to see if it is safe and works well. Participants will be monitored for device-related problems and how well the pacemaker controls their heart rhythm.

This study compares two blood thinners, apixaban and warfarin, in 120 adults with atrial fibrillation who recently had heart valve repair or replacement. The goal is to see if apixaban causes fewer major bleeding events while still preventing blood clots. Participants will be fol…

This study compares two ablation procedures for people with persistent atrial fibrillation (AF), a heart rhythm problem. Half of the 450 participants will get standard treatment (isolating the pulmonary veins), while the other half will get extra ablation lines in the heart. The …

This study looks at two ways to treat atrial fibrillation (a common heart rhythm problem) in people aged 78 and older. One approach uses a procedure called catheter ablation to fix the heart's electrical signals, while the other uses medications to control heart rate or rhythm. R…

This study compares the safety of the drug flecainide against standard treatments (sotalol or amiodarone) in about 988 adults with atrial fibrillation and stable coronary artery disease. Participants will be randomly assigned to one treatment and followed for at least a year to t…

This study tests whether taking semaglutide (a drug used for diabetes and weight loss) before a standard heart procedure called catheter ablation can help prevent atrial fibrillation from coming back. The trial will include 240 adults with obesity and symptomatic atrial fibrillat…

This study looks at people with atrial fibrillation (an irregular heartbeat) who have already had a successful mitral valve repair. It compares two approaches: catheter ablation (a procedure to fix the heart's electrical signals) versus standard medical care. The goal is to see i…

This early-stage trial tests whether relaxin, a natural hormone given as a daily injection, can reduce the burden of atrial fibrillation (AF) in 208 veterans who have not responded to standard medications and are scheduled for catheter ablation. The study aims to see if relaxin c…

This trial tests whether dapagliflozin, a drug typically used for diabetes, can reduce the return of atrial fibrillation after a heart ablation procedure. The study focuses on patients with persistent AF and increased epicardial adipose tissue (heart fat), which is linked to high…

This study compares two types of medicine for atrial fibrillation (AF), a condition causing irregular heartbeat. About 1,900 adults diagnosed with AF in the past year will be randomly assigned to take either dronedarone or a standard Class Ic drug (like flecainide). Researchers w…

This study tests whether taking semaglutide (Wegovy) for at least three months before a first-time atrial fibrillation ablation can improve heart rhythm outcomes. 200 overweight or obese adults scheduled for ablation will be randomly assigned to either standard care or semaglutid…

This study compares two procedures for treating atrial fibrillation (AF) in people with heart failure: catheter ablation to restore normal heart rhythm, or a pacemaker plus ablation to control heart rate. About 1056 adults with both conditions will be followed for several years t…

This study looks at two ways to treat atrial fibrillation (AF) that comes back after a first ablation. Patients who still have symptoms despite medication will be randomly assigned to either a repeat ablation or a pacemaker with AV node ablation. The goal is to see which approach…

This study explores whether an additional CT scan of the heart, taken right after a standard scan for lung clots, can effectively detect blood clots in the left atrial appendage (LAA) in people with atrial fibrillation. Currently, detecting these clots requires a more involved pr…

This study tests a new way to find a hidden heart condition called cardiac amyloidosis in people with atrial fibrillation (AF). Researchers will use AI to analyze EKGs and CT scans to spot early signs of the disease. About 500 adults with AF and certain warning signs will be spli…

This study tests if a smartphone app and a special bed mat can detect a type of fast heartbeat (supraventricular tachycardia) in children aged 0-10. Researchers will compare these methods to the standard hospital heart monitor. If successful, it could make diagnosis easier and le…

This study will test new ultrasound techniques, combined with artificial intelligence, to more accurately measure heart filling pressure in patients who have both heart failure and atrial fibrillation. Current methods are unreliable for these patients, making diagnosis and treatm…

This study will test whether an artificial intelligence (AI) program can accurately detect atrial fibrillation (AF) using data from consumer smartwatches. Researchers will enroll 40 adults with AF who will wear a smartwatch while their heart rhythm is also monitored with standard…

This study tests a new technology that listens to your voice during short phone calls to detect atrial fibrillation, a common heart rhythm problem. Researchers will enroll 40 adults scheduled for a heart reset procedure (cardioversion) and compare voice recordings with standard h…

This study will test two different surgical techniques used during heart bypass surgery to see which one better prevents a common complication called atrial fibrillation (irregular heartbeat). The trial will involve 122 adults having their first planned bypass surgery. Researcher…

This study compares deep sedation using a combination of three drugs (dexmedetomidine, remimazolam, and remifentanil) to standard general anaesthesia for patients undergoing a procedure to treat atrial fibrillation (an irregular heartbeat). The goal is to see if deep sedation can…

This study tests whether starting with a higher shock energy (360 J) is better than a standard 200 J for restoring normal heart rhythm in people with atrial fibrillation. About 400 adults will be randomly assigned to one of three groups, including a personalized approach based on…

This study compares two ways to sedate patients during a heart scan and electric shock treatment for atrial fibrillation. Currently, a cardiologist gives mild sedation for the scan, but an anaesthesiologist must give stronger sedation for the shock, causing delays. Researchers wa…

This study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. Instead of starting with aerobic exercise like walking, participants will first do 2 months of progressive re…

This study tests a simple mental exercise called episodic future thinking to help people with atrial fibrillation stick to their blood thinner medication. 68 participants will be split into two groups: one gets the future-thinking prompts plus usual care, the other gets usual car…

This study will enroll 100 people who have already had a heart procedure (pulsed field ablation) for atrial fibrillation. Participants will wear a BodyGuardian monitor for a period after the procedure to see if it catches any return of irregular heartbeats. The study also asks pa…

This study looks at 150 people with persistent atrial fibrillation (a type of irregular heartbeat) who are scheduled for a heart procedure called ablation. Researchers want to see if levels of a protein called BDNF in the blood are linked to signs of heart muscle damage (atrial c…

This study will test a new ultrasound catheter called VeriSight Pro that takes pictures from inside the heart. Doctors will use it during procedures like closing a hole in the heart or fixing a valve. The goal is to see if it helps guide these procedures safely and effectively. A…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study will look at 40 people with both hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) to understand why AF is more common and harder to treat in HCM. Researchers will measure electrical signals in the heart and use advanced imaging. The goal is to find clues …

This study will check how well heart failure and atrial fibrillation patients take their medicines after being admitted to the coronary care unit. Researchers will interview 250 adults to understand their medication beliefs and whether their prescriptions are appropriate. The goa…

This observational study will follow 10,000 people with atrial fibrillation for 24 months. Researchers will use smartwatch data to measure how much time the heart is in AF (AF burden) and see if that predicts strokes or blood clots. The goal is to find a clear threshold where blo…

This study tests whether an artificial intelligence (AI) analysis of a simple electrocardiogram (ECG) can safely replace routine heart ultrasound (echocardiography) in managing atrial fibrillation (AF). About 1,724 adults with AF will be randomly assigned to either AI-ECG guided …

This study will test a new software system that measures tiny electrical signals in the heart after a procedure called pulsed field ablation, used to treat atrial fibrillation (an irregular heartbeat). Researchers will enroll 30 adults with AF who are already scheduled for ablati…

This study will follow 300 people having planned coronary bypass surgery to see if the amount of belly fat they carry affects their risk of developing atrial fibrillation (a type of irregular heartbeat) after the operation. Before surgery, doctors will use ultrasound to measure t…

This study will test whether an artificial intelligence (AI) tool can better predict stroke risk in 1,000 people aged 65-95 with atrial fibrillation, compared to current methods. The AI analyzes health records and heart data to identify high-risk individuals early. The goal is to…

This registry will follow 3,500 adults with atrial fibrillation who have a low risk of stroke. Researchers will track complications like stroke and hospitalizations over time to see how patients are managed in everyday medical practice. The goal is to better understand outcomes a…

This study looks at whether a newer, gentler heart procedure called pulse-field ablation (PFA) can reverse harmful changes in the heart's upper chambers caused by atrial fibrillation. Researchers will compare CT scans taken before and 3 months after the procedure in 200 adults. T…

This study follows 700 cancer patients who take blood thinners and are scheduled for surgery or medical procedures. Researchers will track how often major bleeding or clotting events occur within 30 days after the procedure. The goal is to see if current blood thinner management …

This study will implant a small heart monitor under the skin of 100 people with moderate-to-severe mitral valve regurgitation who have few or no symptoms. The device will track heart rhythms for up to three years to find hidden atrial fibrillation that standard tests might miss. …

This study will collect blood, urine, stool, voice recordings, and other data from 3000 adults having planned heart surgery. Researchers will analyze this information to find markers that could predict complications like delirium, bleeding, kidney injury, and irregular heartbeat.…

This study uses CT scans to compare heart fat and chamber size in people with and without atrial fibrillation (AF). Researchers will enroll 600 adults to see if fat distribution differs between those with normal rhythm, occasional AF, and persistent AF. No drugs or treatments are…

This study will follow about 3,500 adults in China who have atrial fibrillation (an irregular heartbeat) along with metabolic disorders like obesity, diabetes, or high cholesterol. Researchers want to learn how these combined conditions affect risks for stroke, heart failure, and…

This study looks at 460 adults who need a pacemaker but have never had atrial fibrillation. Researchers will compare three pacing approaches to see which one best reduces brief, device-detected atrial high-rate episodes over two years. The goal is to find out if pacing the heart'…

This study tests whether a WhatsApp-based chatbot can help people recovering from atrial fibrillation ablation. About 76 adults will either use the chatbot to report symptoms and well-being for 3 months or receive standard hospital follow-up. The goal is to see if the chatbot is …

This study looks at 40 adults with atrial fibrillation and heart failure to see if lowering their resting heart rate from 100-110 bpm to a more normal level improves exercise ability and quality of life. Participants will do treadmill tests before and after either a cardioversion…

This study looks at 700 people having their first heart ablation for atrial fibrillation to see if men and women have different heart structures and outcomes. Researchers will compare anatomy, procedure details, and how well the treatment works after 12 months. The goal is to und…