New combo ablation aims to tame stubborn AFib

NCT ID NCT07633509

Not yet recruiting Disease control Sponsor: Yunlong Wang Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This trial tests whether adding extra ablation lines to the standard pulsed-field ablation procedure helps people with long-standing atrial fibrillation (AF) stay in normal heart rhythm. 430 participants with AF lasting 1-3 years will be randomly assigned to receive either standard PFA or PFA plus additional radiofrequency and ethanol ablation. The main goal is to see if the more extensive procedure reduces AF recurrence at 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pulsed-field ablation and radiofrequency ablation catheters, plus ethanol infusion into the vein of Marshall
What this could lead to: If it works, this could lead to a more effective procedure that helps more people with long-standing atrial fibrillation stay in normal heart rhythm for longer.
What could go wrong: This is an early-stage trial with no results yet. The extra ablation may not improve outcomes and could increase procedure time or complication risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION (AF) ATRIAL FIBRILLATION CATHETER ABLATION

Contacts and locations

Locations

Beijing Anzhen Hospital, Capital Medical University

Beijing, Beijing Municipality, 101118, China
Fuwai Hospital

Beijing, Beijing Municipality, 100039, China
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University , Jiangsu Women and Children Health Hospital）

Nanjing, Jiangsu, 210029, China

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