ATRIAL FIBRILLATION (AF)

This study tests whether taking probiotics can lower the chance of atrial fibrillation (AF) returning after a procedure called cardioversion, which resets the heart's rhythm. About 56 adults aged 40 and older with persistent AF will take probiotics or a placebo for a period after…

This study tests whether burning extra lines in the heart, on top of the standard procedure, helps people with persistent atrial fibrillation stay free from abnormal heart rhythms for longer. About 450 adults with persistent AF (but not long-standing) will be randomly assigned to…

This study tests two common heart rate-lowering drugs, verapamil and metoprolol, in 436 adults with paroxysmal atrial fibrillation (AF), a condition causing irregular heartbeats. Some participants will also use a smartwatch to guide their own care. The goal is to see which approa…

This study tests doing two heart procedures at the same time in people with atrial fibrillation (an irregular heartbeat). The first uses energy pulses to fix the heart's electrical signals. The second closes a small pouch in the heart to lower stroke risk and reduce the need for …

This study tests whether taking semaglutide (a weight-loss drug) before a standard heart procedure called catheter ablation helps people with obesity and atrial fibrillation stay free from abnormal heart rhythms for a year. About 240 adults with a BMI of 30 or higher (or 28 with …

This study looks at two common treatments for atrial fibrillation (an irregular heartbeat) in people aged 78 and older. One treatment is a procedure called catheter ablation, which targets the heart's faulty electrical signals. The other is medication to control heart rate or rhy…

This study compares two procedures—catheter ablation and pacemaker therapy—for people with both atrial fibrillation (irregular heartbeat) and heart failure. About 1,056 adults will be randomly assigned to one of the two treatments. The goal is to see which approach better reduces…

This study looks at two ways to treat atrial fibrillation (AF) that comes back after a first ablation procedure. Sixteen people who still have symptoms despite medication will be randomly assigned to either a repeat ablation or a pacemaker with a special type of pacing plus a pro…

This study looks at people with atrial fibrillation (an irregular heartbeat) who have already had a procedure to fix a leaky mitral valve. It compares two approaches: doing a catheter ablation (a procedure to fix the heartbeat) versus standard medical care. The goal is to see if …

This study looks at whether people with atrial fibrillation (AF) and prior heart stents can safely stop taking blood thinners if their heart rhythm stays normal for at least a year after AF ablation. Participants will either continue blood thinners or switch to a single antiplate…

This study tests a newer, gentler way to treat atrial fibrillation (AFib) using short electrical pulses instead of heat. The goal is to block abnormal heart signals in a tricky area called the mitral isthmus. Thirty adults with AFib will receive this treatment during a standard p…

This study compares the safety of the drug flecainide to standard rhythm-control medications (sotalol or amiodarone) in 988 adults with atrial fibrillation and stable coronary artery disease. Participants are randomly assigned to one treatment and followed for at least a year to …

This study looks at doing two heart procedures at the same time for people with atrial fibrillation (an irregular heartbeat). The first uses pulsed field ablation to fix the heart's electrical problem, and the second closes off a small pouch in the heart to lower stroke risk. Abo…

This study compares a newer pacing method (left bundle branch area pacing) with the standard approach for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if the newer method improves the heart's pump…

This study tests a new method to treat atrial fibrillation (a common heart rhythm problem) during open-heart surgery. About 200 adults having heart surgery will receive a special procedure that isolates the pulmonary veins using a device called GeminiS. The goal is to see if this…

This study tests whether simple nudges—like text message reminders, a medication calendar, and a personal plan—can help people with atrial fibrillation stick to their blood-thinning medication. Researchers will compare 84 participants who get these nudges to those who receive usu…

This study compares two blood thinners, apixaban and warfarin, in 120 adults with atrial fibrillation who recently had heart valve repair or replacement. The goal is to see if apixaban causes less major bleeding while still preventing blood clots. Participants will be followed fo…

This study looks at whether a new type of stomach acid reducer, fexuprazan, can prevent serious upper stomach bleeding in people with atrial fibrillation who take blood thinners. About 1,000 high-risk participants will either get fexuprazan plus their blood thinner or just the bl…

This study looks at whether using a CPAP machine for 12 months after a heart procedure (catheter ablation) can prevent atrial fibrillation from coming back in people who also have obstructive sleep apnea. About 658 adults aged 18-75 with both conditions will be randomly assigned …

This study looks at whether adding acupuncture to standard care can reduce the chance of atrial fibrillation returning after a heart procedure called catheter ablation. About 120 adults with persistent atrial fibrillation will be split into two groups: one gets acupuncture plus u…

This study tests whether using a smartwatch to continuously track atrial fibrillation (AF) patterns can help doctors decide the best time to start or change treatment. About 3,194 adults with paroxysmal AF will wear a smartwatch to measure their AF burden. If the burden is high, …

This early study tests a new leadless pacemaker (ALPS) for people with a slow heartbeat (bradycardia). The device is placed directly in the heart without wires. The study will check if it is safe and works well in 10 adults who need a single-chamber pacemaker.

This study tests whether adding Relaxin, a natural hormone, to standard care can lower the amount of atrial fibrillation (AF) in 208 Veterans who still have symptoms despite medication and are scheduled for a heart ablation procedure. The goal is to see if Relaxin reduces oxidati…

This study tests a simple mental exercise called Episodic Future Thinking (EFT) to help people with atrial fibrillation remember to take their blood thinner medication. 68 participants will either get the EFT training plus usual care, or just usual care. Researchers will check if…

This study tests whether a special pacing method called Bachmann bundle pacing can prevent new atrial fibrillation (an irregular heartbeat) in people with heart failure who need a pacemaker or defibrillator. About 110 participants will be randomly assigned to receive either the n…

This study tests whether taking semaglutide (Wegovy) before a standard heart procedure for atrial fibrillation (AF) can help prevent the abnormal heart rhythm from coming back. About 200 overweight or obese adults scheduled for their first AF ablation will either receive semaglut…

This study compares two treatments for elderly frail patients with atrial fibrillation (AFib) who are at high risk for both stroke and bleeding. One group gets a heart procedure (catheter ablation) plus a device to close off a part of the heart (left atrial appendage occlusion), …

This study looks at whether staying away from alcohol for six months after a common heart procedure (ablation) can lower the chance of atrial fibrillation (AF) coming back. About 414 adults who drink moderately or more will be split into two groups: one that stops drinking and on…

This study compares two types of medicine for atrial fibrillation (AF), a condition causing irregular heartbeats. About 1,900 adults diagnosed with AF in the past year will be randomly assigned to take either dronedarone or a standard Class Ic drug (like flecainide). Researchers …

This study tests whether dapagliflozin, a drug typically used for diabetes, can help prevent atrial fibrillation from coming back after a heart ablation procedure. The trial focuses on people with persistent AFib who have increased epicardial adipose tissue (fat around the heart)…

This study compares a new method called pulsed field ablation (PFA) using the VOLT catheter to standard heat or cold ablation for treating atrial fibrillation (AF). About 136 adults with AF will be randomly assigned to receive either PFA or standard ablation. The goal is to see i…

This study tests whether a non-invasive screening method using AI-ECG and CT scans can detect cardiac amyloidosis early in 500 adults with atrial fibrillation who have warning signs. Participants are split into two groups: one gets the extra screening plus usual AF care, the othe…

This study compares an AI-enhanced electrocardiogram (ECG) to the standard heart ultrasound (echocardiogram) for managing atrial fibrillation. About 1,700 adults with AF and a moderate-to-high stroke risk will be randomly assigned to either AI-ECG-guided care or usual care with e…

This study tests whether analyzing a person's voice during short phone calls can detect atrial fibrillation, a common heart rhythm disorder. Forty adults scheduled for a cardioversion procedure will provide voice recordings before, right after, and at a follow-up visit. The resul…

This study tests if smartphone sensors and bed sensors can reliably detect supraventricular tachycardia (SVT) in children aged 0-10. Researchers will compare these methods to standard hospital ECG monitoring. The goal is to develop a simple, non-invasive way to diagnose SVT in yo…

This study tests two techniques—a pericardial window and a retro-cardiac drain—to prevent atrial fibrillation and other heart sac complications after coronary artery bypass surgery. About 122 adults with good heart function will be randomly assigned to one method. The goal is to …

This large, late-stage study is testing two new injectable drugs, REGN7508 and REGN9933, to prevent strokes and blood clots in people with an irregular heartbeat called atrial fibrillation. The study is specifically for people who cannot or choose not to take standard oral blood …

This study tests whether a cardiologist can safely give a mild sedative (midazolam) for a heart ultrasound and electric shock treatment, instead of needing a separate anesthesiologist. The goal is to reduce delays and shorten hospital stays for people with atrial fibrillation or …

This study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. The program starts with resistance training to build muscle strength, then adds aerobic exercise to improve s…

This study tests whether a WhatsApp-based chatbot is a practical and helpful way for people to report symptoms and health updates after atrial fibrillation ablation. About 76 adults who had the procedure will either use the chatbot or get standard follow-up care for 3 months. The…

This study tests whether artificial intelligence (AI) combined with data from consumer wearable devices (like smartwatches) can accurately detect and predict atrial fibrillation (AF), a common heart rhythm problem. Researchers will enroll 40 adults with AF to develop and evaluate…

This study uses CT scans to compare fat around the heart in people with and without atrial fibrillation (AF). Researchers will look at 600 adults to see if fat distribution differs between those with normal rhythm, occasional AF, and persistent AF. The goal is to better understan…

This study looks at how well people with both atrial fibrillation (an irregular heartbeat) and heart failure can exercise before and after a procedure to control their heart rate. About 40 adults will do treadmill tests and have blood drawn to measure heart efficiency. The goal i…

This study aims to improve how doctors measure heart pressure in patients who have both heart failure and atrial fibrillation. Current ultrasound methods are unreliable for these patients, making it hard to diagnose and treat them properly. Researchers will test new ultrasound te…

This study will follow 10,000 people with atrial fibrillation (AF) for two years to see if the total time they spend in AF (called AF burden) is linked to strokes and blood clots. Participants will use their own smartphones and smartwatches to track their heart rhythm. The goal i…

This study is testing a new software system that measures tiny electrical signals in the heart after a procedure called pulsed field ablation (PFA) for atrial fibrillation (AF). About 30 adults with AF will have their heart signals recorded during their first PFA treatment. The g…

This study will check if the amount of deep belly fat (visceral fat) measured before heart bypass surgery is linked to a higher chance of developing atrial fibrillation (an irregular heartbeat) after the operation. Researchers will use ultrasound to measure belly fat in 300 adult…

This study observes 30 adults in Mexico who are already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans, heart CT scans, and body composition tests to see how the drug affects knee cartilage, heart fat, and overall body health over one y…

This study looks at why atrial fibrillation (AFib) happens more often and is harder to treat in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle is thicker than normal. Researchers will study electrical signals in the heart and use advanced imagin…

This study looks at how men and women differ in heart structure and treatment results after a first procedure for atrial fibrillation (an irregular heartbeat). Researchers will compare anatomy, procedure details, and success rates in 700 patients. The goal is to understand if per…

This study compares two catheters used during a procedure to treat atrial fibrillation (an irregular heartbeat). The goal is to see if a newer catheter can confirm treatment success faster than the standard method. About 30 adults with persistent AF or atrial flutter will take pa…

This study looks at whether a newer, gentler heart procedure called pulse-field ablation (PFA) can reverse harmful changes in the heart's upper chambers in people with atrial fibrillation (an irregular heartbeat). Researchers will compare CT scans taken before and 3 months after …

This study looks at how safe current blood thinner management is for 700 cancer patients who need surgery or medical procedures. Researchers will track how often serious bleeding or blood clots happen within 30 days after the procedure. The goal is to use this information to impr…

This study will watch 1,000 adults who are already having a heart procedure. Doctors will use a special ultrasound catheter (VeriSight Pro) to take pictures inside the heart. The goal is to see if this tool is safe and helps guide the procedure correctly. No new treatment is bein…

This study looks at 3,000 adults having planned heart surgery to find out if things like genes, blood markers, and even voice recordings can help predict serious complications such as kidney injury, delirium, or bleeding. Researchers will collect samples and data before, during, …

This study aims to develop and test an artificial intelligence (AI) model to better predict the risk of stroke, heart attack, and other serious heart-related events in people with atrial fibrillation (an irregular heartbeat). Researchers will use electronic health records from 1,…

This study will use a small device implanted under the skin to continuously monitor the heart rhythm of 100 people with moderate-to-severe mitral valve regurgitation (a leaky heart valve) who have few or no symptoms. The goal is to find out how often hidden atrial fibrillation (a…

This study will check how well heart failure and atrial fibrillation patients take their prescribed medications after being admitted to the coronary care unit. Researchers will use questionnaires to understand patients' beliefs about their medicines and whether their prescription…

This study is a registry that will follow about 3,500 adults with atrial fibrillation (a heart rhythm condition) to see how they are treated in everyday medical practice and what health outcomes they experience. It focuses on people with a low risk of stroke. The goal is to gathe…

This study looks at 460 adults who need a pacemaker but have never had atrial fibrillation. Researchers will compare three pacing methods to see which one best prevents short bursts of abnormal heart rhythms. Participants will be monitored for up to two years using their pacemake…

This study aims to better understand how common health conditions like obesity and diabetes affect people with atrial fibrillation (AF), an irregular heart rhythm. Researchers will track over 3,400 patients in China for several years to see how their health changes over time. The…